AiPD: Autoinhibited Protein Database

Gene name	Arhgap26 (Kiaa0621)
Protein name	Rho GTPase-activating protein 26
Names	Rho-type GTPase-activating protein 26
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:71302
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

549-642 (Predicted disordered autoinhibitory region) PR

549-642 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6ZQ82-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389447934	55	S>L	No	EVA
rs3389512165	68	K>N	No	EVA
rs3389501567	69	F>L	No	EVA
rs3389503827	76	E>*	No	EVA
rs3389466271	128	R>M	No	EVA
rs3389499211	143	G>A	No	EVA
rs3389492501	152	S>F	No	EVA
rs3389410478	157	E>V	No	EVA
rs3389501555	172	Q>*	No	EVA
rs3389499266	198	E>K	No	EVA
rs3389410550	250	M>V	No	EVA
rs3389494576	267	T>I	No	EVA
rs3389496049	287	H>Y	No	EVA
rs3389500308	288	Y>C	No	EVA
rs3389466300	311	G>E	No	EVA
rs3389494591	346	V>L	No	EVA
rs3389410523	375	R>G	No	EVA
rs3408357828	408	Q>R	No	EVA
rs3389457539	439	D>V	No	EVA
rs3389501571	486	V>L	No	EVA
rs3389499237	525	V>L	No	EVA
rs3389457487	547	I>F	No	EVA
rs3389479134	551	K>N	No	EVA
rs3389503754	554	N>S	No	EVA
rs3389466274	567	I>T	No	EVA
rs29932603	598	K>E	No	EVA
rs3389479097	607	V>M	No	EVA
rs3406562303	616	R>T	No	EVA
rs224576102	640	S>N	No	EVA
rs3389499249	642	Q>H	No	EVA
rs3389514597	648	S>C	No	EVA
rs3389479118	673	L>F	No	EVA
rs3407400281	692	T>P	No	EVA
rs3389512227	742	L>P	No	EVA
rs3389457572	751	R>S	No	EVA
rs3408358905	758	F>L	No	EVA
rs3408500790	761	A>S	No	EVA
rs3389492548	767	C>Y	No	EVA
rs3389512198	789	S>A	No	EVA
rs3389494562	797	G>A	No	EVA
rs3389500323	810	Y>F	No	EVA

Type	Name	Position	InterPro Accession
domain	Rho GTPase-activating protein domain	383 - 568	IPR000198
domain	SH3 domain	756 - 814	IPR001452
domain	Pleckstrin homology domain	265 - 371	IPR001849
domain	BAR domain	6 - 249	IPR004148
domain	GRAF, SH3 domain	759 - 814	IPR035481
domain	GRAF, BAR domain	19 - 225	IPR035483
domain	GRAF, PH domain	267 - 371	IPR047225

		Description
EC Number
Subcellular Localization	Cell junction, focal adhesion Cytoplasm, cytoskeleton Endosome membrane	Colocalizes with actin stress fibers and cortical actin structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
phospholipid binding	Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZMW5	ARHGAP26	Rho GTPase-activating protein 26	Gallus gallus (Chicken)	PR
Q7YQL6	OPHN1	Oligophrenin-1	Pan troglodytes (Chimpanzee)	PR
O60890	OPHN1	Oligophrenin-1	Homo sapiens (Human)	PR
A6NI28	ARHGAP42	Rho GTPase-activating protein 42	Homo sapiens (Human)	PR
Q9UNA1	ARHGAP26	Rho GTPase-activating protein 26	Homo sapiens (Human)	PR
B2RQE8	Arhgap42	Rho GTPase-activating protein 42	Mus musculus (Mouse)	PR
Q99J31	Ophn1	Oligophrenin-1	Mus musculus (Mouse)	PR
P0CAX5	Ophn1	Oligophrenin-1	Rattus norvegicus (Rat)	PR
B5DFQ4	arhgap26	Rho GTPase-activating protein 26	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR