B5DFQ4

PR
Gene name
arhgap26
Protein name
Rho GTPase-activating protein 26
Names
Rho-type GTPase-activating protein 26
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100145296
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

561-712 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B5DFQ4

Entry ID Method Resolution Chain Position Source
AF-B5DFQ4-F1 Predicted AlphaFoldDB

No variants for B5DFQ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B5DFQ4

No associated diseases with B5DFQ4

7 regional properties for B5DFQ4

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 383 - 568 IPR000198
domain SH3 domain 701 - 759 IPR001452
domain Pleckstrin homology domain 265 - 371 IPR001849
domain BAR domain 6 - 249 IPR004148
domain GRAF, SH3 domain 704 - 759 IPR035481
domain GRAF, BAR domain 19 - 225 IPR035483
domain GRAF, PH domain 267 - 371 IPR047225

Functions

Description
EC Number
Subcellular Localization
  • Cell junction, focal adhesion
  • Cytoplasm, cytoskeleton
  • Endosome membrane
  • Colocalizes with actin stress fibers and cortical actin structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

3 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of small GTPase mediated signal transduction Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZMW5 ARHGAP26 Rho GTPase-activating protein 26 Gallus gallus (Chicken) PR
Q7YQL6 OPHN1 Oligophrenin-1 Pan troglodytes (Chimpanzee) PR
A6NI28 ARHGAP42 Rho GTPase-activating protein 42 Homo sapiens (Human) PR
O60890 OPHN1 Oligophrenin-1 Homo sapiens (Human) PR
Q9UNA1 ARHGAP26 Rho GTPase-activating protein 26 Homo sapiens (Human) PR
Q99J31 Ophn1 Oligophrenin-1 Mus musculus (Mouse) PR
B2RQE8 Arhgap42 Rho GTPase-activating protein 42 Mus musculus (Mouse) PR
Q6ZQ82 Arhgap26 Rho GTPase-activating protein 26 Mus musculus (Mouse) PR
P0CAX5 Ophn1 Oligophrenin-1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGLPPLEFSD CYLDSPQFRE RLKSHEIELD KTNKFIKELI KDGKSLVAAH KNLSCAKRKF
70 80 90 100 110 120
AGSLNEFKFR CIGDAETDDE ICIARSLQEF AAVLGNLEDE RIRMIDNSGE VLISPLEKFR
130 140 150 160 170 180
KEQVGAAKEV KKKYDKESEK YCAMLEKHMN LSSKKKEVLL HEADVQLDQM RQHFYEVSLE
190 200 210 220 230 240
YVLKVHEVQE RKMFEFVEPL LAFLQGLFTF YHHGYELAKD FSDFKTQLSI SIQNTRDRFE
250 260 270 280 290 300
GTRSEVESLM KKMKENPHEH LALSPYTMEG YLYVQEKRHF GTSWVKHYCT YQRETKQMTM
310 320 330 340 350 360
VPFDQKSGGK VGEEEIIHLK SCIRRKTESI EKRFCFDVEG VDRPTVLTMQ ALSEEDRKLW
370 380 390 400 410 420
MEAMDGREPV YNSNKDSQSE GTAQLDNIGF SIIRKCIQAV ETRGINEQGL YRIVGVNSRV
430 440 450 460 470 480
QKLLNFLMDP KISPETETEI PSEWEIKTIT SSLKTYLRML PGPLMTYQFQ RSFIKAAKLE
490 500 510 520 530 540
NQESRIKEIH CLIHRLPEKN RQMLNLLMTH LANVAAHHKQ NLMTVANLGI VFGPTLLRPQ
550 560 570 580 590 600
EETVAAIMDI KFQNIVVEII IENYEKMFST VPEMPQTNSQ LHLSRKRSSD SKPPSCSERP
610 620 630 640 650 660
LTLFHTTHNT EKEEKRNSVN SSAESVSSSN ANSSANSTCT QCSNMNNLNA SDPDLDVAKA
670 680 690 700 710 720
SRPNSLSLNP SPTSPPTCPM FSAPSSPMPT SSTSSDSSPV SVPRKAKALY ACKAEHDSEL
730 740 750
SFSAGTVFDN VYPSQEPGWL EGILNGKTGL IPENYVEFL