AiPD: Autoinhibited Protein Database

Gene name	Arhgap42
Protein name	Rho GTPase-activating protein 42
Names	Rho-type GTPase-activating protein 42
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:71544
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

644-795 (Predicted disordered autoinhibitory region) PR

644-795 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-B2RQE8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389022102	62	Q>H	No	EVA
rs3389024827	75	A>V	No	EVA
rs3399902053	86	S>*	No	EVA
rs3399597115	89	E>K	No	EVA
rs3399597153	102	R>H	No	EVA
rs3399782360	106	Q>K	No	EVA
rs3399797936	116	L>FEISQGVQLIHH*	No	EVA
rs3389028392	153	E>D	No	EVA
rs1133464658	184	A>V	No	EVA
rs49152858	207	S>T	No	EVA
rs3389028342	208	T>N	No	EVA
rs3389004118	307	F>V	No	EVA
rs3389022140	327	N>I	No	EVA
rs3389028360	355	Y>*	No	EVA
rs3389025507	375	G>C	No	EVA
rs3389019733	448	K>*	No	EVA
rs3389022501	480	H>R	No	EVA
rs3389022523	497	N>K	No	EVA
rs3389011375	500	V>I	No	EVA
rs3389025453	516	A>V	No	EVA
rs3389018797	646	W>R	No	EVA
rs3389028416	647	T>I	No	EVA
rs3389004045	736	I>K	No	EVA
rs3389028402	744	K>E	No	EVA
rs3389022133	746	C>R	No	EVA
rs47135914	782	V>L	No	EVA
rs3388998406	797	E>K	No	EVA
rs239110357	815	P>L	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for B2RQE8

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

Name	Definition
activation of GTPase activity	Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
negative regulation of Rho protein signal transduction	Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
negative regulation of systemic arterial blood pressure	The process that reduces the force with which blood travels through the systemic arterial circulatory system.
negative regulation of vascular associated smooth muscle contraction	Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZMW5	ARHGAP26	Rho GTPase-activating protein 26	Gallus gallus (Chicken)	PR
Q7YQL6	OPHN1	Oligophrenin-1	Pan troglodytes (Chimpanzee)	PR
O60890	OPHN1	Oligophrenin-1	Homo sapiens (Human)	PR
Q9UNA1	ARHGAP26	Rho GTPase-activating protein 26	Homo sapiens (Human)	PR
A6NI28	ARHGAP42	Rho GTPase-activating protein 42	Homo sapiens (Human)	PR
Q6ZQ82	Arhgap26	Rho GTPase-activating protein 26	Mus musculus (Mouse)	PR
Q99J31	Ophn1	Oligophrenin-1	Mus musculus (Mouse)	PR
P0CAX5	Ophn1	Oligophrenin-1	Rattus norvegicus (Rat)	PR
B5DFQ4	arhgap26	Rho GTPase-activating protein 26	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR