AiPD: Autoinhibited Protein Database

Q7L5N1

Gene name	COPS6 (CSN6, HVIP)
Protein name	COP9 signalosome complex subunit 6
Names	SGN6, Signalosome subunit 6, JAB1-containing signalosome subunit 6, MOV34 homolog, Vpr-interacting protein, hVIP
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10980
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-56 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

13 structures for Q7L5N1

Entry ID	Method	Resolution	Chain	Position	Source
4D10	X-ray	380 A	F/N	1-327	PDB
4D18	X-ray	408 A	F/N	1-327	PDB
4QFT	X-ray	176 A	A	31-211	PDB
4R14	X-ray	260 A	A/B	38-210	PDB
4WSN	X-ray	550 A	F/N/V/d/l/t	1-327	PDB
6R6H	EM	840 A	F	20-327	PDB
6R7F	EM	820 A	F	29-316	PDB
6R7H	EM	880 A	F	29-316	PDB
6R7I	EM	590 A	F	1-327	PDB
8H38	EM	425 A	F	1-327	PDB
8H3A	EM	751 A	F	1-327	PDB
8H3F	EM	673 A	F	1-327	PDB
AF-Q7L5N1-F1	Predicted				AlphaFoldDB

179 variants for Q7L5N1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
COSM1178831 CA174533 RCV000149188 rs193921011	211	S>R	Malignant tumor of prostate prostate [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar ExAC dbSNP gnomAD
CA4372832 rs374716476	2	A>V		No	ClinGen ESP ExAC gnomAD
rs1228878322 CA368429374	4	A>V		No	ClinGen TOPMed
CA163195714 rs1000687972	5	A>V		No	ClinGen TOPMed
rs777015230 CA163195720	6	A>S		No	ClinGen Ensembl
CA368429398 rs1359910995	6	A>V		No	ClinGen gnomAD
CA368429411 rs1400707667	7	A>V		No	ClinGen TOPMed gnomAD
CA368429415 rs1353523989	8	A>P		No	ClinGen TOPMed gnomAD
rs1353523989 CA368429413	8	A>T		No	ClinGen TOPMed gnomAD
rs1006414141 CA163195725	9	A>V		No	ClinGen TOPMed gnomAD
rs1032502671 CA163195728	11	T>M		No	ClinGen Ensembl
CA163195734 rs988198760	13	G>E		No	ClinGen gnomAD
rs1584478633 CA368429472	13	G>R		No	ClinGen Ensembl
CA368429499 rs1200520056	15	G>E		No	ClinGen TOPMed
rs1019287496 CA163195742	18	S>G		No	ClinGen Ensembl
CA368429541 rs965593420	18	S>I		No	ClinGen TOPMed
rs965593420 CA163195745	18	S>N		No	ClinGen TOPMed
rs778348350 CA4372837	19	G>R		No	ClinGen ExAC TOPMed gnomAD
CA368429600 rs1584478657	22	V>G		No	ClinGen Ensembl
rs1218205576 CA368429590	22	V>M		No	ClinGen TOPMed gnomAD
rs764511194 CA4372851	28	P>S		No	ClinGen ExAC gnomAD
CA4372852 rs753478190	30	V>L		No	ClinGen ExAC gnomAD
rs1185686302 CA368429760	33	C>S		No	ClinGen TOPMed
CA368429834 rs1584478800	38	S>R		No	ClinGen Ensembl
rs1481707252 CA368429859	41	V>I		No	ClinGen TOPMed
rs1262839910 CA368429881	42	A>V		No	ClinGen TOPMed gnomAD
CA368429887 rs1190593465	43	L>F		No	ClinGen gnomAD
rs1415114572 CA368429911	45	P>A		No	ClinGen gnomAD
CA163195880 rs1032204134	45	P>L		No	ClinGen Ensembl
CA368429924 rs1203992884	46	L>F		No	ClinGen TOPMed
rs997586354 CA163195894	54	H>Q		No	ClinGen TOPMed gnomAD
CA368430042 rs1448622232	59	R>H		No	ClinGen gnomAD
TCGA novel	60	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776623662 CA4372860	62	E>G		No	ClinGen ExAC gnomAD
rs1562888233 CA368430082	65	P>L		No	ClinGen Ensembl
CA4372879 rs781279064	73	I>T		No	ClinGen ExAC gnomAD
rs747857640 CA4372880	77	E>K		No	ClinGen ExAC gnomAD
TCGA novel	80	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368430226 rs1164637833	83	V>M		No	ClinGen gnomAD
CA368430364 rs565974418	93	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA4372884 rs565974418	93	T>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1584478934 CA368430376	94	V>M		No	ClinGen Ensembl
CA4372887 rs769114568	95	E>Q		No	ClinGen ExAC gnomAD
CA4372888 rs777221023	96	E>D		No	ClinGen ExAC gnomAD
CA4372889 rs762057075	98	I>F		No	ClinGen ExAC TOPMed gnomAD
rs765670713 CA4372890	98	I>M		No	ClinGen ExAC gnomAD
CA4372891 rs750043113	99	I>V		No	ClinGen ExAC
rs762726474 CA4372892	101	D>E		No	ClinGen ExAC TOPMed gnomAD
CA368430502 rs1395408819	103	E>K		No	ClinGen gnomAD
CA163196134 rs200385869	107	T>I		No	ClinGen 1000Genomes gnomAD
rs1584479257 CA368430769	115	V>G		No	ClinGen Ensembl
rs781393690 CA4372936	116	F>L		No	ClinGen ExAC gnomAD
CA368430895 rs1179213458	125	Y>H		No	ClinGen gnomAD
rs773625233 CA4372939	126	T>S		No	ClinGen ExAC gnomAD
rs1171597307 CA368430927	127	T>I		No	ClinGen gnomAD
CA4372940 rs749622502	128	G>A		No	ClinGen ExAC gnomAD
rs771471221 CA4372941	129	G>W		No	ClinGen ExAC gnomAD
rs376570259 CA163196676	130	P>S		No	ClinGen ESP
rs759319444 CA4372943	132	D>E		No	ClinGen ExAC gnomAD
rs370286743 CA4372944	134	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1253365202 CA368431046	137	H>Y		No	ClinGen gnomAD
CA4372948 rs766190524	138	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	141	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371629256	142	V>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	144	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1359812367 CA368431215	145	I>L		No	ClinGen gnomAD
TCGA novel	146	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4372977 rs756187791	148	S>I		No	ClinGen ExAC gnomAD
CA368432361 rs1447052366	151	F>L		No	ClinGen gnomAD
rs778057315 CA4372979	156	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1160104645 CA368432501	156	P>R		No	ClinGen TOPMed
rs778057315 CA368432491	156	P>S		No	ClinGen ExAC TOPMed gnomAD
CA368432522 rs1421041516	157	M>V		No	ClinGen TOPMed
CA368432577 rs1384605841	158	T>S		No	ClinGen gnomAD
CA368432613 rs1237306336	160	H>N		No	ClinGen TOPMed gnomAD
CA368432641 rs1584479392	160	H>Q		No	ClinGen Ensembl
rs1221166173 CA368432664	161	T>R		No	ClinGen gnomAD
TCGA novel	162	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753980345 CA4372980	162	D>V		No	ClinGen ExAC
rs1326114411 CA368432890	164	P>L		No	ClinGen gnomAD
CA368432878 rs1465584482	164	P>S		No	ClinGen TOPMed
rs1167813472 CA368432894	165	V>L		No	ClinGen Ensembl
rs779537986 CA4373000	167	V>I		No	ClinGen ExAC TOPMed gnomAD
CA4373003 rs780345066	174	I>R		No	ClinGen ExAC gnomAD
rs376706271 CA4373002	174	I>V		No	ClinGen ESP ExAC gnomAD
rs768233021 CA4373005	175	I>M		No	ClinGen ExAC gnomAD
rs780857138 CA4373006	176	N>S		No	ClinGen ExAC TOPMed gnomAD
CA368433286 rs1396816437	177	G>A		No	ClinGen gnomAD
rs1161103280 CA368433427	181	M>V		No	ClinGen TOPMed gnomAD
TCGA novel	182	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4373024 rs755360522	184	A>D		No	ClinGen ExAC gnomAD
CA4373027 rs373185695	195	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4373029 rs748834508	196	E>Q		No	ClinGen ExAC gnomAD
CA368433717 rs1355680735	197	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1262089538 CA368433910	208	A>T		No	ClinGen gnomAD
rs1430101038 CA368433934	209	T>I		No	ClinGen gnomAD
rs193921011 CA4373032	211	S>C		No	ClinGen ExAC gnomAD
rs193921011 CA368433957	211	S>G		No	ClinGen ExAC gnomAD
CA4373033 rs183823744	212	G>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1367570179 CA368433980	212	G>R		No	ClinGen gnomAD
CA4373035 rs762180235 COSM1093939	213	E>D	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs201466188 CA163197366	217	V>A		No	ClinGen 1000Genomes
rs372319928 CA163197387	218	A>T		No	ClinGen ESP TOPMed gnomAD
TCGA novel	219	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1255127705 CA368434147	222	I>M		No	ClinGen gnomAD
TCGA novel	223	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	224	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1238120086 CA368434169	225	H>Y		No	ClinGen TOPMed
CA368434221 rs1236013316	229	K>N		No	ClinGen gnomAD
rs1217802178 CA368434260	233	S>G		No	ClinGen TOPMed gnomAD
CA4373060 rs753019844	233	S>N		No	ClinGen ExAC gnomAD
rs558924563 CA4373062	235	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4373063 rs753564148	236	K>R		No	ClinGen ExAC gnomAD
rs1447900303 CA368434307	238	I>L		No	ClinGen Ensembl
CA368434331 rs1178807122	240	E>A		No	ClinGen TOPMed gnomAD
CA4373065 rs778539131	242	V>I		No	ClinGen ExAC gnomAD
CA368434360 rs1461529996	243	K>Q		No	ClinGen gnomAD
rs749963870 CA4373066	243	K>T		No	ClinGen ExAC TOPMed gnomAD
CA4373067 rs758347240	245	S>C		No	ClinGen ExAC TOPMed gnomAD
CA4373069 rs746754782	247	A>S		No	ClinGen ExAC gnomAD
CA4373092 rs747909039	248	G>A		No	ClinGen ExAC TOPMed gnomAD
rs1421867634 CA368434481	251	P>S		No	ClinGen gnomAD
rs779129074 CA4373094	255	E>K		No	ClinGen ExAC gnomAD
rs1426545007 CA368434540	258	R>Q		No	ClinGen gnomAD
rs769052117 CA4373099	261	Y>C		No	ClinGen ExAC gnomAD
rs747607635 CA4373098	261	Y>H		No	ClinGen ExAC gnomAD
CA4373101 rs762118429	262	A>S		No	ClinGen ExAC gnomAD
CA4373102 rs764936878	262	A>V		No	ClinGen ExAC
CA368434587 rs1315226074	263	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA368434616 rs1360963062	265	H>Q		No	ClinGen gnomAD
CA368434609 rs1168375830 COSM3833658	265	H>Y	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA4373105 rs200193790	273	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1446820005 CA368434690	273	D>H		No	ClinGen TOPMed gnomAD
rs1446820005 CA368434689	273	D>Y		No	ClinGen TOPMed gnomAD
CA4373107 rs754888968	276	K>E		No	ClinGen ExAC gnomAD
rs767362885 CA4373109	281	D>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	281	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368434836 rs1281756473	282	Q>P		No	ClinGen gnomAD
CA368434851 rs1223236912	283	C>F		No	ClinGen gnomAD
rs1344066280 CA368434847	283	C>R		No	ClinGen gnomAD
TCGA novel	284	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368434865 rs775484271	284	N>K		No	ClinGen ExAC TOPMed gnomAD
rs771547851 CA4373143	284	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1272457935 CA368434868	285	D>N		No	ClinGen TOPMed gnomAD
CA4373146 rs764018352 CA4373147	286	V>L		No	ClinGen ExAC gnomAD
CA368434886 rs1266639590	287	G>R		No	ClinGen gnomAD
TCGA novel	288	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368434907 rs1199806292	289	M>I		No	ClinGen gnomAD
CA4373148 rs761616256	289	M>V		No	ClinGen ExAC gnomAD
COSM1093944 CA4373149 rs766604429	290	A>T	lung Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1474260586 CA368434918	291	Y>C		No	ClinGen gnomAD
rs1166946102 CA368434923	292	L>V		No	ClinGen gnomAD
CA4373151 rs755086126	293	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA368434956 rs1404729717	297	K>R		No	ClinGen TOPMed gnomAD
CA368434963 rs1284248520	298	T>M		No	ClinGen gnomAD
rs1441479383 CA368434970	299	C>S		No	ClinGen TOPMed
rs1225589204 CA368434978	300	N>S		No	ClinGen gnomAD
rs749647179 CA4373156 COSM1453349	302	M>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed
rs778456150 CA4373155	302	M>V		No	ClinGen ExAC gnomAD
rs1801417 CA163197922	303	N>S		No	ClinGen Ensembl
CA368435003 rs1291639582	304	Q>E		No	ClinGen TOPMed
rs920559710 CA163197935	306	V>A		No	ClinGen TOPMed
CA163197933 rs973707596	306	V>M		No	ClinGen TOPMed
CA163197945 rs778623027	307	N>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel CA368435049 rs1584480266	310	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA368435061 rs1562889407	312	L>F		No	ClinGen Ensembl
CA368435067 rs1562889408	313	Y>N		No	ClinGen Ensembl
rs1584480281 CA368435079	314	D>E		No	ClinGen Ensembl
CA368435073 rs1223129586	314	D>N		No	ClinGen gnomAD
rs1223129586 CA368435075	314	D>Y		No	ClinGen gnomAD
rs1270852579 CA368435081	315	R>G		No	ClinGen gnomAD
CA368435098 rs1445043554	317	G>A		No	ClinGen TOPMed gnomAD
CA4373162 rs760206278	319	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1584480304 CA368435119	321	R>G		No	ClinGen Ensembl
rs761567342 CA4373165	322	M>T		No	ClinGen ExAC gnomAD
rs765013312 CA4373166	323	R>H		No	ClinGen ExAC gnomAD
CA368435155 rs1562889439	324	G>R		No	ClinGen Ensembl
rs1562889439 CA368435157	324	G>W		No	ClinGen Ensembl
CA368435173 rs1218259199	325	L>H		No	ClinGen TOPMed

No associated diseases with Q7L5N1

3 regional properties for Q7L5N1

Type	Name	Position	InterPro Accession
domain	JAB1/MPN/MOV34 metalloenzyme domain	40 - 173	IPR000555
domain	Rpn11/EIF3F, C-terminal	194 - 307	IPR024969
domain	MPN domain	41 - 174	IPR037518

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
COP9 signalosome	A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name	Definition
protein deneddylation	The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein neddylation	Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
regulation of protein neddylation	Any process that modulates the frequency, rate or extent of protein neddylation.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QQ21	COPS6	COP9 signalosome complex subunit 6	Bos taurus (Bovine)	PR
O00303	EIF3F	Eukaryotic translation initiation factor 3 subunit F	Homo sapiens (Human)	PR
O88545	Cops6	COP9 signalosome complex subunit 6	Mus musculus (Mouse)	PR
A7TX81	COPS6	COP9 signalosome complex subunit 6	Sus scrofa (Pig)	PR
Q07G98	cops6	COP9 signalosome complex subunit 6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MAAAAAAAAA	TNGTGGSSGM	EVDAAVVPSV	MACGVTGSVS	VALHPLVILN	ISDHWIRMRS
70	80	90	100	110	120
QEGRPVQVIG	ALIGKQEGRN	IEVMNSFELL	SHTVEEKIII	DKEYYYTKEE	QFKQVFKELE
130	140	150	160	170	180
FLGWYTTGGP	PDPSDIHVHK	QVCEIIESPL	FLKLNPMTKH	TDLPVSVFES	VIDIINGEAT
190	200	210	220	230	240
MLFAELTYTL	ATEEAERIGV	DHVARMTATG	SGENSTVAEH	LIAQHSAIKM	LHSRVKLILE
250	260	270	280	290	300
YVKASEAGEV	PFNHEILREA	YALCHCLPVL	STDKFKTDFY	DQCNDVGLMA	YLGTITKTCN
310	320
TMNQFVNKFN	VLYDRQGIGR	RMRGLFF