AiPD: Autoinhibited Protein Database

Gene name	Cops6 (Csn6)
Protein name	COP9 signalosome complex subunit 6
Names	SGN6, Signalosome subunit 6, JAB1-containing signalosome subunit 6
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:26893
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-51 (Predicted disordered autoinhibitory region) PR

1-51 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O88545-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388809056	27	V>M	No	EVA
rs3388791610	35	S>C	No	EVA
rs3388807480	77	N>D	No	EVA
rs3388809005	83	S>F	No	EVA
rs3388801906	86	L>M	No	EVA
rs3388801885	99	K>R	No	EVA
rs3388803883	108	Q>E	No	EVA
rs3388797828	115	E>G	No	EVA
rs3388801903	121	W>*	No	EVA
rs3388804157	145	S>C	No	EVA
rs3412833505	145	S>N	No	EVA
rs3388797854	161	P>S	No	EVA
rs3388791638	190	E>K	No	EVA
rs3388801944	193	E>Q	No	EVA
rs3388771548	214	V>L	No	EVA
rs3388809061	231	R>H	No	EVA
rs3388796630	245	G>E	No	EVA
rs3388801922	253	I>N	No	EVA
rs3388793731	255	R>W	No	EVA
rs3388791598	256	E>V	No	EVA
rs3388801612	265	P>R	No	EVA
rs3388796580	295	T>S	No	EVA

Type	Name	Position	InterPro Accession
domain	JAB1/MPN/MOV34 metalloenzyme domain	89 - 221	IPR000555
domain	Rpn11/EIF3F, C-terminal	244 - 354	IPR024969
domain	MPN domain	92 - 222	IPR037518

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
COP9 signalosome	A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
metallopeptidase activity	Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Name	Definition
protein deneddylation	The removal of a ubiquitin-like protein of the NEDD8 type from a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QQ21	COPS6	COP9 signalosome complex subunit 6	Bos taurus (Bovine)	PR
Q7L5N1	COPS6	COP9 signalosome complex subunit 6	Homo sapiens (Human)	PR
A7TX81	COPS6	COP9 signalosome complex subunit 6	Sus scrofa (Pig)	PR
Q07G98	cops6	COP9 signalosome complex subunit 6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR