A7TX81

PR
Gene name
COPS6
Protein name
COP9 signalosome complex subunit 6
Names
SGN6, Signalosome subunit 6
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:100125954
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7TX81

Entry ID Method Resolution Chain Position Source
AF-A7TX81-F1 Predicted AlphaFoldDB

No variants for A7TX81

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7TX81

No associated diseases with A7TX81

3 regional properties for A7TX81

Type Name Position InterPro Accession
domain JAB1/MPN/MOV34 metalloenzyme domain 36 - 169 IPR000555
domain Rpn11/EIF3F, C-terminal 190 - 303 IPR024969
domain MPN domain 37 - 170 IPR037518

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

1 GO annotations of biological process

Name Definition
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQ21 COPS6 COP9 signalosome complex subunit 6 Bos taurus (Bovine) PR
Q7L5N1 COPS6 COP9 signalosome complex subunit 6 Homo sapiens (Human) PR
O88545 Cops6 COP9 signalosome complex subunit 6 Mus musculus (Mouse) PR
Q07G98 cops6 COP9 signalosome complex subunit 6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAAAAAANGT GGSSGMEVDA AVVPSVMASG VTGSVSVALH PLVILNISDH WIRMRSQEGR
70 80 90 100 110 120
PMQVIGALIG KQEGRNIEVM NSFELLSHTV EEKIIIDKEY YYTKEEQFKQ VFKELEFLGW
130 140 150 160 170 180
YTTGGPPDPS DIHVHKQVCE IIESPLFLKL NPMTKHTDLP VSVFESVIDI INGEATMLFA
190 200 210 220 230 240
ELTYTLATEE AERIGVDHVA RMTATGSGEN STVAEHLIAQ HSAIKMLHSR VKLILEYVKA
250 260 270 280 290 300
SEAGEVPFNH EILREAYALC HCLPVLSTDK FKTDFYDQCN DVGLMAYLGT ITKTCNTMNQ
310 320
FVNKFNVLYD RQGIGRRMRG LFF