Q07G98

PR
Gene name
cops6 (csn6, TNeu117c08.1)
Protein name
COP9 signalosome complex subunit 6
Names
Signalosome subunit 6
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:448375
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q07G98

Entry ID Method Resolution Chain Position Source
AF-Q07G98-F1 Predicted AlphaFoldDB

No variants for Q07G98

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q07G98

No associated diseases with Q07G98

3 regional properties for Q07G98

Type Name Position InterPro Accession
domain JAB1/MPN/MOV34 metalloenzyme domain 31 - 165 IPR000555
domain Rpn11/EIF3F, C-terminal 186 - 299 IPR024969
domain MPN domain 33 - 166 IPR037518

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

1 GO annotations of biological process

Name Definition
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQ21 COPS6 COP9 signalosome complex subunit 6 Bos taurus (Bovine) PR
Q7L5N1 COPS6 COP9 signalosome complex subunit 6 Homo sapiens (Human) PR
O88545 Cops6 COP9 signalosome complex subunit 6 Mus musculus (Mouse) PR
A7TX81 COPS6 COP9 signalosome complex subunit 6 Sus scrofa (Pig) PR
10 20 30 40 50 60
MAAAAASNGS GMEVDVAAFP TVMAQGVTGS VTVALHPLVI LNISDHWIRM RSQEGRPVQV
70 80 90 100 110 120
IGALIGKQEG RNIEVMNSFE LLSQINEEKI TINKEYYYTK EEQFKQVFKD MEFLGWYTTG
130 140 150 160 170 180
GTPDPSDIHV HKQVCEIIES PLFLKLNPMT KHTDLPVSVY ESVIDIVNGE ATMLLAELSY
190 200 210 220 230 240
TLATEEAERI GVDHVARMTA TGSGENSTVA EHLIAQHSAI KMLHSRVRLI LEYVRAAEAG
250 260 270 280 290 300
EVPFNHEILR EASALCHCLP VLSTDKFKMD FYDQCNDVGL MSYLGTITKT CNTMNQFVNK
310
FNILYDRQGI GRRMRGLFF