Q7G188
PR
Gene name |
FIM1 |
Protein name |
Fimbrin-1 |
Names |
AtFIM1, Fimbrin1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G26700 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q7G188
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1PXY | X-ray | 240 A | A/B | 123-623 | PDB |
| AF-Q7G188-F1 | Predicted | AlphaFoldDB |
53 variants for Q7G188
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_13463833_C_G | 25 | T>S | No | 1000Genomes | |
| tmp_4_13463981_C_T | 50 | A>V | No | 1000Genomes | |
| tmp_4_13464002_C_G | 57 | A>G | No | 1000Genomes | |
| tmp_4_13464029_G_A | 66 | G>D | No | 1000Genomes | |
| tmp_4_13464050_C_T | 73 | S>F | No | 1000Genomes | |
| tmp_4_13464064_G_A | 78 | D>N | No | 1000Genomes | |
| ENSVATH06781275 | 91 | L>S | No | 1000Genomes | |
| ENSVATH12246920 | 97 | E>A | No | 1000Genomes | |
| tmp_4_13464289_A_T | 120 | T>S | No | 1000Genomes | |
| ENSVATH06781276 | 155 | Q>E | No | 1000Genomes | |
| tmp_4_13464551_G_T | 179 | D>Y | No | 1000Genomes | |
| tmp_4_13464578_G_T | 188 | V>L | No | 1000Genomes | |
| ENSVATH14299847 | 219 | D>Y | No | 1000Genomes | |
| ENSVATH00539911 | 240 | V>L | No | 1000Genomes | |
| ENSVATH00539913 | 264 | E>D | No | 1000Genomes | |
| tmp_4_13465168_C_A | 293 | N>K | No | 1000Genomes | |
| ENSVATH00539919 | 332 | L>M | No | 1000Genomes | |
| ENSVATH12247022 | 361 | A>G | No | 1000Genomes | |
| ENSVATH06781291 | 374 | N>I | No | 1000Genomes | |
| ENSVATH00539925 | 375 | K>T | No | 1000Genomes | |
| ENSVATH12247075 | 377 | G>C | No | 1000Genomes | |
| tmp_4_13465988_C_A | 380 | A>E | No | 1000Genomes | |
| ENSVATH06781292 | 380 | A>S | No | 1000Genomes | |
| tmp_4_13466014_G_A | 389 | V>I | No | 1000Genomes | |
| ENSVATH06781293 | 391 | T>N | No | 1000Genomes | |
| ENSVATH12247076 | 399 | R>Q | No | 1000Genomes | |
| ENSVATH06781294 | 409 | S>N | No | 1000Genomes | |
| tmp_4_13466089_G_A | 414 | V>I | No | 1000Genomes | |
| ENSVATH06781298 | 423 | I>M | No | 1000Genomes | |
| tmp_4_13466276_A_G | 429 | D>G | No | 1000Genomes | |
| tmp_4_13466309_A_C | 440 | H>P | No | 1000Genomes | |
| ENSVATH00539928 | 460 | I>V | No | 1000Genomes | |
| tmp_4_13466413_G_A | 475 | G>R | No | 1000Genomes | |
| tmp_4_13466425_G_C | 479 | V>L | No | 1000Genomes | |
| ENSVATH00539930 | 491 | W>G | No | 1000Genomes | |
| ENSVATH00539932 | 513 | E>D | No | 1000Genomes | |
| tmp_4_13466815_G_A | 543 | S>N | No | 1000Genomes | |
| tmp_4_13466820_T_C | 545 | S>P | No | 1000Genomes | |
| ENSVATH06781307 | 551 | L>V | No | 1000Genomes | |
| tmp_4_13466892_A_G | 569 | K>E | No | 1000Genomes | |
| ENSVATH06781310 | 577 | R>K | No | 1000Genomes | |
| ENSVATH06781310 | 577 | R>M | No | 1000Genomes | |
| tmp_4_13467022_A_G | 581 | T>A | No | 1000Genomes | |
| ENSVATH06781312 | 616 | I>V | No | 1000Genomes | |
| tmp_4_13467275_C_T | 638 | T>I | No | 1000Genomes | |
| tmp_4_13467289_A_G | 643 | S>G | No | 1000Genomes | |
| ENSVATH12247084 | 649 | A>T | No | 1000Genomes | |
| ENSVATH14299853 | 649 | A>V | No | 1000Genomes | |
| tmp_4_13467310_C_A | 650 | P>T | No | 1000Genomes | |
| ENSVATH02927939 | 658 | V>A | No | 1000Genomes | |
| tmp_4_13467334_G_C | 658 | V>L | No | 1000Genomes | |
| ENSVATH00539938 | 662 | S>R | No | 1000Genomes | |
| tmp_4_13467373_G_A | 671 | G>S | No | 1000Genomes |
No associated diseases with Q7G188
6 regional properties for Q7G188
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Actinin-type actin-binding domain, conserved site | 212 - 236 | IPR001589-1 |
| conserved_site | Actinin-type actin-binding domain, conserved site | 470 - 494 | IPR001589-2 |
| domain | Calponin homology domain | 123 - 240 | IPR001715-1 |
| domain | Calponin homology domain | 268 - 371 | IPR001715-2 |
| domain | Calponin homology domain | 392 - 498 | IPR001715-3 |
| domain | Calponin homology domain | 513 - 621 | IPR001715-4 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin filament | A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. |
| actin filament bundle | An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament bundle assembly | The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. |
| actin filament network formation | The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
4 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGYVGVVVS | DPWLQSQFTQ | VELRTLNSKY | VSVKNQNGKV | TIEDLPPLFA | KLKALSATFK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDEIKGMLGE | LGSDTSTDVS | FEEFLKIYLN | LLSKAAEKSG | GHHKNSSSFL | KACTTTLLHT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IYQSEKGPFV | QHINRYLGDD | PFLKQFLPLD | PHSNQLYELV | KDGVLLCKLI | NVAVPGTIDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RAINTKRVLN | PWERNENHTL | CLNSAKAVGC | SVVNIGTQDL | AEGRPHLVLG | LISQLIKIQV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LADLNLKKTP | QLVELLEDSD | DVEELLRLPP | EKVLLKWMNF | HLKKGGYKKT | VSNFSADLKD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AQAYAFLLNV | LAPEHCDPAT | LDAKDPLERA | ELVLSHAERM | NCKRYLTAEE | IVEGSSTLNL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFVAQIFHER | NGLNKDGKYA | FAEMMTEDVE | TCRDERCYRL | WINSLGIDSY | VNNVFEDVRN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GWILLEVLDK | VSPSSVNWKH | ASKPPIKMPF | RKVENCNQVI | KIGKQLKFSL | VNVAGNDIVQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GNKKLILGLL | WQLMRFHMLQ | LLKSLRSRTL | GKEMTDADIL | SWANRKVRTM | GRKLQIESFK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DKSLSSGLFF | LNLLWAVEPR | VVNWNLVTKG | ETDDEKRLNA | TYIVSVARKL | GCSVFLLPED |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IVEVNQKMIL | ILTASIMYWS | LQRHSRESSD | SSSTQSTTTT | CTSTASSPAP | SVTEEEEVSS |
| 670 | 680 | ||||
| LSGEVTSLAV | GDAVSEITTV | SEEASIE |