Q6PGK7

PR
Gene name
Chst10
Protein name
Carbohydrate sulfotransferase 10
Names
HNK-1 sulfotransferase, HNK-1ST, HNK1ST
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:98388
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6PGK7

Entry ID Method Resolution Chain Position Source
AF-Q6PGK7-F1 Predicted AlphaFoldDB

18 variants for Q6PGK7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389864603 5 W>* No EVA
rs3389867359 10 A>T No EVA
rs3388464739 23 K>M No EVA
rs3388465196 39 Q>H No EVA
rs254971607 39 Q>K No EVA
rs3388465047 41 F>Y No EVA
rs3388465527 58 H>Y No EVA
rs3388466183 96 A>T No EVA
rs3388467315 154 N>K No EVA
rs3388467262 156 V>I No EVA
rs3388464833 165 P>S No EVA
rs3389882828 218 A>G No EVA
rs3388465982 242 R>C No EVA
rs3388465867 242 R>H No EVA
rs3389854075 253 D>V No EVA
rs3389882799 255 Q>R No EVA
rs3388465370 271 A>V No EVA
rs3388464874 278 S>G No EVA

No associated diseases with Q6PGK7

No regional properties for Q6PGK7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6PGK7

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
HNK-1 sulfotransferase activity Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R).
sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

6 GO annotations of biological process

Name Definition
androgen metabolic process The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
long-term memory The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O43529 CHST10 Carbohydrate sulfotransferase 10 Homo sapiens (Human) PR
O54702 Chst10 Carbohydrate sulfotransferase 10 Rattus norvegicus (Rat) PR
Q6AXM1 chst10 Carbohydrate sulfotransferase 10 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MHHQWLLLAA CFWVIFMFMV ASKFITLTFK DPDGYSAKQE FVFLTTMPEA EKLRGEKHFP
70 80 90 100 110 120
EVPKPTGKML SDSRPDQPPV YLERLELIRN TCKEEALRNL SHTEVSKFVL DRIFVCDKHK
130 140 150 160 170 180
ILFCQTPKVG NTQWKKVLIV LNGAFSSIEE IPENVVHDHE KNGLPRLSSF SKIGIQKRLK
190 200 210 220 230 240
TYFKFFIVRD PFERLISAFK DKFVHNPRFE PWYRHEIAPG IIRKYRKNRT ETRGIQFEDF
250 260 270 280 290 300
VRYLGDPNRR WLDLQFGDHI IHWVTYVELC APCEIKYSVV GHHETLEADA PYILKEAGID
310 320 330 340 350
HLVSYPTIPP GITMYNRTKV EQYFLGISKR DIRRLYARFE GDFKLFGYQK PDFLLN