Q6P806

PR
Gene name
samm50
Protein name
Sorting and assembly machinery component 50 homolog
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:394743
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P806

Entry ID Method Resolution Chain Position Source
AF-Q6P806-F1 Predicted AlphaFoldDB

No variants for Q6P806

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P806

No associated diseases with Q6P806

2 regional properties for Q6P806

Type Name Position InterPro Accession
domain Mediator complex, subunit Med25, PTOV domain 90 - 238 IPR021394-1
domain Mediator complex, subunit Med25, PTOV domain 255 - 399 IPR021394-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
SAM complex A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cristae formation The assembly of cristae, the inwards folds of the inner mitochondrial membrane.
mitochondrial respiratory chain complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.
protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2HJ55 SAMM50 Sorting and assembly machinery component 50 homolog Bos taurus (Bovine) PR
Q9V784 CG7639 SAM50-like protein CG7639 Drosophila melanogaster (Fruit fly) PR
Q9Y512 SAMM50 Sorting and assembly machinery component 50 homolog Homo sapiens (Human) PR
Q8BGH2 Samm50 Sorting and assembly machinery component 50 homolog Mus musculus (Mouse) PR
Q6AXV4 Samm50 Sorting and assembly machinery component 50 homolog Rattus norvegicus (Rat) PR
Q5U3I0 samm50b Sorting and assembly machinery component 50 homolog B Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q803G5 samm50a Sorting and assembly machinery component 50 homolog A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGTVHARSLD PLPMNGPDFG SHDDADLVEV EPQKKQEILE NKDVVVQRVH FEGLGRTKDD
70 80 90 100 110 120
LIAHEIGQVF KAKNLIEVMR KSHEAREKLL RLGVFRNVEV LIDTCEGEDA LPNGLDVTFE
130 140 150 160 170 180
VTELRRLTGS YNTMVGNNEG SMVLGLKLPN LFGRAEKMTF QFSYGTKETS YGLSFFKPQV
190 200 210 220 230 240
GNFERNFSVN LYKVTGQFPW SSLRETDRGV SAEINFPIWK TSHTLKWEGV WRELGCLART
250 260 270 280 290 300
ASFAIREESG HTLKSSLSHT MVIDSRNTSI LPKRGALLKI NQELAGYTGG DVSFLKEDFE
310 320 330 340 350 360
LQLNKQLAWD SVLSTSLWGG MLVPIGDKPS SIADRFYLGG PTSVRGFSMY SIGPQSEGDY
370 380 390 400 410 420
LGGEAYWAGG MHLYTPLPFR PGRGGFGDLF RTHFFLNAGN LCNLNYGEGP RAHLRRLAEC
430 440 450 460
IRWSYGAGIV LRLGNIARLE LNYCIPMGVQ SGDRICDGVQ FGAGIRFL