Q2HJ55

PR
Gene name
SAMM50
Protein name
Sorting and assembly machinery component 50 homolog
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:618777
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HJ55

Entry ID Method Resolution Chain Position Source
AF-Q2HJ55-F1 Predicted AlphaFoldDB

73 variants for Q2HJ55

Variant ID(s) Position Change Description Diseaes Association Provenance
rs456646256 51 H>N No EVA
rs480686565 164 S>P No EVA
rs451176594 217 F>Y No EVA
rs469500520 219 T>P No EVA
rs449539544 220 W>G No EVA
rs480960376 221 K>N No EVA
rs467101660 222 T>A No EVA
rs467101660 222 T>P No EVA
rs469788378 222 T>R No EVA
rs478329578 223 S>G No EVA
rs458262528 223 S>R No EVA
rs482260381 227 K>Q No EVA
rs462143053 227 K>R No EVA
rs442654625 228 W>G No EVA
rs474144512 229 E>V No EVA
rs453817240 231 V>F No EVA
rs440220245 231 V>G No EVA
rs453817240 231 V>L No EVA
rs451338588 232 W>C No EVA
rs471295106 232 W>G No EVA
rs437554080 234 E>* No EVA
rs455340050 234 E>D No EVA
rs468759849 234 E>G No EVA
rs435854987 235 L>V No EVA
rs467317663 237 C>Y No EVA
rs446986789 239 S>Y No EVA
rs478443071 241 V>A No EVA
rs478443071 241 V>G No EVA
rs464655746 243 S>A No EVA
rs482323757 244 F>S No EVA
rs442030505 246 V>G No EVA
rs462108214 246 V>L No EVA
rs480552491 248 K>E No EVA
rs460492560 249 E>D No EVA
rs440188371 250 S>G No EVA
rs471459523 254 L>M No EVA
rs475327070 259 S>L No EVA
rs434446158 315 S>C No EVA
rs477093282 332 S>N No EVA
rs462738691 337 F>L No EVA
rs442448974 338 Y>S No EVA
rs472072001 351 H>P No EVA
rs472072001 351 H>R No EVA
rs451934656 352 S>G No EVA
rs438294312 352 S>R No EVA
rs445134882 384 Q>P No EVA
rs468193725 409 E>Q No EVA
rs480180481 411 P>S No EVA
rs480180481 411 P>T No EVA
rs446303569 412 K>N No EVA
rs466436578 412 K>R No EVA
rs477448146 414 H>D No EVA
rs463771283 414 H>P No EVA
rs441151433 419 A>T No EVA
rs472578735 420 E>* No EVA
rs459690373 420 E>A No EVA
rs439475565 421 C>G No EVA
rs470812225 422 I>V No EVA
rs457100826 431 V>G No EVA
rs436907325 437 I>M No EVA
rs474660065 444 Y>F No EVA
rs454444065 445 C>R No EVA
rs465715429 446 V>D No EVA
rs434422228 446 V>F No EVA
rs470230165 448 M>R No EVA
rs432625383 448 M>V No EVA
rs481326681 450 V>E No EVA
rs481326681 450 V>G No EVA
rs450159697 450 V>L No EVA
rs447681597 451 Q>E No EVA
rs479093965 451 Q>P No EVA
rs458860923 452 R>H No EVA
rs463561990 455 R>T No EVA

No associated diseases with Q2HJ55

2 regional properties for Q2HJ55

Type Name Position InterPro Accession
domain Bacterial surface antigen (D15) 151 - 468 IPR000184
domain POTRA domain 45 - 125 IPR034746

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Multi-pass membrane protein
  • Cytoplasm
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
SAM complex A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cristae formation The assembly of cristae, the inwards folds of the inner mitochondrial membrane.
mitochondrial respiratory chain complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.
protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9V784 CG7639 SAM50-like protein CG7639 Drosophila melanogaster (Fruit fly) PR
Q9Y512 SAMM50 Sorting and assembly machinery component 50 homolog Homo sapiens (Human) PR
Q8BGH2 Samm50 Sorting and assembly machinery component 50 homolog Mus musculus (Mouse) PR
Q6AXV4 Samm50 Sorting and assembly machinery component 50 homolog Rattus norvegicus (Rat) PR
Q6P806 samm50 Sorting and assembly machinery component 50 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q5U3I0 samm50b Sorting and assembly machinery component 50 homolog B Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q803G5 samm50a Sorting and assembly machinery component 50 homolog A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGTVHARSLE PLPASGPDFG ALGEEAEFVE VEPEAKQEIL ENKDVVVQHV HFDGLGRTKD
70 80 90 100 110 120
DIIMYEIRDV FKAKNLIEVM RKSHEAREKL LRLGIFRQVD VLIDTCQGDD ALPNGLDVTF
130 140 150 160 170 180
EVTELRRLTG SYNTMVGNNE GSMVLGLKLP NLLGRAEKVT FQFSYGTKET SYGLSFFKPQ
190 200 210 220 230 240
PGNFDRNFSV NLYKVTGQFP WSSLRETDRG VSAEYSFPTW KTSHTVKWEG VWRELGCLSR
250 260 270 280 290 300
VASFAVRKES GHSLKSSLSH SMVIDSRNSS ILPKRGALLK VNQELAGYTG GDVSFLKEDF
310 320 330 340 350 360
ELQLNKQLIL DTVFSASLWG GMLVPMGDKP SSIADRFYLG GPTSVRGFSM HSVGPQSEGD
370 380 390 400 410 420
YLGGEAYWAG GLHLYTPLPF RPGQGGFGEL FRTHFFLNAG NLCNLNYGEG PKAHIRKLAE
430 440 450 460
CIRWSYGAGI VLRLGNIARL ELNYCVPMGV QRGDRICDGV QFGAGIRFL