AiPD: Autoinhibited Protein Database

Gene name	Atg16l2
Protein name	Protein Atg16l2
Names	APG16-like 2, Autophagy-related protein 16-2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:73683
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

33-309 (Predicted disordered autoinhibitory region) PR

33-309 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6KAU8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs864288448	41	P>R	No	EVA
rs3388912058	62	S>Y	No	EVA
rs235925592	72	H>R	No	EVA
rs3397941431	83	G>V	No	EVA
rs3388923852	127	S>L	No	EVA
rs213791128	167	Q>L	No	EVA
rs3388932799	180	H>P	No	EVA
rs3388931154	181	Q>L	No	EVA
rs3388902587	189	Q>L	No	EVA
rs3388923876	190	E>V	No	EVA
rs3388935086	220	A>S	No	EVA
rs3388907658	222	Q>H	No	EVA
rs3388928915	223	A>S	No	EVA
rs248951832	241	E>K	No	EVA
rs265003745	247	E>*	No	EVA
rs246109537	247	E>V	No	EVA
rs249793905	261	A>T	No	EVA
rs3388926477	268	S>N	No	EVA
rs3388907612	309	V>*	No	EVA
rs3388923062	310	G>V	No	EVA
rs3388917191	327	Q>*	No	EVA
rs3388935055	360	A>T	No	EVA
rs3388902661	372	G>S	No	EVA
rs3388923834	438	R>M	No	EVA
rs3388907652	462	R>K	No	EVA
rs3388917153	505	V>M	No	EVA
rs220287593	532	V>I	No	EVA
rs3388912032	535	L>M	No	EVA
rs224067804	575	D>N	No	EVA
rs3388907634	584	G>W	No	EVA
rs3388923800	591	Q>*	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	329 - 493	IPR001680-1
repeat	WD40 repeat	496 - 534	IPR001680-2
repeat	WD40 repeat	539 - 623	IPR001680-3
domain	Autophagy-related protein 16 domain	20 - 211	IPR013923
conserved_site	WD40 repeat, conserved site	355 - 369	IPR019775-1
conserved_site	WD40 repeat, conserved site	567 - 581	IPR019775-2
repeat	G-protein beta WD-40 repeat	355 - 369	IPR020472-1
repeat	G-protein beta WD-40 repeat	441 - 455	IPR020472-2
repeat	G-protein beta WD-40 repeat	480 - 494	IPR020472-3

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol	Localizes also to discrete punctae along the ciliary axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Atg12-Atg5-Atg16 complex	A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.
autophagosome membrane	The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
phagophore assembly site membrane	A cellular membrane associated with the phagophore assembly site.

Name	Definition
No GO annotations for molecular function

Name	Definition
autophagosome assembly	The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
macroautophagy	The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
negative stranded viral RNA replication	A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
protein lipidation	The covalent attachment of lipid groups to an amino acid in a protein.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q676U5	ATG16L1	Autophagy-related protein 16-1	Homo sapiens (Human)	PR
Q8NAA4	ATG16L2	Protein Atg16l2	Homo sapiens (Human)	PR
Q8C0J2	Atg16l1	Autophagy-related protein 16-1	Mus musculus (Mouse)	PR
Q09406	atg-16.2	Autophagic-related protein 16.2	Caenorhabditis elegans	PR