Q6DJ48

PR
Gene name
stn1
Protein name
CST complex subunit STN1
Names
Oligonucleotide/oligosaccharide-binding fold-containing protein 1, Suppressor of cdc thirteen homolog
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:448268
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-144 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DJ48

Entry ID Method Resolution Chain Position Source
AF-Q6DJ48-F1 Predicted AlphaFoldDB

No variants for Q6DJ48

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DJ48

No associated diseases with Q6DJ48

4 regional properties for Q6DJ48

Type Name Position InterPro Accession
domain Ribonuclease III domain 875 - 1078 IPR000999-1
domain Ribonuclease III domain 1106 - 1253 IPR000999-2
domain Double-stranded RNA-binding domain 1259 - 1333 IPR014720
domain RNase III, double-stranded RNA binding domain, animal 1258 - 1331 IPR044442

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, telomere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
CST complex A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
single-stranded DNA binding Binding to single-stranded DNA.
single-stranded telomeric DNA binding Binding to single-stranded telomere-associated DNA.

3 GO annotations of biological process

Name Definition
telomere capping A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
telomere maintenance via telomere lengthening Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q13156 RPA4 Replication protein A 30 kDa subunit Homo sapiens (Human) PR
P15927 RPA2 Replication protein A 32 kDa subunit Homo sapiens (Human) PR
Q9ZQ19 RPA2A Replication protein A 32 kDa subunit A Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MQPASLEETP SLLWGLDPIF LAFAKLYIKD ILELKESQQV PGIFFYRGHP IKQVDVLGTV
70 80 90 100 110 120
VFVREKENFY SYGVDDSTGV ISCTCWKSTA PTEVSSPGTS ARHVSSSSKD LDVMMRELYK
130 140 150 160 170 180
EESKKAKLDI GDTIRVRGSI KVFRDQREIV ASVFYKVEDP KLDIQMARMF DLPYMYRNVY
190 200 210 220 230 240
DKPFAIPEHL KDSSAGQTDH HIVTQSHLIM LLSEKVKVFL MENKIHNFYQ RELESVDSLI
250 260 270 280 290 300
AIASRPVSDF KTIESMESSN SKQIRSIFKE AIQLLLKEGY IFQKDQNREV YQVTDQDKDL
310 320 330 340 350 360
HKLTLNIIKE DCRRQKHAEK GCHFLHILTC VRLSVGSSVS EAVLRRVIDT LEGNSDIVST
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