AiPD: Autoinhibited Protein Database

P15927

Gene name	RPA2 (REPA2, RPA32, RPA34)
Protein name	Replication protein A 32 kDa subunit
Names	RP-A p32, Replication factor A protein 2, RF-A protein 2, Replication protein A 34 kDa subunit, RP-A p34
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6118
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-68 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

11 structures for P15927

Entry ID	Method	Resolution	Chain	Position	Source
1DPU	NMR	-	A	172-270	PDB
1L1O	X-ray	280 A	B/E	44-171	PDB
1QUQ	X-ray	250 A	A/C	43-171	PDB
1Z1D	NMR	-	A	172-270	PDB
2PI2	X-ray	200 A	A/B/C/D	1-270	PDB
2PQA	X-ray	250 A	A/C	42-172	PDB
2Z6K	X-ray	300 A	A/B	1-270	PDB
3KDF	X-ray	198 A	B/D	41-172	PDB
4MQV	X-ray	195 A	A/C	202-270	PDB
4OU0	X-ray	140 A	A	202-270	PDB
AF-P15927-F1	Predicted				AlphaFoldDB

202 variants for P15927

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs777779644 CA718358	3	N>K		No	ClinGen ExAC gnomAD
rs765854928 CA718302	4	S>I		No	ClinGen ExAC gnomAD
CA339477499 rs765854928	4	S>N		No	ClinGen ExAC gnomAD
TCGA novel CA19944102 rs898160262	6	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
CA718301 rs757873922	8	S>N		No	ClinGen ExAC gnomAD
CA339477463 rs1201286242	9	Y>C		No	ClinGen TOPMed
rs1273358149 CA339477458	10	G>R		No	ClinGen TOPMed
rs761614333 CA718298	11	S>R		No	ClinGen ExAC gnomAD
rs776471331 CA718297	12	S>F		No	ClinGen ExAC TOPMed gnomAD
rs776471331 CA339477443	12	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA718296 rs201492173	13	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA19944074 rs28988896 VAR_023300	14	Y>S		No	ClinGen UniProt Ensembl dbSNP
CA718292 VAR_023301 rs28988897 CA339477429	15	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD UniProt dbSNP
rs28988897 CA718293	15	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA718291 rs148430221	16	G>R		No	ClinGen ESP ExAC gnomAD
rs1248396349 CA339477420	17	A>T		No	ClinGen gnomAD
rs770197869 CA718289	18	G>R		No	ClinGen ExAC gnomAD
CA339477395 rs748375829	21	T>A		No	ClinGen ExAC TOPMed gnomAD
rs781718215 CA718287	21	T>M		No	ClinGen ExAC gnomAD
rs748375829 CA718288	21	T>P		No	ClinGen ExAC TOPMed gnomAD
COSM184564 rs755345876 COSM184563 CA718286	23	S>F	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs755345876 CA339477379	23	S>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	26	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA718284 rs780566579	26	G>S		No	ClinGen ExAC gnomAD
CA339477362 rs1557477543	26	G>V		No	ClinGen Ensembl
rs771264048	27	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs369007762 CA718282	27	F>Y		No	ClinGen ESP ExAC gnomAD
rs1167754276 CA339477344	29	S>*		No	ClinGen TOPMed
CA339477343 rs1167754276	29	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs199857202 CA19943973	30	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs199857202 CA718281	30	P>T		No	ClinGen 1000Genomes ExAC gnomAD
CA339477338 rs1571627682	31	A>T		No	ClinGen Ensembl
CA718280 rs149249571	33	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA339477320 rs1363445599	34	Q>E		No	ClinGen gnomAD
CA339477318 rs1157119942	34	Q>P		No	ClinGen gnomAD
CA718279 rs756974840	35	A>T		No	ClinGen ExAC gnomAD
rs1193999593 CA339477299	37	K>E		No	ClinGen gnomAD
CA339477281 rs1251048763	39	S>L		No	ClinGen gnomAD
CA19938814 rs962234142	40	R>G		No	ClinGen TOPMed
CA339252884 rs1277423591	41	A>D		No	ClinGen gnomAD
rs1346102564 CA339252887	41	A>S		No	ClinGen gnomAD
rs755866319 CA19938806	42	R>*		No	ClinGen ExAC TOPMed gnomAD
rs1225165257 CA339252877	43	A>T		No	ClinGen gnomAD
CA718256 rs752479657	43	A>V		No	ClinGen ExAC TOPMed gnomAD
rs781090246 CA19938788	44	Q>E		No	ClinGen Ensembl
CA718255 rs767211752	49	C>S		No	ClinGen ExAC gnomAD
rs1225327354 CA339252827	50	T>S		No	ClinGen TOPMed
CA718254 rs540849246	51	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1317288814 CA339252816	52	S>F		No	ClinGen TOPMed gnomAD
CA19938767 rs1050563630	58	T>S		No	ClinGen TOPMed
CA19938763 rs5030742	59	L>V		No	ClinGen Ensembl
rs367965034 CA718253	59	L>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA19938753 rs376928504	61	D>E		No	ClinGen ESP TOPMed
CA339252737 rs1372414426	65	R>G		No	ClinGen gnomAD
rs1190481788 CA339252734	65	R>T		No	ClinGen gnomAD
rs776720485 CA718250	73	Q>E		No	ClinGen ExAC gnomAD
rs1382280006 CA339252677	73	Q>H		No	ClinGen gnomAD
CA339252660 rs1280290919	74	V>D		No	ClinGen gnomAD
rs1341377467 CA339252656	75	T>A		No	ClinGen TOPMed
CA718218 rs146039555	76	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA339252633 rs1443066950	79	I>F		No	ClinGen gnomAD
CA19938573 rs5030750	79	I>N		No	ClinGen Ensembl
CA718215 rs771369613	80	I>T		No	ClinGen ExAC gnomAD
rs1324707342 CA339252612	82	H>Y		No	ClinGen gnomAD
TCGA novel	84	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1419388190 CA339252599	84	E>Q		No	ClinGen TOPMed gnomAD
CA339252570 rs1316740579	88	T>A		No	ClinGen TOPMed
rs1158735496 CA339252565	89	N>D		No	ClinGen gnomAD
rs1469972602 CA339252557	90	I>V		No	ClinGen gnomAD
rs1362459002 CA339252536	93	K>E		No	ClinGen gnomAD
CA19938551 rs981230684	94	I>T		No	ClinGen TOPMed gnomAD
rs371117106 CA718213	95	D>N		No	ClinGen ESP ExAC gnomAD
TCGA novel	95	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA718211 rs747856894	97	M>K		No	ClinGen ExAC TOPMed gnomAD
rs1448750353 CA339252508	97	M>V		No	ClinGen gnomAD
rs558257017 CA718210	100	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs148706559 CA19938528 COSM107725 COSM107726	102	M>I	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1277607207 CA339252453	102	M>V		No	ClinGen gnomAD
rs111497606 CA19938523	104	V>A		No	ClinGen Ensembl
rs746740719 CA718208	104	V>I		No	ClinGen ExAC TOPMed gnomAD
CA339252420 rs1371730662	105	R>C		No	ClinGen gnomAD
rs779978159 CA718207	106	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA339252409 rs1458496368	106	Q>R		No	ClinGen TOPMed
rs1438098024 CA339252392	107	W>C		No	ClinGen gnomAD
CA19938509 rs199748491	108	V>A		No	ClinGen 1000Genomes
CA718206 rs758424316	108	V>F		No	ClinGen ExAC TOPMed gnomAD
CA339252388 rs758424316	108	V>I		No	ClinGen ExAC TOPMed gnomAD
CA718205 rs750300316	110	T>I		No	ClinGen ExAC gnomAD
CA339251922 rs1299429108	112	D>N		No	ClinGen TOPMed
rs768478609 CA718191	113	T>I		No	ClinGen ExAC TOPMed gnomAD
CA339251909 rs768478609	113	T>N		No	ClinGen ExAC TOPMed gnomAD
CA19933596 rs866886354	114	S>I		No	ClinGen Ensembl
rs1412180755 CA339251894	115	S>R		No	ClinGen TOPMed gnomAD
CA718188 rs780031389	117	N>H		No	ClinGen ExAC
rs1337899350 CA339251869	117	N>I		No	ClinGen TOPMed
TCGA novel	118	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA718187 rs758110434	118	T>I		No	ClinGen ExAC gnomAD
rs1188866853 CA339251851	119	V>E		No	ClinGen gnomAD
rs745842090 CA718186	119	V>M		No	ClinGen ExAC gnomAD
rs1282586099 CA339251845	120	V>I		No	ClinGen gnomAD
rs1241478711 CA339251819	122	P>L		No	ClinGen gnomAD
rs1008120997 CA19933581	122	P>S		No	ClinGen TOPMed
CA718184 rs756224339	124	T>I		No	ClinGen ExAC TOPMed gnomAD
rs977722946 CA19933578	125	Y>C		No	ClinGen TOPMed
rs1273541282 CA339251736	129	A>G		No	ClinGen gnomAD
rs1571607482 CA339251716	131	H>P		No	ClinGen Ensembl
CA718180 rs751758104	132	L>P		No	ClinGen ExAC
CA718181 rs755260671	132	L>V		No	ClinGen ExAC gnomAD
rs1392219187 CA339251697	133	R>K		No	ClinGen TOPMed
CA339251662 rs1571607441	136	Q>*		No	ClinGen Ensembl
rs986952483 CA19933353	137	N>S		No	ClinGen Ensembl
CA718168 rs778925354	138	K>R		No	ClinGen ExAC gnomAD
rs770834134 CA718167	140	S>G		No	ClinGen ExAC gnomAD
rs781289959 CA718165	142	V>G		No	ClinGen ExAC TOPMed gnomAD
CA718166 rs749219918	142	V>I		No	ClinGen ExAC gnomAD
rs556071176 CA718164	143	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1420687764 CA339251535	143	A>V		No	ClinGen gnomAD
rs751811246 CA718163	144	F>S		No	ClinGen ExAC gnomAD
CA339251504 rs1176389757	146	I>T		No	ClinGen gnomAD
CA339251491 rs1437815647	147	M>I		No	ClinGen gnomAD
TCGA novel	150	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA718162 rs758120826	151	D>N		No	ClinGen ExAC TOPMed gnomAD
CA718161 rs758802798	151	D>V		No	ClinGen ExAC gnomAD
CA19933340 rs911286483	152	M>I		No	ClinGen TOPMed
CA339251400 rs1394072256	156	T>I		No	ClinGen TOPMed
CA339251397 rs1217448969	157	T>A		No	ClinGen gnomAD
CA718159 rs765627839	157	T>I		No	ClinGen ExAC gnomAD
CA718158 rs752598145	158	H>R		No	ClinGen ExAC gnomAD
rs535763830 CA718156	159	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs760225361 CA718155	161	E>K		No	ClinGen ExAC TOPMed gnomAD
CA718154 rs775289224	162	V>M		No	ClinGen ExAC gnomAD
CA339251344 rs1454547834	163	I>V		No	ClinGen gnomAD
rs374603144 CA718153	164	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs759215567 CA718152	165	A>S		No	ClinGen ExAC TOPMed gnomAD
CA19933333 rs986856911	166	H>D		No	ClinGen TOPMed gnomAD
CA339251299 rs1267803483	167	M>I		No	ClinGen gnomAD
CA718151 rs370079410	167	M>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1424890593 CA339251307	167	M>L		No	ClinGen TOPMed
CA339251305 rs1424890593	167	M>V		No	ClinGen TOPMed
rs1194133985 CA339251289	168	V>E		No	ClinGen gnomAD
rs58894196 CA19933328	173	N>D		No	ClinGen Ensembl
rs749244686 CA718149	174	S>G		No	ClinGen ExAC gnomAD
CA339251248 rs1347777972	174	S>N		No	ClinGen gnomAD
CA339251250 rs749244686	174	S>R		No	ClinGen ExAC gnomAD
rs1486026460 CA339251237	175	Q>H		No	ClinGen TOPMed gnomAD
rs1284426941 CA339251240	175	Q>P		No	ClinGen TOPMed gnomAD
rs766191837 CA718131	181	A>T		No	ClinGen ExAC gnomAD
rs377253918 CA19932392	181	A>V		No	ClinGen ESP
rs773145803 CA718129	182	P>A		No	ClinGen ExAC gnomAD
CA718128 rs373117782	183	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1476981638 CA339251154	187	G>R		No	ClinGen gnomAD
rs1313325257 CA339251118	192	G>R		No	ClinGen gnomAD
CA19932382 rs1017479000	193	N>K		No	ClinGen Ensembl
rs748070130 CA718127	195	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1006823696 CA19932371	196	G>E		No	ClinGen Ensembl
rs775468537 CA718126	196	G>R		No	ClinGen ExAC gnomAD
rs1462077347 CA339251083	197	N>K		No	ClinGen gnomAD
CA718125 rs772167431	197	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1557462796 CA339251079	198	S>G		No	ClinGen Ensembl
CA339251078 rs1422340426	198	S>N		No	ClinGen gnomAD
CA718124 rs143220390	200	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA718123 rs143220390	200	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1476016273 CA339251057	201	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1275762533 CA339251051	202	A>P		No	ClinGen TOPMed
rs757703165 CA718122	202	A>V		No	ClinGen ExAC gnomAD
rs28904899 CA718121 VAR_023302	203	N>S		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA718120 rs778270017	204	G>D		No	ClinGen ExAC TOPMed gnomAD
rs753219520 CA718118	206	T>A		No	ClinGen ExAC gnomAD
CA718117 rs766986933	207	V>M		No	ClinGen ExAC gnomAD
CA339251010 rs1235204609	209	Q>P		No	ClinGen gnomAD
CA339250996 rs1235350021	211	Q>E		No	ClinGen TOPMed
CA718097 rs751138848	218	A>S		No	ClinGen ExAC gnomAD
rs779533846 CA718096	220	P>L		No	ClinGen ExAC gnomAD
TCGA novel	220	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339250915 rs1322275693	221	R>G		No	ClinGen gnomAD
CA339250911 rs1409510067	221	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA718093 rs765037324	228	Q>E		No	ClinGen ExAC gnomAD
CA718092 rs761625313	228	Q>H		No	ClinGen ExAC gnomAD
rs1419416341 CA339250853	229	D>E		No	ClinGen TOPMed gnomAD
rs1009900509 CA19932233	232	N>T		No	ClinGen TOPMed
rs747655908 CA19932227	233	Q>H		No	ClinGen Ensembl
rs371319377 CA718091	236	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs760520445 CA718090 CA718089	237	M>I		No	ClinGen ExAC
rs1455059474 CA339250800	237	M>K		No	ClinGen gnomAD
CA19932216 rs201582355	237	M>V		No	ClinGen 1000Genomes
CA718088 rs774640706	238	S>P		No	ClinGen ExAC gnomAD
rs1054090047 CA19932201	240	S>F		No	ClinGen TOPMed
CA339250782 rs1054090047	240	S>Y		No	ClinGen TOPMed
rs771103313 CA718087	242	I>V		No	ClinGen ExAC gnomAD
CA339250768 rs1168426964	243	K>Q		No	ClinGen TOPMed gnomAD
CA339250747 rs1359154141	244	Q>K		No	ClinGen gnomAD
rs986227010 CA19931421	245	A>P		No	ClinGen Ensembl
CA718062 rs768876425	252	E>G		No	ClinGen ExAC TOPMed gnomAD
CA718061 rs747532813	254	H>R		No	ClinGen ExAC gnomAD
rs1420353749 CA339250676	254	H>Y		No	ClinGen gnomAD
COSM907934 CA19931409 rs769494381	255	I>V	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	256	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs367687334 CA19931401	262	D>E		No	ClinGen Ensembl
CA718057 rs771571842	264	F>L		No	ClinGen ExAC gnomAD
rs1557461116 CA339250605	264	F>S		No	ClinGen Ensembl
rs550898082 CA718056	265	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA339250570 rs1439443744	269	A>G		No	ClinGen gnomAD

No associated diseases with P15927

1 regional properties for P15927

Type	Name	Position	InterPro Accession
domain	Replication protein A, C-terminal	166 - 262	IPR014892

Functions

		Description
EC Number
Subcellular Localization	Nucleus Nucleus, PML body	Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
chromosome, telomeric region	The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
DNA replication factor A complex	A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PML body	A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.

7 GO annotations of molecular function

Name	Definition
damaged DNA binding	Binding to damaged DNA.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
G-rich strand telomeric DNA binding	Binding to G-rich, single-stranded, telomere-associated DNA.
protein N-terminus binding	Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein phosphatase binding	Binding to a protein phosphatase.
single-stranded DNA binding	Binding to single-stranded DNA.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

10 GO annotations of biological process

Name	Definition
base-excision repair	In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
DNA replication	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
double-strand break repair via homologous recombination	The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
mismatch repair	A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
mitotic G1 DNA damage checkpoint signaling	A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.
nucleotide-excision repair	A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
protein localization to chromosome	Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.
regulation of DNA damage checkpoint	Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.
regulation of double-strand break repair via homologous recombination	Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
telomere maintenance	Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q13156	RPA4	Replication protein A 30 kDa subunit	Homo sapiens (Human)	PR
Q9ZQ19	RPA2A	Replication protein A 32 kDa subunit A	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6DJ48	stn1	CST complex subunit STN1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MWNSGFESYG	SSSYGGAGGY	TQSPGGFGSP	APSQAEKKSR	ARAQHIVPCT	ISQLLSATLV
70	80	90	100	110	120
DEVFRIGNVE	ISQVTIVGII	RHAEKAPTNI	VYKIDDMTAA	PMDVRQWVDT	DDTSSENTVV
130	140	150	160	170	180
PPETYVKVAG	HLRSFQNKKS	LVAFKIMPLE	DMNEFTTHIL	EVINAHMVLS	KANSQPSAGR
190	200	210	220	230	240
APISNPGMSE	AGNFGGNSFM	PANGLTVAQN	QVLNLIKACP	RPEGLNFQDL	KNQLKHMSVS
250	260
SIKQAVDFLS	NEGHIYSTVD	DDHFKSTDAE