Q63569

PR
Gene name
Psmc3 (Tbp1)
Protein name
26S proteasome regulatory subunit 6A
Names
26S proteasome AAA-ATPase subunit RPT5, Proteasome 26S subunit ATPase 3, Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA, Tat-binding protein 1, TBP-1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29677
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-220 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q63569

Entry ID Method Resolution Chain Position Source
6EPC EM 1230 A M 1-439 PDB
6EPD EM 1540 A M 1-439 PDB
6EPE EM 1280 A M 1-439 PDB
6EPF EM 1180 A M 1-439 PDB
AF-Q63569-F1 Predicted AlphaFoldDB

No variants for Q63569

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63569

No associated diseases with Q63569

5 regional properties for Q63569

Type Name Position InterPro Accession
domain AAA+ ATPase domain 219 - 358 IPR003593
domain ATPase, AAA-type, core 223 - 355 IPR003959
conserved_site ATPase, AAA-type, conserved site 326 - 344 IPR003960
domain Proteasomal ATPase OB C-terminal domain 90 - 165 IPR032501
domain AAA ATPase, AAA+ lid domain 378 - 419 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Colocalizes with TRIM5 in cytoplasmic bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
proteasome accessory complex A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
identical protein binding Binding to an identical protein or proteins.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

4 GO annotations of biological process

Name Definition
blastocyst development The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
modulation by host of viral transcription Any process in which a host organism modulates the frequency, rate or extent of viral transcription.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17980 PSMC3 26S proteasome regulatory subunit 6A Homo sapiens (Human) PR
O88685 Psmc3 26S proteasome regulatory subunit 6A Mus musculus (Mouse) PR
Q63347 Psmc2 26S proteasome regulatory subunit 7 Rattus norvegicus (Rat) PR
P62198 Psmc5 26S proteasome regulatory subunit 8 Rattus norvegicus (Rat) PR
P46465 TBP1 26S proteasome regulatory subunit 6A homolog Oryza sativa subsp japonica (Rice) PR
Q9SEI2 RPT5A 26S proteasome regulatory subunit 6A homolog A Arabidopsis thaliana (Mouse-ear cress) PR
P54776 TBP1 26S proteasome regulatory subunit 6A homolog Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MNLLPTPESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IVQRTRLLDS EIKIMKSEVL
70 80 90 100 110 120
RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD PNDQEEDGAN IDLDSQRKGK
130 140 150 160 170 180
CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL VGVNKDSYLI LETLPTEYDS RVKAMEVDER
190 200 210 220 230 240
PTEQYSDIGG LDKQIQELVE AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC
250 260 270 280 290 300
AAQTKATFLK LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK
310 320 330 340 350 360
AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR KIEFPMPNEE
370 380 390 400 410 420
ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC VEAGMIALRR GATELTHEDY
430
MEGILEVQAK KKANLQYYA