AiPD: Autoinhibited Protein Database

Gene name	Psmc3 (Tbp1)
Protein name	26S proteasome regulatory subunit 6A
Names	26S proteasome AAA-ATPase subunit RPT5, Proteasome 26S subunit ATPase 3, Tat-binding protein 1, TBP-1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:19182
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-223 (Predicted disordered autoinhibitory region) PR

1-223 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O88685-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388568589	6	L>P	No	EVA
rs13476633	9	T>A	No	EVA
rs3388570966	33	G>E	No	EVA
rs3391736007	101	D>V	No	EVA
rs3391736030	102	V>I	No	EVA
rs3413113891	108	E>A	No	EVA
rs13467195	113	N>D	No	EVA
rs3391880573	115	D>A	No	EVA
rs3388566890	147	K>R	No	EVA
rs3388572670	157	N>I	No	EVA
rs3388570939	160	S>F	No	EVA
rs3388571140	199	Q>H	No	EVA
rs3388570949	203	E>*	No	EVA
rs3388563232	228	M>I	No	EVA
rs3388573284	240	A>G	No	EVA
rs3391905492	299	F>C	No	EVA
rs3391747963	306	D>A	No	EVA
rs27402339	319	Q>R	No	EVA
rs3388564724	346	L>Q	No	EVA
rs3412977869	353	R>C	No	EVA
rs3388566516	355	I>F	No	EVA
rs3388564712	413	R>K	No	EVA
rs3388568703	422	D>E	No	EVA
rs3388568657	427	I>V	No	EVA
rs3388563211	439	Q>E	No	EVA

Type	Name	Position	InterPro Accession
domain	WHEP-TRS domain	3 - 60	IPR000738
domain	Anticodon-binding	410 - 500	IPR004154
domain	Aminoacyl-tRNA synthetase, class II	61 - 393	IPR006195
domain	Histidyl-anticodon-binding	408 - 499	IPR033656
domain	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain	61 - 394	IPR041715

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Colocalizes with TRIM5 in cytoplasmic bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
proteasome accessory complex	A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, base subcomplex	The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
identical protein binding	Binding to an identical protein or proteins.
proteasome-activating activity	Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

Name	Definition
blastocyst development	The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
modulation by host of viral transcription	Any process in which a host organism modulates the frequency, rate or extent of viral transcription.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P17980	PSMC3	26S proteasome regulatory subunit 6A	Homo sapiens (Human)	PR
P46471	Psmc2	26S proteasome regulatory subunit 7	Mus musculus (Mouse)	PR
P62196	Psmc5	26S proteasome regulatory subunit 8	Mus musculus (Mouse)	PR
Q63569	Psmc3	26S proteasome regulatory subunit 6A	Rattus norvegicus (Rat)	PR
P46465	TBP1	26S proteasome regulatory subunit 6A homolog	Oryza sativa subsp japonica (Rice)	PR
Q9SEI2	RPT5A	26S proteasome regulatory subunit 6A homolog A	Arabidopsis thaliana (Mouse-ear cress)	PR
P54776	TBP1	26S proteasome regulatory subunit 6A homolog	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	PR