Q62753

PR
Gene name
Stxbp2 (Unc18b)
Protein name
Syntaxin-binding protein 2
Names
Protein unc-18 homolog 2, Munc18-2, Unc18-2, Protein unc-18 homolog B, Unc-18B
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:81804
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

288-359 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q62753

Entry ID Method Resolution Chain Position Source
AF-Q62753-F1 Predicted AlphaFoldDB

No variants for Q62753

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q62753

No associated diseases with Q62753

No regional properties for Q62753

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q62753

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
azurophil granule Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
cytolytic granule A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynapse The part of a synapse that is part of the presynaptic cell.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
specific granule Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
tertiary granule A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.
zymogen granule membrane The lipid bilayer surrounding a zymogen granule.

3 GO annotations of molecular function

Name Definition
syntaxin binding Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
syntaxin-1 binding Binding to a syntaxin-1 SNAP receptor.
syntaxin-3 binding Binding to a syntaxin-3 SNAP receptor.

12 GO annotations of biological process

Name Definition
cellular response to interferon-gamma Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
leukocyte mediated cytotoxicity The directed killing of a target cell by a leukocyte.
neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
neutrophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
positive regulation of mast cell degranulation Any process that activates or increases the frequency, rate or extent of mast cell degranulation.
regulation of mast cell degranulation Any process that modulates the frequency, rate, or extent of mast cell degranulation.
response to acidic pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
synaptic vesicle exocytosis Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P30619 SEC1 Protein transport protein SEC1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q15833 STXBP2 Syntaxin-binding protein 2 Homo sapiens (Human) PR
O08599 Stxbp1 Syntaxin-binding protein 1 Mus musculus (Mouse) PR
Q64324 Stxbp2 Syntaxin-binding protein 2 Mus musculus (Mouse) PR
Q63616 Vps33b Vacuolar protein sorting-associated protein 33B Rattus norvegicus (Rat) PR
Q5VNU3 Os06g0135900 Probable protein transport Sec1b Oryza sativa subsp japonica (Rice) PR
Q9C5P7 SEC1A Protein transport Sec1a Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAPLGLKAVV VEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED
70 80 90 100 110 120
INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR
130 140 150 160 170 180
SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAGERGRQLD VLAQQIATLC
190 200 210 220 230 240
ATLQEYPSIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV
250 260 270 280 290 300
SPLLHELTFQ AMAYDLLHIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS
310 320 330 340 350 360
KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS
370 380 390 400 410 420
VEKLCGVEQD LAMGSDAEGE KIKDTMKLIV PVLLDASVPP YDKIRVLLLY ILLRNGVSEE
430 440 450 460 470 480
NLAKLIQHAN VQSYSNLIRN LEQLGGTVTN SAGSGTSSRL ERRERMEPTY QLSRWSPVIK
490 500 510 520 530 540
DVMEDVVEDR LDRKLWPFVS DPAPVSSSQA AVSSARFGHW HKNKAGIEAR AGPRLIVYIV
550 560 570 580 590
GGVAMSEMRA AYEVTRATEG KWEVLIGSSH ILTPTRFLDD LRTLDQKLED IALP