P30619
Gene name |
SEC1 (YDR164C, YD8358.18C) |
Protein name |
Protein transport protein SEC1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR164C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30619
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30619-F1 | Predicted | AlphaFoldDB |
11 variants for P30619
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-783729 | 162 | A>P | No | SGRP | |
| s04-783540 | 225 | I>L | No | SGRP | |
| s04-783406 | 269 | M>I | No | SGRP | |
| s04-783389 | 275 | A>V | No | SGRP | |
| s04-783282 | 311 | I>V | No | SGRP | |
| s04-783277 | 312 | D>E | No | SGRP | |
| s04-783038 | 392 | A>V | No | SGRP | |
| s04-782957 | 419 | A>V | No | SGRP | |
| s04-782676 | 513 | F>V | No | SGRP | |
| s04-782631 | 528 | P>S | No | SGRP | |
| s04-782142 | 691 | S>G | No | SGRP |
No associated diseases with P30619
No regional properties for P30619
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P30619 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cellular bud tip | The end of a cellular bud distal to the site of attachment to the mother cell. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| syntaxin binding | Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| positive regulation of vesicle fusion | Any process that activates or increases the frequency, rate or extent of vesicle fusion. |
| vesicle docking involved in exocytosis | The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q15833 | STXBP2 | Syntaxin-binding protein 2 | Homo sapiens (Human) | PR |
| Q64324 | Stxbp2 | Syntaxin-binding protein 2 | Mus musculus (Mouse) | PR |
| O08599 | Stxbp1 | Syntaxin-binding protein 1 | Mus musculus (Mouse) | PR |
| Q62753 | Stxbp2 | Syntaxin-binding protein 2 | Rattus norvegicus (Rat) | PR |
| Q5VNU3 | Os06g0135900 | Probable protein transport Sec1b | Oryza sativa subsp japonica (Rice) | PR |
| Q9C5P7 | SEC1A | Protein transport Sec1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDLIELQRN | YLIGVLNQIE | TKNNLKFLII | DKTVETILSY | LFLTPQELLN | NVTSVDLIDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PTRKGQSSIE | AIYILEPTKY | NINCIDADFM | VRPPKYRRCH | IRFLPGLTNP | IFQFFQSKRY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IAQNLESFKP | IELGFFVKES | QFFETLQMEH | SLQVFFNNNC | KALIPTNVRK | IVGSLVSLCV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ITGEYPIVRY | SVSNPVEEED | ARNGNAVVNA | NSLTRSIANA | FQIAIDTYAR | NNPDFPPQNT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERPRSILIIT | DRTLDPFAPI | LHDFSYQAMA | YDLVANVDTQ | KDIYHYSAEN | EAGEQEEKVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLVDLYDPDW | IDLKHQHIMD | ANEYIQGRIK | ELIAKNPLLV | DRSNVKNTTD | LLSVVAHLKD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FDEERRRLIL | HKTLVDECLG | ENAERKLADI | SAIEQNLSGF | GMDFSGEKIK | HIIDDLLPAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AMKEPTILDK | LRYIIAYALF | RGGIIELDFI | KLLNFIGVTH | EHENFQQYLK | IFRNYDLIDF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLIKDKPKDK | PFQKEWFHDT | LVNDPNIYHT | SRFVPAVGNI | LSKVIANPLL | LSEQYFPYLK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DKPIELLNEE | EFQAGLANTS | ANSSSSLRNP | RHKAAWTTKS | SNIKKNIPRQ | RFFYYVIGGI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SIPEIKAAYD | QSNLKNRDIF | IGSDEILTPT | KFLDEVERLQ | NPREFFKFKE | DQRQQVNPPD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FLLREMKPVA | QPVSHVHLKS | QDNSPKSGTS | SPKAAGSLKS | EPPEKEKKRS | KFSRFLKRKS |
| HHDK |