AiPD: Autoinhibited Protein Database

Gene name	Pcolce (Pcpe1)
Protein name	Procollagen C-endopeptidase enhancer 1
Names	Atriopeptidase, Enkephalinase, Neutral endopeptidase 24.11, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, P14, Procollagen COOH-terminal proteinase enhancer 1, PCPE-1, Procollagen C-proteinase enhancer 1, Type 1 procollagen C-proteinase enhancer protein, Type I procollagen COOH-terminal proteinase enhancer
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:18542
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

241-381 (Predicted disordered autoinhibitory region) PR

241-381 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q61398-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388797223	9	F>Y	No	EVA
rs243028762	26	T>N	No	EVA
rs3388797178	27	P>L	No	EVA
rs3388797810	41	T>I	No	EVA
rs3388771532	114	F>L	No	EVA
rs3388803599	156	Q>*	No	EVA
rs3388803599	156	Q>E	No	EVA
rs3396320416	156	Q>R	No	EVA
rs3388800121	234	F>I	No	EVA
rs3395573219	253	Q>*	No	EVA
rs3388802978	256	S>T	No	EVA
rs3410965161	259	S>G	No	EVA
rs3388771574	276	A>T	No	EVA
rs33127062	282	A>S	No	EVA
rs251640083	284	S>N	No	EVA
rs32281135	289	V>I	No	EVA
rs3388805240	306	K>N	No	EVA
rs3388783195	309	P>T	No	EVA
rs3388795718	343	K>E	No	EVA
rs3388797749	345	Y>*	No	EVA
rs3388791615	359	S>I	No	EVA
rs3388802982	377	L>I	No	EVA
rs3388803659	382	S>R	No	EVA
rs3388786702	402	S>Y	No	EVA
rs46498362	420	S>N	No	EVA
rs3388802779	460	C>*	No	EVA
rs236563394	467	A>V	No	EVA
rs218278498	468	A>V	No	EVA
rs3396433352	469	A>V	No	EVA

Type	Name	Position	InterPro Accession
domain	CUB domain	36 - 148	IPR000859-1
domain	CUB domain	158 - 272	IPR000859-2
domain	Netrin domain	341 - 460	IPR001134
domain	Netrin module, non-TIMP type	352 - 458	IPR018933
domain	Procollagen C-endopeptidase enhancer, NTR domain	334 - 460	IPR035814

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

Name	Definition
collagen binding	Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
heparin binding	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
peptidase activator activity	Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

Name	Definition
cellular response to leukemia inhibitory factor	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q15113	PCOLCE	Procollagen C-endopeptidase enhancer 1	Homo sapiens (Human)	PR
Q8BNJ6	Neto2	Neuropilin and tolloid-like protein 2	Mus musculus (Mouse)	PR
Q8R4W6	Pcolce2	Procollagen C-endopeptidase enhancer 2	Mus musculus (Mouse)	PR
O08628	Pcolce	Procollagen C-endopeptidase enhancer 1	Rattus norvegicus (Rat)	PR