AiPD: Autoinhibited Protein Database

Gene name	Pcolce2 (Pcpe2)
Protein name	Procollagen C-endopeptidase enhancer 2
Names	Procollagen COOH-terminal proteinase enhancer 2, PCPE-2, Procollagen C-proteinase enhancer 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:76477
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

107-181 (Predicted disordered autoinhibitory region) PR

107-181 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8R4W6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs248623520	4	A>T	No	EVA
rs259336839	18	R>Q	No	EVA
rs225579834	115	V>I	No	EVA
rs3389038895	156	R>C	No	EVA
rs246293854	163	T>S	No	EVA
rs3389031242	169	W>G	No	EVA
rs3400327013	171	D>H	No	EVA
rs3389067180	173	D>E	No	EVA
rs3400617177	174	Y>*	No	EVA
rs244917697	189	N>S	No	EVA
rs3389042982	214	V>L	No	EVA
rs3389031303	216	N>K	No	EVA
rs387095579	219	E>K	No	EVA
rs3389072798	225	R>S	No	EVA
rs3389067194	229	Y>F	No	EVA
rs3389052314	255	L>*	No	EVA
rs3389059659	261	I>F	No	EVA
rs3389031304	263	H>L	No	EVA
rs3389057684	270	K>R	No	EVA
rs215064913	276	T>A	No	EVA
rs36826250	303	M>T	No	EVA
rs3389065836	309	N>I	No	EVA
rs3399995282	380	Q>H	No	EVA

Type	Name	Position	InterPro Accession
domain	CUB domain	32 - 143	IPR000859-1
domain	CUB domain	153 - 267	IPR000859-2
domain	Netrin domain	296 - 414	IPR001134
domain	Netrin module, non-TIMP type	307 - 412	IPR018933
domain	Procollagen C-endopeptidase enhancer, NTR domain	291 - 414	IPR035814

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
collagen-containing extracellular matrix	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

Name	Definition
collagen binding	Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
heparin binding	Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
peptidase activator activity	Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

Name	Definition
cellular response to leukemia inhibitory factor	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UKZ9	PCOLCE2	Procollagen C-endopeptidase enhancer 2	Homo sapiens (Human)	PR
Q8BNJ6	Neto2	Neuropilin and tolloid-like protein 2	Mus musculus (Mouse)	PR
Q61398	Pcolce	Procollagen C-endopeptidase enhancer 1	Mus musculus (Mouse)	PR