AiPD: Autoinhibited Protein Database

Gene name	Neto2 (Btcl2)
Protein name	Neuropilin and tolloid-like protein 2
Names	Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74513
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

383-471 (Predicted disordered autoinhibitory region) PR

383-471 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BNJ6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs864276198	18	L>F	No	EVA
rs3388985206	20	V>S	No	EVA
rs3388998008	21	E>D	No	EVA
rs252172083	108	R>*	No	EVA
rs3413066238	137	M>V	No	EVA
rs3399450583	226	Y>*	No	EVA
rs3399370566	232	N>F	No	EVA
rs864299708	241	V>D	No	EVA
rs1135301254	279	G>V	No	EVA
rs3388998311	282	L>R	No	EVA
rs3388973897	286	R>K	No	EVA
rs3399380483	296	P>S	No	EVA
rs3388998255	303	F>L	No	EVA
rs3388979396	374	R>W	No	EVA
rs1133212998	384	F>V	No	EVA
rs1132402675	386	K>I	No	EVA
rs1133877963	387	T>I	No	EVA
rs3388998013	410	A>V	No	EVA
rs3399368794	422	Y>F	No	EVA
rs3388950664	426	R>Q	No	EVA
rs3389002298	446	S>R	No	EVA
rs3388950665	447	V>M	No	EVA
rs3389003138	449	Q>H	No	EVA

Type	Name	Position	InterPro Accession
domain	CUB domain	45 - 159	IPR000859-1
domain	CUB domain	177 - 292	IPR000859-2
repeat	Low-density lipoprotein (LDL) receptor class A repeat	296 - 333	IPR002172
conserved_site	Low-density lipoprotein (LDL) receptor class A, conserved site	309 - 331	IPR023415

		Description
EC Number
Subcellular Localization	[Isoform 1]: Cell membrane ; Single-pass type I membrane protein ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

Name	Definition
ionotropic glutamate receptor binding	Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.

Name	Definition
regulation of kainate selective glutamate receptor activity	Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8NC67	NETO2	Neuropilin and tolloid-like protein 2	Homo sapiens (Human)	PR
Q8R4W6	Pcolce2	Procollagen C-endopeptidase enhancer 2	Mus musculus (Mouse)	PR
Q61398	Pcolce	Procollagen C-endopeptidase enhancer 1	Mus musculus (Mouse)	PR