O08628
Gene name |
Pcolce (Pcpe1) |
Protein name |
Procollagen C-endopeptidase enhancer 1 |
Names |
Procollagen COOH-terminal proteinase enhancer 1, PCPE-1, Procollagen C-proteinase enhancer 1, Type 1 procollagen C-proteinase enhancer protein, Type I procollagen COOH-terminal proteinase enhancer |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29569 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08628
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08628-F1 | Predicted | AlphaFoldDB |
No variants for O08628
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O08628 | |||||
No associated diseases with O08628
5 regional properties for O08628
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CUB domain | 36 - 148 | IPR000859-1 |
| domain | CUB domain | 158 - 272 | IPR000859-2 |
| domain | Netrin domain | 341 - 460 | IPR001134 |
| domain | Netrin module, non-TIMP type | 352 - 458 | IPR018933 |
| domain | Procollagen C-endopeptidase enhancer, NTR domain | 334 - 460 | IPR035814 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| collagen binding | Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). |
| heparin binding | Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
| peptidase activator activity | Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to leukemia inhibitory factor | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLPAALTSLL | GPFLLAWVLP | LARGQTPNYT | RPVFLCGGDV | TGESGYVASE | GFPNLYPPNK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KCIWTITVPE | GQTVSLSFRV | FDMELHPSCR | YDALEVFAGS | GTSGQRLGRF | CGTFRPAPVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APGNQVTLRM | TTDEGTGGRG | FLLWYSGRAT | SGTEHQFCGG | RMEKAQGTLT | TPNWPESDYP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PGISCSWHII | APSNQVIMLT | FGKFDVEPDT | YCRYDSVSVF | NGAVSDDSKR | LGKFCGDKAP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPISSEGNEL | LVQFVSDLSV | TADGFSASYR | TLPRDAVEKE | SAPSPGEDAQ | HGPQSRSDPK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TGTGPKVKPP | SKPKVQPVEK | PEGSPATQAT | PVAPDAPSIT | CPKQYKRSGT | LQSNFCSSSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVTGTVKAMV | RGPGEGLTVT | VSLLGVYKTG | DLDLPSPASG | TSLKFYVPCK | QMPPMKKGAS |
| 430 | 440 | 450 | 460 | ||
| YLLMGQVEEN | RGPILPPESF | VVLYRPNQDQ | ILSNLSKRKC | PSQPRPDA |