Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61316
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61316-F1 | Predicted | AlphaFoldDB |
No variants for Q61316
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q61316 | |||||
No associated diseases with Q61316
3 regional properties for Q61316
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 200 - 213 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 338 - 352 | IPR018181-2 |
| domain | HSPA4, nucleotide-binding domain | 2 - 384 | IPR042052 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent protein folding chaperone | Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| chaperone-mediated protein complex assembly | The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. |
| negative regulation of cell death | Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. |
| negative regulation of DNA binding | Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of protein phosphorylation | Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. |
| positive regulation of protein binding | Any process that activates or increases the frequency, rate or extent of protein binding. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| protein insertion into mitochondrial outer membrane | The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32590 | SSE2 | Heat shock protein homolog SSE2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32589 | SSE1 | Heat shock protein homolog SSE1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| O95757 | HSPA4L | Heat shock 70 kDa protein 4L | Homo sapiens (Human) | PR |
| P48722 | Hspa4l | Heat shock 70 kDa protein 4L | Mus musculus (Mouse) | PR |
| Q9JKR6 | Hyou1 | Hypoxia up-regulated protein 1 | Mus musculus (Mouse) | PR |
| Q05036 | hsp-110 | Heat shock protein 110 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVVGIDLGF | QSCYVAVARA | GGIETIANEY | SDRCTPACVS | FGPKNRSIGA | AAKSQVISNA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KNTVQGFKRF | HGRAFSDPFV | EAEKSNLAYD | IVQLPTGLTG | IKVTYMEEER | NFTTEQVTAM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLSKLKETAE | SVLKKPVVDC | VVSVPSFYTD | AERRSVMDAT | QIAGLNCLRL | MNETTAVALA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YGIYKQDLPA | LEEKPRNVVF | VDMGHSAYQV | SVCAFNKGKL | KVLATAFDTT | LGGRKFDEVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VNHFCEEFGK | KYKLDIKSKI | RALLRLSQEC | EKLKKLMSAN | ASDLPLSIEC | FMNDIDVSGT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MNRGKFLEMC | DDLLARVEPP | LRSVLEQSKL | KKEDIYAVEI | VGGATRIPAV | KEKISKFFGK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELSTTLNADE | AVTRGCALQC | AILSPAFKVR | EFSITDVVPY | PISLRWNSPA | EEGLSDCEVF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PKNHAAPFSK | VLTFYRKEPF | TLEAYYSSPQ | DLPYPDPAIA | QFSVQKVTPQ | SDGSSSKVKV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KVRVNVHGIF | SVSSAALVEV | HKSEESEEPM | ETDQNAKEEE | KMQVDQEEPH | TEEQQQQPQT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PAENKAESEE | METSQAGSKD | KKTDQPPQAK | KAKVKTSTVD | LPIEHTLWQL | DREMLALYTE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NEGKMIMQDK | LEKERNDAKN | AVEEYVYEMR | DKLSGEYEKF | VSEDDRNTFT | LKLEDTENWL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YEDGEDQPKQ | VYVDKLAELK | SLGQPIKTRF | QESEERPKLF | EELGKQIQQY | MKVISSFKNK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EDQYEHLDAA | DVTKVEKSTN | EAMEWMNSKL | NLQNKQSLTV | DPVVKTKEIE | AKIKELTSIC |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SPIISKPKPK | VEPPKEEPKH | AEQNGPVDGQ | GDNPGSQAAE | HGADTAVPSD | GDKKLPEMDI |
| D |