Q05036

PR
Gene name
hsp-110
Protein name
Heat shock protein 110
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C30C11.4
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

476-601 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q05036

Entry ID Method Resolution Chain Position Source
AF-Q05036-F1 Predicted AlphaFoldDB

No variants for Q05036

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q05036

No associated diseases with Q05036

2 regional properties for Q05036

Type Name Position InterPro Accession
conserved_site Heat shock protein 70, conserved site 202 - 215 IPR018181-1
conserved_site Heat shock protein 70, conserved site 341 - 355 IPR018181-2

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
response to topologically incorrect protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32590 SSE2 Heat shock protein homolog SSE2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P32589 SSE1 Heat shock protein homolog SSE1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O95757 HSPA4L Heat shock 70 kDa protein 4L Homo sapiens (Human) PR
P48722 Hspa4l Heat shock 70 kDa protein 4L Mus musculus (Mouse) PR
Q61316 Hspa4 Heat shock 70 kDa protein 4 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSVLGFDIGN LNCYIGVARQ GGIEVITNDY SLHATPACVS FGPKDRSMGV AARQAVTTNI
70 80 90 100 110 120
KNTVINFKHL IGRKFSDPVA QRFIPFIPCK VVKLPNDDIG VQVSYLGEPH TFTPEQVLAA
130 140 150 160 170 180
LLTKLRTIVE SQLSDVKKVS DCVLAVPSYF TDVQRRAVLS AIQYAGLNSL RIVNETTAIA
190 200 210 220 230 240
LAYGIYKQDL PEEDAKSRNV VFLDIGHSST QASLVAFNRG KLQMVNTSYD LESGGIWFDA
250 260 270 280 290 300
LIREHFRKEF KTKYGIDAAT SPRPWLRLLD ECERVKKQMS ANQTPIPLNI ECFMEDKDVT
310 320 330 340 350 360
GKMQRQEFED LAAPIFNRIK QVLINLFADG VSIKPEEIDE IEIVGGSSRI PMIREIVKDL
370 380 390 400 410 420
FGKEPKTTMN QDEAVARGAA MQCAILSPTF RVREFAIKDT QPYRIRLSWN STGENGGEND
430 440 450 460 470 480
VFSPRDEVPF SKLVSLLRSG PFNVEAHYAQ PNVVPHNQVH IGSWKVNGAR PGADGGNQKV
490 500 510 520 530 540
KVKVRVNPDG IFTIASATMY EPRIVEEVPA EAMEVDGDAK TEAPAEPLEP VKKTKLVPVD
550 560 570 580 590 600
LEVIESIPVS YDVQKFHNLE LQMQESDARE KAKADAKNSL EEYVYEMRDK VSDQYAEFIT
610 620 630 640 650 660
PAAADEFRSV LTSTEDWLYD EGEDAERDVY EKRLSELKAV GTPVVERYRE SETRKPAFDS
670 680 690 700 710 720
FDQSIMRVRK AYEDYANGGP TYAHLDSKEM EKVINAIEDK KKWLDEARHK QETRSKTDAP
730 740 750 760 770
VVFTEEILQN KNVFENVVNP ILNKKKPAAP APPKKEEPQP AAGDQPQSQP GEMDVD