P32589

PR
Gene name
SSE1 (MSI3, YPL106C, LPG3C)
Protein name
Heat shock protein homolog SSE1
Names
Chaperone protein MSI3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL106C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

477-581 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P32589

Entry ID Method Resolution Chain Position Source
2QXL X-ray 241 A A/B 2-659 PDB
3C7N X-ray 312 A A 1-666 PDB
3D2E X-ray 235 A PDB
3D2F X-ray 230 A PDB
AF-P32589-F1 Predicted AlphaFoldDB

3 variants for P32589

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-351855 140 D>N No SGRP
s16-350651 541 G>A No SGRP
s16-350201 691 D>G No SGRP

No associated diseases with P32589

2 regional properties for P32589

Type Name Position InterPro Accession
conserved_site Heat shock protein 70, conserved site 201 - 214 IPR018181-1
conserved_site Heat shock protein 70, conserved site 338 - 352 IPR018181-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
polysome A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.

5 GO annotations of molecular function

Name Definition
adenyl-nucleotide exchange factor activity Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
peptide binding Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.

5 GO annotations of biological process

Name Definition
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
proteasomal ubiquitin-independent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32590 SSE2 Heat shock protein homolog SSE2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O95757 HSPA4L Heat shock 70 kDa protein 4L Homo sapiens (Human) PR
P48722 Hspa4l Heat shock 70 kDa protein 4L Mus musculus (Mouse) PR
Q61316 Hspa4 Heat shock 70 kDa protein 4 Mus musculus (Mouse) PR
Q05036 hsp-110 Heat shock protein 110 Caenorhabditis elegans PR
10 20 30 40 50 60
MSTPFGLDLG NNNSVLAVAR NRGIDIVVNE VSNRSTPSVV GFGPKNRYLG ETGKNKQTSN
70 80 90 100 110 120
IKNTVANLKR IIGLDYHHPD FEQESKHFTS KLVELDDKKT GAEVRFAGEK HVFSATQLAA
130 140 150 160 170 180
MFIDKVKDTV KQDTKANITD VCIAVPPWYT EEQRYNIADA ARIAGLNPVR IVNDVTAAGV
190 200 210 220 230 240
SYGIFKTDLP EGEEKPRIVA FVDIGHSSYT CSIMAFKKGQ LKVLGTACDK HFGGRDFDLA
250 260 270 280 290 300
ITEHFADEFK TKYKIDIREN PKAYNRILTA AEKLKKVLSA NTNAPFSVES VMNDVDVSSQ
310 320 330 340 350 360
LSREELEELV KPLLERVTEP VTKALAQAKL SAEEVDFVEI IGGTTRIPTL KQSISEAFGK
370 380 390 400 410 420
PLSTTLNQDE AIAKGAAFIC AIHSPTLRVR PFKFEDIHPY SVSYSWDKQV EDEDHMEVFP
430 440 450 460 470 480
AGSSFPSTKL ITLNRTGDFS MAASYTDITQ LPPNTPEQIA NWEITGVQLP EGQDSVPVKL
490 500 510 520 530 540
KLRCDPSGLH TIEEAYTIED IEVEEPIPLP EDAPEDAEQE FKKVTKTVKK DDLTIVAHTF
550 560 570 580 590 600
GLDAKKLNEL IEKENEMLAQ DKLVAETEDR KNTLEEYIYT LRGKLEEEYA PFASDAEKTK
610 620 630 640 650 660
LQGMLNKAEE WLYDEGFDSI KAKYIAKYEE LASLGNIIRG RYLAKEEEKK QAIRSKQEAS
670 680 690
QMAAMAEKLA AQRKAEAEKK EEKKDTEGDV DMD