AiPD: Autoinhibited Protein Database

Gene name	Hspa4l (Apg1, Hsp4l, Osp94)
Protein name	Heat shock 70 kDa protein 4L
Names	Heat shock 70-related protein APG-1, Osmotic stress protein 94
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:18415
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

504-630 (Predicted disordered autoinhibitory region) PR

504-630 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P48722-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388628431	98	S>N	No	EVA
rs250840994	99	T>A	No	EVA
rs245929754	225	T>A	No	EVA
rs3393032052	237	D>E	No	EVA
rs3388626239	254	I>T	No	EVA
rs213709478	260	S>P	No	EVA
rs3392568219	397	L>P	No	EVA
rs3392938233	405	R>K	No	EVA
rs3392746691	422	K>IWFIKG*	No	EVA
rs3388623884	429	S>T	No	EVA
rs3388628610	432	I>T	No	EVA
rs3388624219	547	E>K	No	EVA
rs3388629016	571	T>I	No	EVA
rs3388625700	581	D>E	No	EVA
rs3388628550	597	L>I	No	EVA
rs3388628555	607	M>T	No	EVA
rs3388626222	685	G>V	No	EVA
rs3388628634	686	Q>R	No	EVA
rs3388618274	690	M>K	No	EVA
rs3388626130	708	K>R	No	EVA
rs3388631041	754	A>G	No	EVA
rs3388623854	761	T>N	No	EVA
rs3388624257	780	N>S	No	EVA
rs3388623875	785	I>M	No	EVA
rs3388630969	788	K>*	No	EVA
rs3388628943	820	P>S	No	EVA
rs3388624237	826	S>N	No	EVA

Type	Name	Position	InterPro Accession
domain	Helicase, C-terminal	433 - 632	IPR001650
conserved_site	SEC-C motif	892 - 909	IPR004027
domain	SecA DEAD-like, N-terminal	6 - 398	IPR011115
domain	SecA Wing/Scaffold	615 - 826	IPR011116
domain	SecA, preprotein cross-linking domain	228 - 354	IPR011130
domain	Helicase superfamily 1/2, ATP-binding domain	89 - 247	IPR014001
domain	SecA motor DEAD	3 - 616	IPR014018
conserved_site	SecA conserved site	496 - 511	IPR020937
domain	SecA, C-terminal helicase domain	416 - 586	IPR044722

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	May translocate to the nucleus after heat shock
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent protein folding chaperone	Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.

Name	Definition
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
response to unfolded protein	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32590	SSE2	Heat shock protein homolog SSE2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P32589	SSE1	Heat shock protein homolog SSE1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
O95757	HSPA4L	Heat shock 70 kDa protein 4L	Homo sapiens (Human)	PR
Q9JKR6	Hyou1	Hypoxia up-regulated protein 1	Mus musculus (Mouse)	PR
Q61316	Hspa4	Heat shock 70 kDa protein 4	Mus musculus (Mouse)	PR
Q05036	hsp-110	Heat shock protein 110	Caenorhabditis elegans	PR