Q61081
PR
Gene name |
Cdc37 |
Protein name |
Hsp90 co-chaperone Cdc37 |
Names |
Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12539 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61081
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61081-F1 | Predicted | AlphaFoldDB |
10 variants for Q61081
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389029979 | 75 | E>K | No | EVA | |
| rs3389035174 | 81 | E>A | No | EVA | |
| rs3389020942 | 105 | D>N | No | EVA | |
| rs3389008240 | 113 | M>I | No | EVA | |
| rs3389027700 | 163 | F>S | No | EVA | |
| rs3389020894 | 313 | K>N | No | EVA | |
| rs3389002759 | 323 | S>G | No | EVA | |
| rs3389020915 | 343 | W>* | No | EVA | |
| rs3399989316 | 354 | E>G | No | EVA | |
| rs231304409 | 377 | V>I | No | EVA |
No associated diseases with Q61081
9 regional properties for Q61081
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin, Y-type LIR-motif | 843 - 902 | IPR000233 |
| domain | Cadherin-like | 160 - 267 | IPR002126-1 |
| domain | Cadherin-like | 267 - 393 | IPR002126-2 |
| domain | Cadherin-like | 383 - 497 | IPR002126-3 |
| domain | Cadherin-like | 498 - 605 | IPR002126-4 |
| domain | Cadherin-like | 604 - 710 | IPR002126-5 |
| domain | Cadherin prodomain | 31 - 123 | IPR014868 |
| conserved_site | Cadherin conserved site | 370 - 380 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 593 - 603 | IPR020894-2 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chaperone complex | A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| HSP90-CDC37 chaperone complex | A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| chaperone binding | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
| heat shock protein binding | Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. |
| Hsp90 protein binding | Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| mitogen-activated protein kinase kinase kinase binding | Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. |
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| protein kinase B binding | Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| scaffold protein binding | Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. |
| unfolded protein binding | Binding to an unfolded protein. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of mitophagy in response to mitochondrial depolarization | Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization. |
| post-transcriptional regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| regulation of interferon-gamma-mediated signaling pathway | Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway. |
| regulation of protein kinase activity | Any process that modulates the frequency, rate or extent of protein kinase activity. |
| regulation of type I interferon-mediated signaling pathway | Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P06101 | CDC37 | Hsp90 co-chaperone Cdc37 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5EAC6 | CDC37 | Hsp90 co-chaperone Cdc37 | Bos taurus (Bovine) | PR |
| O57476 | CDC37 | Hsp90 co-chaperone Cdc37 | Gallus gallus (Chicken) | PR |
| Q24276 | Cdc37 | Hsp90 co-chaperone Cdc37 | Drosophila melanogaster (Fruit fly) | PR |
| Q16543 | CDC37 | Hsp90 co-chaperone Cdc37 | Homo sapiens (Human) | PR |
| Q63692 | Cdc37 | Hsp90 co-chaperone Cdc37 | Rattus norvegicus (Rat) | PR |
| A7YY97 | cdc37l1 | Hsp90 co-chaperone Cdc37-like 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDYSVWDHI | EVSDDEDETH | PNIDTASLFR | WRHQARVERM | EQFQKEKEEL | DRGCRECKRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VAECQRKLKE | LEVAESDGQV | ELERLRAEAQ | QLRKEERSWE | QKLEDMRKKE | KNMPWNVDTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKDGFSKSMV | NTKPEKAEED | SEEAREQKHK | TFVEKYEKQI | KHFGMLHRWD | DSQKYLSDNV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HLVCEETANY | LVIWCIDLEV | EEKCALMEQV | AHQTMVMQFI | LELAKSLKVD | PRACFRQFFT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KIKTADHQYM | EGFKYELEAF | KERVRGRAKL | RIEKAMKEYE | EEERKKRLGP | GGLDPVEVYE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLPEELQKCF | DVKDVQMLQD | AISKMDPTDA | KYHMQRCIDS | GLWVPNSKSG | EAKEGEEAGP |
| 370 | |||||
| GDPLLEAVPK | AGNEKDVSA |