AiPD: Autoinhibited Protein Database

Q16543

Gene name	CDC37 (CDC37A)
Protein name	Hsp90 co-chaperone Cdc37
Names	Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11140
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-179 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-179 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

18 structures for Q16543

Entry ID	Method	Resolution	Chain	Position	Source
1US7	X-ray	230 A	B	127-378	PDB
2K5B	NMR	-	B	148-276	PDB
2N5X	NMR	-	A	288-378	PDB
2NCA	NMR	-	A	1-126	PDB
2W0G	X-ray	188 A	A	148-276	PDB
5FWK	EM	390 A	E	1-378	PDB
5FWL	EM	900 A	E	1-378	PDB
5FWM	EM	800 A	E	1-378	PDB
5FWP	EM	720 A	E	1-378	PDB
5HPE	X-ray	227 A	A	5-20	PDB
7Z37	EM	367 A	DP1	1-378	PDB
7Z38	EM	316 A	D	1-378	PDB
7ZR0	EM	340 A	C	1-378	PDB
7ZR5	EM	390 A	C	1-378	PDB
7ZR6	EM	420 A	C	1-378	PDB
8GAE	EM	330 A	C	1-378	PDB
8GFT	EM	380 A	C	1-378	PDB
AF-Q16543-F1	Predicted				AlphaFoldDB

271 variants for Q16543

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs932654084 CA305234828	4	Y>C		No	ClinGen Ensembl
rs1478733958 CA404034373	5	S>R		No	ClinGen gnomAD
CA9194365 rs527724634	9	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA404034328 rs1435689555	11	E>D		No	ClinGen gnomAD
TCGA novel	17	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9194361 rs754903057	25	T>M		No	ClinGen ExAC gnomAD
CA404034222 rs1369845591	26	A>G		No	ClinGen gnomAD
rs779953833 CA9194359	28	L>F		No	ClinGen ExAC gnomAD
rs1229289732 CA404033826	36	R>Q	Variant assessed as Somatic; 4.649e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA404033815 rs1599381182	37	V>G		No	ClinGen Ensembl
rs753985741 CA9194334	40	M>T		No	ClinGen ExAC gnomAD
rs1384769343 CA404033763	42	Q>R		No	ClinGen TOPMed gnomAD
CA9194333 rs764202607	43	F>L		No	ClinGen ExAC gnomAD
CA9194332 rs756168318	44	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1568354981	46	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA404033699 rs1431904640	47	K>E		No	ClinGen Ensembl
CA404033663 rs1390241752	49	E>D		No	ClinGen gnomAD
CA404033673 rs1429182336	49	E>K		No	ClinGen gnomAD
CA404033657 rs1599381154	50	L>R		No	ClinGen Ensembl
rs753257006 CA9194331	51	D>H		No	ClinGen ExAC TOPMed gnomAD
CA404033633 rs1460637682	52	R>K		No	ClinGen gnomAD
rs1599381144 CA404033619	53	G>A		No	ClinGen Ensembl
rs1172086595 CA404033625	53	G>S		No	ClinGen TOPMed
rs201298683 CA9194330	55	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1166738720 CA404033600	55	R>H		No	ClinGen gnomAD
CA9194328 rs2231483	56	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404033594 rs1418455681	56	E>K		No	ClinGen gnomAD
rs373591353 CA9194327	57	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA305233125 rs901271535	57	C>Y		No	ClinGen gnomAD
CA404033570 rs1568354949	58	K>Q		No	ClinGen Ensembl
rs1468261970 CA404033564	58	K>T		No	ClinGen gnomAD
rs1223982195 CA404033552	59	R>C		No	ClinGen gnomAD
rs1041504198 CA305233123	59	R>H		No	ClinGen Ensembl
CA9194325 rs776392494	60	K>N		No	ClinGen ExAC gnomAD
rs1009740161 CA305233122	62	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA404033510 rs1389653422	62	A>V		No	ClinGen TOPMed
rs892595447 CA305233120	63	E>A		No	ClinGen TOPMed
rs370285288 CA9194324	63	E>K		No	ClinGen ESP ExAC gnomAD
TCGA novel	64	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9194323 rs746513596	64	C>G		No	ClinGen ExAC gnomAD
rs1439516669 CA404033412	71	L>M		No	ClinGen gnomAD
rs1159792472 CA404033376	74	A>G		No	ClinGen gnomAD
rs775571491 CA9194322	74	A>T		No	ClinGen ExAC gnomAD
rs771845881 CA9194321	75	E>K		No	ClinGen ExAC TOPMed gnomAD
rs771845881 CA404033373	75	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs778530307 CA9194318	78	K>R		No	ClinGen ExAC gnomAD
rs1431614706 CA404033322	79	A>V		No	ClinGen gnomAD
TCGA novel	80	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305233119 rs1001482629	81	L>R		No	ClinGen Ensembl
rs770724683 CA9194317	83	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9194316 rs749556906	86	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	87	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs111718868 CA305233116	92	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs150997404 CA9194312	92	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404033226 rs150997404	92	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404033219 rs145251489	93	K>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145251489 CA9194311	93	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404033196 rs1275981403	95	E>K		No	ClinGen gnomAD
rs1309955264 CA404033181	96	R>G		No	ClinGen gnomAD
CA404033178 rs1302729807	96	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1450372022 CA404033145	98	W>C		No	ClinGen TOPMed
CA404033114 rs1387043273	100	Q>H		No	ClinGen gnomAD
rs1372142418 CA404033103	101	K>R		No	ClinGen gnomAD
rs766695587 CA9194309	102	L>R		No	ClinGen ExAC gnomAD
CA404033058 rs373540380	104	E>D		No	ClinGen ESP ExAC gnomAD
CA9194307 rs753612399	106	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1599381042 CA404033035	106	R>H		No	ClinGen Ensembl
rs1170697492 CA404033011	108	K>E		No	ClinGen TOPMed
COSM710219 CA404032975 rs1294120646	110	K>N	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs775088677 CA9194303	110	K>R		No	ClinGen ExAC gnomAD
CA9194302 rs772075527	111	S>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs759428807 CA9194301	111	S>R		No	ClinGen ExAC gnomAD
rs370734241 CA9194299 CA9194300	112	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	112	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1599381014 CA404032932	114	W>G		No	ClinGen Ensembl
rs1247226242 CA404032906	116	V>M		No	ClinGen gnomAD
rs777979639 CA9194297	118	T>M		No	ClinGen ExAC TOPMed gnomAD
rs998562132 CA305233109	121	K>R		No	ClinGen TOPMed
rs1226071443 CA404032803	124	F>S		No	ClinGen TOPMed
rs781093439 CA404032785	125	S>R		No	ClinGen ExAC gnomAD
CA404032775 rs1315741525	126	K>R		No	ClinGen gnomAD
CA9194222 rs577768027	128	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1568354611 CA404031925	132	K>Q		No	ClinGen Ensembl
rs778842852 CA9194220	134	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1472467098 CA404031872	136	T>K		No	ClinGen gnomAD
rs1472467098 COSM1158210 CA404031870	136	T>M	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
CA305232993 rs988144565	137	E>G		No	ClinGen Ensembl
rs757178328 CA9194219	142	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1212076972 CA404031783	143	V>E		No	ClinGen gnomAD
rs1212076972 CA404031779	143	V>G		No	ClinGen gnomAD
rs143295429 CA9194216	145	E>K		No	ClinGen ESP ExAC TOPMed
CA9194217 rs143295429	145	E>Q		No	ClinGen ESP ExAC TOPMed
CA9194214 rs760371359	146	Q>K		No	ClinGen ExAC gnomAD
CA305232986 rs1032402107	148	H>Y		No	ClinGen Ensembl
CA9194213 rs753030780	150	T>N		No	ClinGen ExAC TOPMed gnomAD
CA305232983 rs1023795239	155	Y>H		No	ClinGen TOPMed
CA305232981 rs749532522	156	E>G		No	ClinGen Ensembl
rs145359780 CA9194209	158	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA404031580 rs145359780	158	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1450765512 CA404031556	160	K>E		No	ClinGen gnomAD
rs748457230 CA9194206 CA9194205	162	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1187371522 CA404031450	164	M>I		No	ClinGen gnomAD
CA305232944 rs866354313	166	R>C		No	ClinGen Ensembl
CA9194185 rs745566999	166	R>H		No	ClinGen ExAC TOPMed gnomAD
rs773978075 CA9194184	167	R>C		No	ClinGen ExAC gnomAD
rs770538573 CA9194183	167	R>H		No	ClinGen ExAC TOPMed gnomAD
CA9194182 rs748675716	168	W>S		No	ClinGen ExAC gnomAD
rs777775938 CA9194181	169	D>V		No	ClinGen ExAC gnomAD
rs1226769488 CA404031310	173	K>Q		No	ClinGen TOPMed gnomAD
CA305232931 rs55826704	173	K>R		No	ClinGen TOPMed
rs1599380546 CA404031280	174	Y>D		No	ClinGen Ensembl
CA9194180 rs755960486	174	Y>S		No	ClinGen ExAC gnomAD
rs201914397 CA9194179	177	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA9194178 rs781175114	178	N>D		No	ClinGen ExAC gnomAD
CA305232904 COSM1200360 rs1025592298	178	N>S	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA9194177 rs754800877	179	V>I		No	ClinGen ExAC gnomAD
rs994076132 CA305232898	180	H>R		No	ClinGen TOPMed
rs750412756 CA9194173	184	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9194172 rs765803614	185	E>K		No	ClinGen ExAC TOPMed gnomAD
CA404031157 rs1195801419	191	V>I		No	ClinGen TOPMed
TCGA novel	195	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404031112 rs1490621051	197	L>V		No	ClinGen gnomAD
CA9194169 rs764498981	198	E>Q		No	ClinGen ExAC gnomAD
rs761019690 CA9194168	199	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	200	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9194167 rs375165732	201	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA404031069 rs1437036878	202	K>Q		No	ClinGen gnomAD
CA404031051 rs1394172905	204	A>S		No	ClinGen gnomAD
CA404031037 rs1599380419	206	M>T		No	ClinGen Ensembl
rs1377115855 CA404031032	207	E>K		No	ClinGen gnomAD
rs1377115855 CA404031031	207	E>Q		No	ClinGen gnomAD
CA404031027 rs1266960631	207	E>V		No	ClinGen TOPMed
CA9194139 rs768657748	213	T>A		No	ClinGen ExAC gnomAD
CA9194138 rs147547295	214	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs965254505 CA305232763	215	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1169909459 CA404030943	219	I>T		No	ClinGen TOPMed
rs1422559694 CA404030921	223	A>P		No	ClinGen gnomAD
rs1183667122 CA404030905	225	S>N		No	ClinGen gnomAD
rs1183667122 CA404030904	225	S>T		No	ClinGen gnomAD
rs746133397 CA9194135	228	V>M		No	ClinGen ExAC gnomAD
rs1599380386 CA404030879	229	D>A		No	ClinGen Ensembl
rs1442847515 CA404030882	229	D>N		No	ClinGen TOPMed
CA404030872 rs1265872636	230	P>S		No	ClinGen gnomAD
rs757330227 CA9194133	231	R>Q		No	ClinGen ExAC gnomAD
COSM1711807 CA9194134 rs779190160	231	R>W	Variant assessed as Somatic; 0.0 impact. skin breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs147241364 CA9194130	235	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9194131 rs147241364	235	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140745389 CA9194132	235	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA404030728 rs1453478669	242	K>N		No	ClinGen gnomAD
CA404030142 rs1599379675	243	T>P		No	ClinGen Ensembl
CA404030139 rs1475574319	243	T>R		No	ClinGen TOPMed gnomAD
CA9194109 rs751893796	244	A>D		No	ClinGen ExAC gnomAD
CA9194108 rs765006356	245	D>N		No	ClinGen ExAC gnomAD
COSM990557 CA404030122 rs1269283551	246	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs756931215 CA9194107	246	R>H		No	ClinGen ExAC gnomAD
CA9194106 rs753516808	247	Q>R		No	ClinGen ExAC gnomAD
rs760227229 CA9194104	249	M>T		No	ClinGen ExAC gnomAD
rs1274511350 CA404030083	251	G>V		No	ClinGen gnomAD
rs141900325 CA9194101	253	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9194099 rs773411962 CA9194097	254	D>E		No	ClinGen ExAC TOPMed gnomAD
CA404030064 rs1409808851	254	D>G		No	ClinGen gnomAD
CA305231870 rs573570654	254	D>N		No	ClinGen TOPMed gnomAD
rs1331380957 CA404030047	255	E>D		No	ClinGen gnomAD
CA404030044 rs1410052865	256	L>V		No	ClinGen gnomAD
CA9194096 rs769835901	262	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9194095 rs748196343	262	R>H		No	ClinGen ExAC gnomAD
CA9194092 rs370952004	264	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA404029946 rs755464378	264	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs780606412 CA9194091	266	R>C		No	ClinGen ExAC gnomAD
rs758820884 CA9194090	266	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1207349631 CA404029901	268	K>R		No	ClinGen gnomAD
rs763773157 CA9194088	270	R>C		No	ClinGen ExAC gnomAD
rs1438499333 CA404029880	270	R>L		No	ClinGen gnomAD
rs148106370 CA9194087	271	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9194085 rs767381772	272	E>K		No	ClinGen ExAC gnomAD
CA9194084 rs759555262	273	K>E		No	ClinGen ExAC TOPMed gnomAD
CA305231836 rs1008098745	273	K>R		No	ClinGen TOPMed
CA404029826 rs1284471072	275	M>V		No	ClinGen TOPMed gnomAD
rs774253316 CA9194083	277	E>A		No	ClinGen ExAC
TCGA novel	277	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1022101507 CA404029774	278	Y>*		No	ClinGen TOPMed gnomAD
rs373932777 CA9194082	279	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA9194081 rs762736154	280	E>A		No	ClinGen ExAC gnomAD
rs748199547 CA9194078	281	E>A		No	ClinGen ExAC TOPMed gnomAD
rs770001005 CA404029721	281	E>K		No	ClinGen ExAC gnomAD
CA9194079 rs770001005	281	E>Q		No	ClinGen ExAC gnomAD
CA404029698 rs1470790409	282	E>K		No	ClinGen gnomAD
rs143134175 CA9194076	283	R>C		No	ClinGen ESP ExAC
rs149499190 CA9194075	283	R>H		No	ClinGen ESP ExAC gnomAD
CA404029587 rs1171197814	286	R>Q		No	ClinGen TOPMed
rs369260677 CA9194074	286	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772569186 CA305231777	288	G>R		No	ClinGen ExAC gnomAD
CA9194072 rs772569186	288	G>S		No	ClinGen ExAC gnomAD
rs777309634 CA404029553	289	P>L		No	ClinGen ExAC gnomAD
rs777309634 CA9194070	289	P>R		No	ClinGen ExAC gnomAD
CA404029550 rs373270944	290	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9194069 rs373270944	290	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9194066 rs754474320	291	G>C		No	ClinGen ExAC gnomAD
rs1208290674 CA404029537	291	G>D		No	ClinGen gnomAD
CA9194067 rs754474320	291	G>S		No	ClinGen ExAC gnomAD
rs1345827324 CA404029480	294	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs145608201 CA404029464	295	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9194064 RCV000969719 rs145608201	295	V>I		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs750170274 CA9194062	296	E>K		No	ClinGen ExAC TOPMed gnomAD
CA404029405 rs1454131942	298	Y>C		No	ClinGen gnomAD
rs1802887 CA9194060	299	E>K		No	ClinGen ExAC gnomAD
CA9194058 rs768846872	300	S>F		No	ClinGen ExAC TOPMed gnomAD
rs757882714 CA9194027	308	C>Y		No	ClinGen ExAC gnomAD
rs757086543 CA9194025	310	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757086543 CA9194024	310	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs759991798 CA305231516	311	V>A		No	ClinGen TOPMed gnomAD
CA404029084 rs759991798	311	V>G		No	ClinGen TOPMed gnomAD
CA404029078 rs1484833208	312	K>E		No	ClinGen TOPMed
rs764442187 CA9194022	314	V>L		No	ClinGen ExAC TOPMed gnomAD
rs764442187 CA404029049	314	V>M		No	ClinGen ExAC TOPMed gnomAD
CA404029040 rs1226049015	315	Q>E		No	ClinGen TOPMed
CA9194021 rs756440557	315	Q>H		No	ClinGen ExAC gnomAD
CA9194019 rs767760630	316	M>K		No	ClinGen ExAC TOPMed gnomAD
rs752940863 CA9194020	316	M>L		No	ClinGen ExAC gnomAD
rs766742653 COSM474113 CA9194016	320	A>T	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA305231492 rs369699110	320	A>V		No	ClinGen ESP TOPMed gnomAD
CA305231475 rs146674730	322	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1175944561 CA404028971	322	S>T		No	ClinGen gnomAD
rs770114325 CA9194013	326	P>R		No	ClinGen ExAC gnomAD
rs1320956910 CA404028903	327	T>A		No	ClinGen gnomAD
CA9194011 rs775113295	327	T>N		No	ClinGen ExAC gnomAD
rs532403111	328	D>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA9193955 rs754320960	328	D>Y		No	ClinGen ExAC gnomAD
rs937318355 CA305230428	329	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA9193953 rs761093540	329	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1045760389 CA305230426	330	K>R		No	ClinGen TOPMed
CA9193952 rs751173951	335	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA404027506 rs1283025760	337	I>T		No	ClinGen gnomAD
CA404027474 rs1395599379	338	D>E		No	ClinGen Ensembl
CA9193950 rs762577907	339	S>C		No	ClinGen ExAC gnomAD
CA404027383 rs1408881550 COSM1480519	343	V>I	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1393647573 CA404027365	344	P>A		No	ClinGen gnomAD
rs918777258 CA404027332	345	N>K		No	ClinGen TOPMed
CA404027342 rs1462161237	345	N>Y		No	ClinGen gnomAD
rs1428412208 CA404027313	346	S>C		No	ClinGen gnomAD
rs1268094643 CA404027323	346	S>P		No	ClinGen TOPMed
rs768403952 CA9193945	347	K>Q		No	ClinGen ExAC gnomAD
CA9193944 rs565002023	348	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs775595344 CA9193943	349	S>N		No	ClinGen ExAC TOPMed gnomAD
CA404027235 rs746058388	350	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9193941 rs746058388	350	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1197836126 CA404027203	351	A>S		No	ClinGen gnomAD
rs1197836126 CA404027207	351	A>T		No	ClinGen gnomAD
rs910099011 CA305230349	353	E>K		No	ClinGen gnomAD
CA404027146 rs1568353237	354	G>E		No	ClinGen Ensembl
rs768705987 CA305230348	354	G>R		No	ClinGen TOPMed
rs757312172 CA9193939	356	E>G		No	ClinGen ExAC gnomAD
rs779012581 CA9193940	356	E>K		No	ClinGen ExAC gnomAD
CA9193937 rs543529571	358	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs749856611 CA9193938	358	G>R		No	ClinGen ExAC TOPMed gnomAD
rs756445709 CA9193936	359	P>L		No	ClinGen ExAC gnomAD
VAR_022220 rs280528 CA9193935	360	G>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA404027115 rs1340610298	360	G>R		No	ClinGen Ensembl
CA404027106 rs1599378575	361	D>A		No	ClinGen Ensembl
rs1391684586 CA404027110	361	D>N		No	ClinGen gnomAD
rs1214056374 CA404027055	366	A>V		No	ClinGen TOPMed
rs1241817340 CA404027042	368	P>A		No	ClinGen TOPMed
CA305230261 rs971573679	370	T>M		No	ClinGen TOPMed gnomAD
rs542850499 CA9193929	372	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404026973 rs1408595288	373	E>G		No	ClinGen TOPMed
TCGA novel	373	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764037048 CA9193928	374	K>R		No	ClinGen ExAC
CA9193927 rs200352692	375	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	376	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	376	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404026888 rs1599378529	379	V>C		No	ClinGen Ensembl

No associated diseases with Q16543

3 regional properties for Q16543

Type	Name	Position	InterPro Accession
domain	EF-hand domain	105 - 245	IPR002048
binding_site	EF-Hand 1, calcium-binding site	175 - 187	IPR018247-1
binding_site	EF-Hand 1, calcium-binding site	223 - 235	IPR018247-2

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chaperone complex	A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
HSP90-CDC37 chaperone complex	A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.

8 GO annotations of molecular function

Name	Definition
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
heat shock protein binding	Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.
Hsp90 protein binding	Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
kinase binding	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein kinase regulator activity	Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.
scaffold protein binding	Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
unfolded protein binding	Binding to an unfolded protein.

8 GO annotations of biological process

Name	Definition
positive regulation of mitophagy in response to mitochondrial depolarization	Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization.
post-transcriptional regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
protein targeting	The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
regulation of interferon-gamma-mediated signaling pathway	Any process that modulates the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.
regulation of type I interferon-mediated signaling pathway	Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P06101	CDC37	Hsp90 co-chaperone Cdc37	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q5EAC6	CDC37	Hsp90 co-chaperone Cdc37	Bos taurus (Bovine)	PR
O57476	CDC37	Hsp90 co-chaperone Cdc37	Gallus gallus (Chicken)	PR
Q24276	Cdc37	Hsp90 co-chaperone Cdc37	Drosophila melanogaster (Fruit fly)	PR
Q61081	Cdc37	Hsp90 co-chaperone Cdc37	Mus musculus (Mouse)	PR
Q63692	Cdc37	Hsp90 co-chaperone Cdc37	Rattus norvegicus (Rat)	PR
A7YY97	cdc37l1	Hsp90 co-chaperone Cdc37-like 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MVDYSVWDHI	EVSDDEDETH	PNIDTASLFR	WRHQARVERM	EQFQKEKEEL	DRGCRECKRK
70	80	90	100	110	120
VAECQRKLKE	LEVAEGGKAE	LERLQAEAQQ	LRKEERSWEQ	KLEEMRKKEK	SMPWNVDTLS
130	140	150	160	170	180
KDGFSKSMVN	TKPEKTEEDS	EEVREQKHKT	FVEKYEKQIK	HFGMLRRWDD	SQKYLSDNVH
190	200	210	220	230	240
LVCEETANYL	VIWCIDLEVE	EKCALMEQVA	HQTIVMQFIL	ELAKSLKVDP	RACFRQFFTK
250	260	270	280	290	300
IKTADRQYME	GFNDELEAFK	ERVRGRAKLR	IEKAMKEYEE	EERKKRLGPG	GLDPVEVYES
310	320	330	340	350	360
LPEELQKCFD	VKDVQMLQDA	ISKMDPTDAK	YHMQRCIDSG	LWVPNSKASE	AKEGEEAGPG
370
DPLLEAVPKT	GDEKDVSV