Q24276
Gene name |
Cdc37 (E(sev)3B, CG12019) |
Protein name |
Hsp90 co-chaperone Cdc37 |
Names |
Hsp90 chaperone protein kinase-targeting subunit, Protein enhancer of sevenless 3B |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG12019 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q24276
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q24276-F1 | Predicted | AlphaFoldDB |
No variants for Q24276
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q24276 | |||||
No associated diseases with Q24276
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chaperone binding | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
| heat shock protein binding | Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. |
| insulin receptor binding | Binding to an insulin receptor. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein tyrosine kinase activator activity | Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. |
| unfolded protein binding | Binding to an unfolded protein. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of insulin receptor signaling pathway | Any process that increases the frequency, rate or extent of insulin receptor signaling. |
| positive regulation of neuroblast proliferation | Any process that activates or increases the rate of neuroblast proliferation. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P06101 | CDC37 | Hsp90 co-chaperone Cdc37 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5EAC6 | CDC37 | Hsp90 co-chaperone Cdc37 | Bos taurus (Bovine) | PR |
| O57476 | CDC37 | Hsp90 co-chaperone Cdc37 | Gallus gallus (Chicken) | PR |
| Q16543 | CDC37 | Hsp90 co-chaperone Cdc37 | Homo sapiens (Human) | PR |
| Q61081 | Cdc37 | Hsp90 co-chaperone Cdc37 | Mus musculus (Mouse) | PR |
| Q63692 | Cdc37 | Hsp90 co-chaperone Cdc37 | Rattus norvegicus (Rat) | PR |
| A7YY97 | cdc37l1 | Hsp90 co-chaperone Cdc37-like 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDYSKWKNI | EISDDEDDTH | PNIDTPSLFR | WRHQARVERM | AEMDHEKDEL | KKKRQSYQAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LMDVKERISK | KDGDEEALKK | ELEKIEAEGK | ELDRIESEMI | KKEKKTPWNV | DTISKPGFEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TVINKKAGRK | PDENLSEEER | EQRMKQFVKE | NEKLCQQYGM | LRKYDDSKRF | LQEHLHLVGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETANYLVIWS | INLEMEEKHE | LMAHVAHQCI | CMQYILELAK | QLDVDPRACV | SSFFSKIQHC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HPEYRAQFDS | EIEGFKGRIQ | KRAQEKIQEA | IAQAEEEERK | ERLGPGGLDP | ADVFESLPDE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKACFESRDV | ELLQKTIAAM | PVDVAKLHMK | RCVDSGLWVP | NAADLEGDKK | EEDDSDDVAG |
| 370 | 380 | ||||
| GEEKTDDAKS | ESAAKEEPIY | TGVSTEDVD |