Q5ZIB9

PR
Gene name
PRMT7 (RCJMB04_28e13)
Protein name
Protein arginine N-methyltransferase 7
Names
Histone-arginine N-methyltransferase PRMT7, [Myelin basic protein]-arginine N-methyltransferase PRMT7
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:415620
EC number
2.1.1.321: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZIB9

Entry ID Method Resolution Chain Position Source
AF-Q5ZIB9-F1 Predicted AlphaFoldDB

No variants for Q5ZIB9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZIB9

No associated diseases with Q5ZIB9

3 regional properties for Q5ZIB9

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 134 - 145 IPR001412
domain DALR anticodon binding 463 - 578 IPR008909
domain Arginyl-tRNA synthetase, catalytic core domain 124 - 449 IPR035684

Functions

Description
EC Number 2.1.1.321 Methyltransferases
Subcellular Localization
  • Cytoplasm, cytosol
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
[myelin basic protein]-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine.
histone methyltransferase activity (H4-R3 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.
histone-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.
protein-arginine omega-N monomethyltransferase activity Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine
protein-arginine omega-N symmetric methyltransferase activity +Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.
S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.

7 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
DNA methylation involved in gamete generation The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
histone arginine methylation The modification of a histone by addition of a methyl group to an arginine residue.
histone methylation The modification of histones by addition of methyl groups.
peptidyl-arginine methylation The addition of a methyl group to an arginine residue in a protein.
regulation of gene expression by genomic imprinting An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles.
spliceosomal snRNP assembly The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQV6 PRMT7 Protein arginine N-methyltransferase 7 Bos taurus (Bovine) PR
Q9W1V1 Art7 Protein arginine N-methyltransferase 7 Drosophila melanogaster (Fruit fly) PR
Q6P2P2 PRMT9 Protein arginine N-methyltransferase 9 Homo sapiens (Human) PR
Q9NVM4 PRMT7 Protein arginine N-methyltransferase 7 Homo sapiens (Human) PR
Q3U3W5 Prmt9 Protein arginine N-methyltransferase 9 Mus musculus (Mouse) PR
Q922X9 Prmt7 Protein arginine N-methyltransferase 7 Mus musculus (Mouse) PR
Q5U4E8 Prmt7 Protein arginine N-methyltransferase 7 Rattus norvegicus (Rat) PR
A2AV36 prmt7 Protein arginine N-methyltransferase 7 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKTFCGRANP TTGSLEWVEE DEDYDYHQEI ARSRYADMLH DKDRNMKYYQ GIRAAVSRVK
70 80 90 100 110 120
GRGEKAIVLD IGTGTGLLSM MAASAGADFC YAVEVFKPMA NAAVKIVEKN GFGDKIKVIN
130 140 150 160 170 180
KHSTEVTVGP DGDMQCRANI LVTELFDTEL IGEGALPTYE HAHKYLVQEG CEAVPHRATV
190 200 210 220 230 240
YVQLVESKRM WSWNKLFPVH VEAEDGEKII VSPSEMENCP GVPSVCDIQL NQMPSSDFTI
250 260 270 280 290 300
LSDVVTMFSV DFSKPVRSAS TCYRAQLDPV KSGKAQIVLS WWDIDMDPSG TINCTMAPYW
310 320 330 340 350 360
VKPMSAFQWR DHWMQCVYFL PKEEQVLQGE KVHLTACRDE YSVWYTLQKA REEDESKADA
370 380 390 400 410 420
RVESPVCRCQ AHLLWNRPRF GELNDQNRTR QYIKSLMSVL RTDSVCLCIS DGSLLPVLAH
430 440 450 460 470 480
YLGAEQVFTL ENSAVSCSVM KKFFKANHLE DKIKIVEARP ELLTSSHLEE KKISVLVGEP
490 500 510 520 530 540
FFTTSLLPWH NLYFWYARTA VTEHLASDVT VLPQSAALHM MIVEFQDLWR IRSPCGTCEG
550 560 570 580 590 600
FDVQTMDDMI KNSLNFRESK EAEPHPLWEY PCKSLSNPQE VLLFDFRKTV PQHCLSTEGS
610 620 630 640 650 660
VNLLRKGKSH GAVLWMEYHL TADISVSTGL MQISNEKGNC EWNPHCKQAV YFFSSVIESE
670 680
TLADVPTAVT YAIKFDTKTG EIAMDFKLL