Q3U3W5

PR
Gene name
Prmt9 (Prmt10)
Protein name
Protein arginine N-methyltransferase 9
Names
Protein arginine N-methyltransferase 10
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:102182
EC number
2.1.1.320: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3U3W5

Entry ID Method Resolution Chain Position Source
AF-Q3U3W5-F1 Predicted AlphaFoldDB

39 variants for Q3U3W5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388997507 43 T>P No EVA
rs212886172 81 S>R No EVA
rs3388964066 88 G>A No EVA
rs3398382252 114 M>R No EVA
rs263455668 135 N>S No EVA
rs47905137 164 M>T No EVA
rs3388992408 285 E>D No EVA
rs51757131 285 E>G No EVA
rs3388990448 300 G>A No EVA
rs3388969529 310 C>* No EVA
rs46595499 321 A>V No EVA
rs259592065 332 N>S No EVA
rs232619586 345 T>I No EVA
rs3388990104 346 E>* No EVA
rs3388963986 358 S>N No EVA
rs3399283825 432 W>C No EVA
rs3399352873 432 W>S No EVA
rs3399268005 433 E>Q No EVA
rs49522096 483 G>S No EVA
rs3388986241 511 P>S No EVA
rs244721226 527 L>F No EVA
rs261470503 556 P>S No EVA
rs51911193 611 V>M No EVA
rs3412695441 707 Q>L No EVA
rs3388990254 708 T>A No EVA
rs3388990056 711 E>* No EVA
rs3388963985 715 V>I No EVA
rs3388963989 754 P>S No EVA
rs3388945477 759 R>G No EVA
rs3388986202 763 M>K No EVA
rs3388990110 783 R>Q No EVA
rs3388997492 786 A>D No EVA
rs3388980716 787 V>L No EVA
rs265703643 819 N>D No EVA
rs231667801 819 N>S No EVA
rs45636255 824 Q>H No EVA
rs3388993185 826 G>E No EVA
rs236923038 843 A>T No EVA
rs217487293 846 P>Q No EVA

No associated diseases with Q3U3W5

1 regional properties for Q3U3W5

Type Name Position InterPro Accession
repeat Tetratricopeptide repeat 101 - 134 IPR019734

Functions

Description
EC Number 2.1.1.320 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
protein-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
protein-arginine omega-N monomethyltransferase activity Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine
protein-arginine omega-N symmetric methyltransferase activity +Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.

2 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
peptidyl-arginine methylation The addition of a methyl group to an arginine residue in a protein.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQV6 PRMT7 Protein arginine N-methyltransferase 7 Bos taurus (Bovine) PR
Q5ZIB9 PRMT7 Protein arginine N-methyltransferase 7 Gallus gallus (Chicken) PR
Q9W1V1 Art7 Protein arginine N-methyltransferase 7 Drosophila melanogaster (Fruit fly) PR
Q9NVM4 PRMT7 Protein arginine N-methyltransferase 7 Homo sapiens (Human) PR
Q6P2P2 PRMT9 Protein arginine N-methyltransferase 9 Homo sapiens (Human) PR
Q9JIF0 Prmt1 Protein arginine N-methyltransferase 1 Mus musculus (Mouse) PR
Q922X9 Prmt7 Protein arginine N-methyltransferase 7 Mus musculus (Mouse) PR
Q5U4E8 Prmt7 Protein arginine N-methyltransferase 7 Rattus norvegicus (Rat) PR
A2AV36 prmt7 Protein arginine N-methyltransferase 7 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPNSRPRPRR GAGGGAGAAG RDRLVARSLQ SAEHCLGDQD FGTAYAHYLL VLSLAPELKD
70 80 90 100 110 120
DVKETFQYTL FKWAEELHAL SRIQDLLGCY EQALELFPDD EVICNSMGEH LFRMGFRDEA
130 140 150 160 170 180
AGYFHKAVKL NPDFNDAKEN FYRVANWLVE RWHFIMLNDT RRNMVYNAAI QKAVCLGSRT
190 200 210 220 230 240
VLDIGTGTGI LSMFAKKAGA QSVYACELSK TMYELACDVV AANKMENGIK LLHMKSLDIE
250 260 270 280 290 300
IPKHIPERLS LVVTETVDAG VFGEGIVESL IHAWEHLLLQ PKTKEENGNC GKYGKVIPAG
310 320 330 340 350 360
AVIFGMAVEC AEIRRHHRVG AKDIAGIHLP TNVKFQSPAY TSVDTEETVE PYTTEKMSGI
370 380 390 400 410 420
PGGYLPLTEC FQIMKVDFNN LQELKSLATK KPHSLNVPAI KEGVLDAIMV WFVLQLDDEY
430 440 450 460 470 480
SLSTSPSEET CWEQAVYPVQ ALEDYCIQPG DRVTMEASCH DCYLRIQGIS ILHLEHEMEV
490 500 510 520 530 540
MKGFTKSKDL LSLGNEAELC SALANLQTSR PEALEQTCML EPTEIALLNN IPYHEGFKTA
550 560 570 580 590 600
MRKVLSSLAP ELLWQPMDTH CQYMEMNSGS GQSDAAPSTA DPFYVLDVSE GFSLLPILAG
610 620 630 640 650 660
TLGHVKPYSS VEKDQHCIAL DLIAEANHFP KETLEFWLRH IEDEAAVLQR PKSDKLWSII
670 680 690 700 710 720
ILDVIEPSGL IQQELMEKAA ISRCLLQSGG KIFPQYVLMF GMLVESQTLV EESAVQGTEH
730 740 750 760 770 780
TLGLNIAPFI NQFQVPIRVC LDLSSLPCVP LSQPVELLRL DLMTPYLNTS NKEVKVRVCR
790 800 810 820 830 840
SGRVTAVPFW FHLCLDDEVR LDTSGEASHW KQAAVVLDNP IQVQAGEELV LSVEHHKSNV
SIAVKP