Q5XIL2

PR
Gene name
Pi4k2b
Protein name
Phosphatidylinositol 4-kinase type 2-beta
Names
Phosphatidylinositol 4-kinase type II-beta
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:305419
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5XIL2

Entry ID Method Resolution Chain Position Source
AF-Q5XIL2-F1 Predicted AlphaFoldDB

No variants for Q5XIL2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5XIL2

No associated diseases with Q5XIL2

1 regional properties for Q5XIL2

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 116 - 447 IPR000403

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
  • Golgi apparatus membrane ; Peripheral membrane protein
  • Endoplasmic reticulum membrane
  • Cell membrane
  • Early endosome membrane
  • Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1
  • Association with early endosomes has not been confirmed
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endosome A vacuole to which materials ingested by endocytosis are delivered.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

2 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

4 GO annotations of biological process

Name Definition
endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZIK0 PI4K2B Phosphatidylinositol 4-kinase type 2-beta Gallus gallus (Chicken) PR
Q8TCG2 PI4K2B Phosphatidylinositol 4-kinase type 2-beta Homo sapiens (Human) PR
Q9BTU6 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha Homo sapiens (Human) PR
Q2TBE6 Pi4k2a Phosphatidylinositol 4-kinase type 2-alpha Mus musculus (Mouse) PR
Q8CBQ5 Pi4k2b Phosphatidylinositol 4-kinase type 2-beta Mus musculus (Mouse) PR
Q99M64 Pi4k2a Phosphatidylinositol 4-kinase type 2-alpha Rattus norvegicus (Rat) PR
Q505I0 pi4k2a Phosphatidylinositol 4-kinase type 2-alpha Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q28G26 pi4k2b Phosphatidylinositol 4-kinase type 2-beta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6PE18 pi4k2a Phosphatidylinositol 4-kinase type 2-alpha Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPEPPRDIMA EACEATRPSE DEDEEREPLL PRVAWAQPRR GAPGSAVRLQ ADQGAAVLRE
70 80 90 100 110 120
PATEEPPVVS EDRSISASLS TELDRTRNAV SETNTFLEDP EFADVVLKAE QAIEIGVFPE
130 140 150 160 170 180
RISQGSSGSY FVKDSKRTII GVFKPKSEEP YGQLNPKWTK YVHKVCCPCC FGRGCLLPNQ
190 200 210 220 230 240
GYLSEAGAYL VDTKLQLGIV PKTKVVWLVS ETFNYSAIDR AKSRGKKYAL EKVPKVGRKF
250 260 270 280 290 300
HRIGLPPKIG SFQLFVKDYK EAEYWLRRFE AEPLPENIRK QFQSQFERLV ILDYIIRNTD
310 320 330 340 350 360
RGNDNWLVKY DEMKYAKKIE SEESNWIDDK QLLIRIAAID NGLAFPFKHP DEWRAYPFHW
370 380 390 400 410 420
AWLPQAKVPF SEETRNLILP FISDMNFVQD LCEDLYELFK TDKGFDRAAF ESQMSVMRGQ
430 440 450 460 470
ILNLTQALRD GKSPMQLAQM PCVIVECSKS GGQGRVVHLG SSFTQTVHCR KPFFSSW