Q2TBE6

PR
Gene name
Pi4k2a
Protein name
Phosphatidylinositol 4-kinase type 2-alpha
Names
Phosphatidylinositol 4-kinase type II-alpha
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:84095
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-136 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2TBE6

Entry ID Method Resolution Chain Position Source
AF-Q2TBE6-F1 Predicted AlphaFoldDB

8 variants for Q2TBE6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3408550229 179 F>S No EVA
rs3389542186 287 N>S No EVA
rs3389533310 357 D>H No EVA
rs3389507404 442 H>L No EVA
rs3389533292 448 P>S No EVA
rs3389544475 453 T>K No EVA
rs217323870 461 A>T No EVA
rs3389497319 462 S>R No EVA

No associated diseases with Q2TBE6

1 regional properties for Q2TBE6

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 124 - 453 IPR000403

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor
  • Membrane raft
  • Endosome
  • Cytoplasmic vesicle
  • Cell projection, dendrite
  • Presynaptic cell membrane
  • Synapse, synaptosome
  • Mitochondrion
  • Membrane ; Lipid-anchor
  • Cell membrane
  • Perikaryon
  • Cell projection, neuron projection
  • Found in subdomains of the plasma membrane termed non-caveolar membrane rafts
  • Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3-complexes-dependent manner (PubMed:21998198)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

22 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
BLOC-1 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
early endosome membrane The lipid bilayer surrounding an early endosome.
endosome A vacuole to which materials ingested by endocytosis are delivered.
exocytic vesicle A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
growing cell tip The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intrinsic component of membrane The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

4 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
AP-3 adaptor complex binding Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein-containing complex binding Binding to a macromolecular complex.

6 GO annotations of biological process

Name Definition
basophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil.
endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
phosphatidylinositol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZIK0 PI4K2B Phosphatidylinositol 4-kinase type 2-beta Gallus gallus (Chicken) PR
Q8TCG2 PI4K2B Phosphatidylinositol 4-kinase type 2-beta Homo sapiens (Human) PR
Q9BTU6 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha Homo sapiens (Human) PR
Q8CBQ5 Pi4k2b Phosphatidylinositol 4-kinase type 2-beta Mus musculus (Mouse) PR
Q5XIL2 Pi4k2b Phosphatidylinositol 4-kinase type 2-beta Rattus norvegicus (Rat) PR
Q99M64 Pi4k2a Phosphatidylinositol 4-kinase type 2-alpha Rattus norvegicus (Rat) PR
Q28G26 pi4k2b Phosphatidylinositol 4-kinase type 2-beta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q505I0 pi4k2a Phosphatidylinositol 4-kinase type 2-alpha Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6PE18 pi4k2a Phosphatidylinositol 4-kinase type 2-alpha Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDETSPLVSP ERAQPPEYTF PSGSGAHFPQ VPGGAVRVAA AAGSGPSPPC SPGHDRERQP
70 80 90 100 110 120
LLDRARGAAA QGQTHTVAVQ AQALAAQAAV AAHAVQTHRE RNDFPEDPEF EVVVRQAEVA
130 140 150 160 170 180
IECSIYPERI YQGSSGSYFV KDSQGRIVAV FKPKNEEPYG HLNPKWTKWL QKLCCPCCFG
190 200 210 220 230 240
RDCLVLNQGY LSEAGASLVD QKLELNIVPR TKVVYLASET FNYSAIDRVK SRGKRLALEK
250 260 270 280 290 300
VPKVGQRFNR IGLPPKVGSF QLFVEGYKDA DYWLRRFEAE PLPENTNRQL LLQFERLVVL
310 320 330 340 350 360
DYIIRNTDRG NDNWLIKYDC PMDNSSCRDT DWVMVREPVI KVAAIDNGLA FPLKHPDSWR
370 380 390 400 410 420
AYPFYWAWLP QAKVPFSQEI KDLILPKISD PNFIKDLEED LYELFKRDPG FDRGQFHKQI
430 440 450 460 470
AVMRGQILNL TQALKDNKSP LHLVQMPPVI VETARSHQRS ASESYTQSFQ SRKPFFSWW