Q5M729
PR
Gene name |
At1g54220 (F20D21.4) |
Protein name |
Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial |
Names |
Dihydrolipoamide S-acetyltransferase component 3 of pyruvate dehydrogenase complex, Pyruvate dehydrogenase complex component E2 3, PDC-E2 3, PDCE2 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G54220 |
EC number |
2.3.1.12: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5M729
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5M729-F1 | Predicted | AlphaFoldDB |
57 variants for Q5M729
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04959087 | 4 | A>T | No | 1000Genomes | |
| ENSVATH13566766 | 13 | K>* | No | 1000Genomes | |
| tmp_1_20249867_G_T | 19 | T>N | No | 1000Genomes | |
| tmp_1_20249862_G_C | 21 | L>V | No | 1000Genomes | |
| tmp_1_20249859_G_T | 22 | R>S | No | 1000Genomes | |
| ENSVATH14314139 | 25 | N>I | No | 1000Genomes | |
| ENSVATH01370003 | 26 | A>V | No | 1000Genomes | |
| ENSVATH04959069 | 32 | Y>F | No | 1000Genomes | |
| tmp_1_20249825_G_A | 33 | S>L | No | 1000Genomes | |
| tmp_1_20249672_T_A | 45 | T>S | No | 1000Genomes | |
| tmp_1_20249669_A_T | 46 | F>I | No | 1000Genomes | |
| ENSVATH04959064 | 48 | S>A | No | 1000Genomes | |
| ENSVATH04959063 | 50 | L>F | No | 1000Genomes | |
| ENSVATH04959062 | 60 | I>K | No | 1000Genomes | |
| tmp_1_20249304_T_G | 96 | M>L | No | 1000Genomes | |
| ENSVATH01369998 | 124 | T>I | No | 1000Genomes | |
| tmp_1_20248605_T_G | 156 | E>D | No | 1000Genomes | |
| ENSVATH04959058 | 156 | E>Q | No | 1000Genomes | |
| ENSVATH13566728 | 159 | C>Y | No | 1000Genomes | |
| tmp_1_20248344_C_T | 194 | G>E | No | 1000Genomes | |
| tmp_1_20248324_G_T | 201 | P>T | No | 1000Genomes | |
| ENSVATH04959053 | 216 | P>H | No | 1000Genomes | |
| ENSVATH13566727 | 218 | P>A | No | 1000Genomes | |
| tmp_1_20248192_C_T | 245 | D>N | No | 1000Genomes | |
| tmp_1_20248155_G_C | 257 | A>G | No | 1000Genomes | |
| tmp_1_20248152_T_A | 258 | E>V | No | 1000Genomes | |
| ENSVATH04959050 | 264 | L>V | No | 1000Genomes | |
| ENSVATH00097396 | 265 | S>A | No | 1000Genomes | |
| ENSVATH04959049 | 265 | S>L | No | 1000Genomes | |
| tmp_1_20248012_G_A | 275 | R>W | No | 1000Genomes | |
| ENSVATH04959048 | 276 | I>K | No | 1000Genomes | |
| ENSVATH04959047 | 279 | A>S | No | 1000Genomes | |
| tmp_1_20247991_C_T | 282 | D>N | No | 1000Genomes | |
| ENSVATH13566725 | 292 | A>V | No | 1000Genomes | |
| ENSVATH04959046 | 296 | P>L | No | 1000Genomes | |
| ENSVATH13566694 | 309 | Y>D | No | 1000Genomes | |
| ENSVATH04959045 | 318 | R>Q | No | 1000Genomes | |
| tmp_1_20247665_G_A | 322 | A>V | No | 1000Genomes | |
| ENSVATH14314072 | 334 | H>N | No | 1000Genomes | |
| ENSVATH00097393 | 340 | D>N | No | 1000Genomes | |
| ENSVATH00097392 | 344 | D>E | No | 1000Genomes | |
| ENSVATH04959043 | 351 | S>N | No | 1000Genomes | |
| ENSVATH00097388 | 393 | Y>N | No | 1000Genomes | |
| ENSVATH13566691 | 405 | A>T | No | 1000Genomes | |
| tmp_1_20247179_C_T | 411 | G>R | No | 1000Genomes | |
| ENSVATH13566690 | 415 | P>L | No | 1000Genomes | |
| ENSVATH13566689 | 437 | Q>K | No | 1000Genomes | |
| ENSVATH01369978 | 469 | C>Y | No | 1000Genomes | |
| ENSVATH04959037 | 496 | D>N | No | 1000Genomes | |
| ENSVATH01369974 | 501 | A>T | No | 1000Genomes | |
| tmp_1_20246647_C_T | 504 | M>I | No | 1000Genomes | |
| ENSVATH13566688 | 517 | G>V | No | 1000Genomes | |
| tmp_1_20246514_T_A | 522 | E>D | No | 1000Genomes | |
| ENSVATH04959035 | 525 | K>N | No | 1000Genomes | |
| ENSVATH14314070 | 527 | F>S | No | 1000Genomes | |
| ENSVATH01369968 | 535 | K>E | No | 1000Genomes | |
| tmp_1_20246466_T_G | 538 | L>F | No | 1000Genomes |
No associated diseases with Q5M729
4 regional properties for Q5M729
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Biotin/lipoyl attachment | 111 - 187 | IPR000089 |
| domain | 2-oxoacid dehydrogenase acyltransferase, catalytic domain | 309 - 539 | IPR001078 |
| binding_site | 2-oxo acid dehydrogenase, lipoyl-binding site | 136 - 165 | IPR003016 |
| domain | Peripheral subunit-binding domain | 247 - 285 | IPR004167 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.12 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| pyruvate dehydrogenase complex | Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetyltransferase activity | Catalysis of the transfer of an acetyl group to an acceptor molecule. |
| dihydrolipoyllysine-residue acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. |
| lipoic acid binding | Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glycolytic process | The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P11181 | DBT | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | Bos taurus (Bovine) | PR |
| P11182 | DBT | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | Homo sapiens (Human) | PR |
| P53395 | Dbt | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | Mus musculus (Mouse) | PR |
| Q23571 | dbt-1 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | Caenorhabditis elegans | PR |
| Q8RWN9 | At3g13930 | Dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M7Z1 | BCE2 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAYASRIINH | SKKLKDVSTL | LRRENAATIR | YYSNTNRAPL | NREDTFNSRL | GYPPLERISI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CSTSTLPVSI | IFSTTRSNLS | SAMGRPIFGK | EFSCLMQSAR | GFSSGSDLPP | HQEIGMPSLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PTMTEGNIAR | WLKKEGDKVA | PGEVLCEVET | DKATVEMECM | EEGYLAKIVK | AEGSKEIQVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVIAITVEDE | EDIGKFKDYT | PSSTADAAPT | KAEPTPAPPK | EEKVKQPSSP | PEPKASKPST |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPTGDRVFAS | PLARKLAEDN | NVPLSDIEGT | GPEGRIVKAD | IDEYLASSGK | GATAKPSKST |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DSKAPALDYV | DIPHSQIRKV | TASRLAFSKQ | TIPHYYLTVD | TCVDKLMALR | SQLNSFKEAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGKRISVNDL | VVKAAALALR | KVPQCNSSWT | DDYIRQFKNV | NINVAVQTEN | GLYVPVVKDA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DRKGLSTIGE | EVRLLAQKAK | ENSLKPEDYE | GGTFTVSNLG | GPFGIKQFCA | VVNPPQAAIL |
| 490 | 500 | 510 | 520 | 530 | |
| AVGSAEKRVV | PGNGPDQFNF | ASYMPVTLSC | DHRVVDGAIG | AEWLKAFKGY | IENPKSMLL |