Q50H33
Gene name |
Kctd8 |
Protein name |
BTB/POZ domain-containing protein KCTD8 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:243043 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q50H33
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q50H33-F1 | Predicted | AlphaFoldDB |
33 variants for Q50H33
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs222049771 | 29 | P>Q | No | EVA | |
| rs3388767427 | 47 | E>V | No | EVA | |
| rs3388767446 | 49 | N>I | No | EVA | |
| rs3388771390 | 70 | L>M | No | EVA | |
| rs3395603403 | 81 | G>A | No | EVA | |
| rs3395683956 | 81 | G>R | No | EVA | |
| rs3395333585 | 149 | K>Q | No | EVA | |
| rs3395809778 | 151 | T>A | No | EVA | |
| rs3395664362 | 152 | K>* | No | EVA | |
| rs3412883672 | 152 | K>R | No | EVA | |
| rs3395714757 | 157 | N>I | No | EVA | |
| rs3395809807 | 158 | D>V | No | EVA | |
| rs31508331 | 160 | C>G | No | EVA | |
| rs31508331 | 160 | C>R | No | EVA | |
| rs3395471295 | 162 | Q>* | No | EVA | |
| rs3395664404 | 162 | Q>L | No | EVA | |
| rs3395333605 | 171 | Q>H | No | EVA | |
| rs3395471486 | 175 | D>V | No | EVA | |
| rs3388764637 | 197 | G>DG* | No | EVA | |
| rs3388762420 | 200 | G>V | No | EVA | |
| rs3388762051 | 219 | S>C | No | EVA | |
| rs3388757787 | 220 | Y>* | No | EVA | |
| rs3388752837 | 220 | Y>N | No | EVA | |
| rs3388771362 | 223 | V>M | No | EVA | |
| rs3388767356 | 230 | A>T | No | EVA | |
| rs3388764878 | 234 | R>H | No | EVA | |
| rs3388767431 | 247 | A>T | No | EVA | |
| rs3388757756 | 285 | R>L | No | EVA | |
| rs3388761992 | 310 | D>H | No | EVA | |
| rs31501359 | 338 | D>N | No | EVA | |
| rs261668479 | 341 | R>H | No | EVA | |
| rs3388762361 | 347 | K>E | No | EVA | |
| rs251703132 | 408 | D>E | No | EVA |
No associated diseases with Q50H33
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| presynaptic membrane | A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| regulation of G protein-coupled receptor signaling pathway | Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q29RJ0 | KCTD18 | BTB/POZ domain-containing protein KCTD18 | Bos taurus (Bovine) | PR |
| A6H6X4 | KCTD4 | BTB/POZ domain-containing protein KCTD4 | Bos taurus (Bovine) | PR |
| Q9BQ13 | KCTD14 | BTB/POZ domain-containing protein KCTD14 | Homo sapiens (Human) | PR |
| Q8N5I3 | KCNRG | Potassium channel regulatory protein | Homo sapiens (Human) | PR |
| Q6PI47 | KCTD18 | BTB/POZ domain-containing protein KCTD18 | Homo sapiens (Human) | PR |
| Q96CX2 | KCTD12 | BTB/POZ domain-containing protein KCTD12 | Homo sapiens (Human) | PR |
| Q68DU8 | KCTD16 | BTB/POZ domain-containing protein KCTD16 | Homo sapiens (Human) | PR |
| Q6ZWB6 | KCTD8 | BTB/POZ domain-containing protein KCTD8 | Homo sapiens (Human) | PR |
| Q6WVG3 | Kctd12 | BTB/POZ domain-containing protein KCTD12 | Mus musculus (Mouse) | PR |
| Q5DTY9 | Kctd16 | BTB/POZ domain-containing protein KCTD16 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALKDTGSGG | STILPISEMV | SASSSPGAPL | AAAPGPCAPS | PFPEVVELNV | GGQVYVTKHS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLLSVPDSTL | ASMFSPSSPR | GGARRRGDLP | RDSRARFFID | RDGFLFRYVL | DYLRDKQLAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEHFPEKERL | LREAEFFQLT | DLVKLLSPKV | TKQNSLNDEC | CQSDLEDNVS | QGSSDALLLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GAAAGAPSGS | GAHGVSGVVG | GGSAPDKRSG | FLTLGYRGSY | TTVRDNQADA | KFRRVARIMV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CGRIALAKEV | FGDTLNESRD | PDRQPEKYTS | RFYLKFTYLE | QAFDRLSEAG | FHMVACNSSG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TAAFVNQYRD | DKIWSSYTEY | IFFRPPQKIV | SPKQEHEDRK | RDKVTDKGSE | SGTSCNELST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSCDSHSEAS | TPQDNPANTQ | QAAAHQPNTL | TLDRPSRKAP | VQWMPPPDKR | RNSELFQSLI |
| 430 | 440 | 450 | 460 | 470 | |
| SKSRETNLSK | KKVCEKLSVE | EEMKKCIQDF | KKIHIPDCFP | ERKRQWQSEL | LQKYGL |