Q4KM79

PR
Gene name
Dusp11 (Pir1)
Protein name
RNA/RNP complex-1-interacting phosphatase
Names
Dual specificity protein phosphatase 11, Phosphatase that interacts with RNA/RNP complex 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:297412
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4KM79

Entry ID Method Resolution Chain Position Source
AF-Q4KM79-F1 Predicted AlphaFoldDB

No variants for Q4KM79

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4KM79

No associated diseases with Q4KM79

4 regional properties for Q4KM79

Type Name Position InterPro Accession
domain Dual specificity phosphatase, catalytic domain 79 - 198 IPR000340
domain Tyrosine-specific protein phosphatases domain 126 - 195 IPR000387
active_site Protein-tyrosine phosphatase, active site 148 - 158 IPR016130
domain Dual specificity protein phosphatase domain 59 - 206 IPR020422

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nucleus speckle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

5 GO annotations of molecular function

Name Definition
phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
polynucleotide 5'-phosphatase activity Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate.
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
protein tyrosine/serine/threonine phosphatase activity Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
polynucleotide 5' dephosphorylation The process of removing one or more phosphate groups from the 5' end of a polynucleotide.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O75319 DUSP11 RNA/RNP complex-1-interacting phosphatase Homo sapiens (Human) PR
Q6NXK5 Dusp11 RNA/RNP complex-1-interacting phosphatase Mus musculus (Mouse) PR
Q4KM79 Dusp11 RNA/RNP complex-1-interacting phosphatase Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MNQWHYGRYS RGRDFTARAP PKKKGKNQIP ERWKDYLPVG QRMPGTRFIA FKVPLQKKFE
70 80 90 100 110 120
AKLMPEECFS PLDLFNKIQE QNEELGLIID LTYTQRYYKV EDLPKTISYI KILTVGHQVP
130 140 150 160 170 180
DSGTIFQFKS AVKEFLKRNK NNDKLIGVHC THGLNRTGYL ICRYLIDVEG MRPDDAIELF
190 200 210 220 230 240
NRCRGHCIER QNYIENLQKR RVRKNQNASA SRSGGLEDSA HLTEQVHTTN KPVNKGPKKS
250 260 270 280 290 300
RRGGHLESSQ HVQTQSSAYS FRKWSQNQSV YQRGFVPPPG PAGEDYSQRR FFWSMRPNGS
310 320
QATHHKKWIA ASYQRPFYPA SWEWNV