Q6NXK5
Gene name |
Dusp11 (Pir1) |
Protein name |
RNA/RNP complex-1-interacting phosphatase |
Names |
Dual specificity protein phosphatase 11, Phosphatase that interacts with RNA/RNP complex 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72102 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NXK5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NXK5-F1 | Predicted | AlphaFoldDB |
16 variants for Q6NXK5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs235858736 | 18 | A>V | No | EVA | |
| rs212357231 | 89 | I>M | No | EVA | |
| rs218030374 | 123 | N>K | No | EVA | |
| rs3388836193 | 146 | L>H | No | EVA | |
| rs3388836306 | 150 | H>L | No | EVA | |
| rs3388847962 | 157 | R>S | No | EVA | |
| rs3388838438 | 164 | R>G | No | EVA | |
| rs218288519 | 230 | N>T | No | EVA | |
| rs233140343 | 243 | R>H | No | EVA | |
| rs3413124493 | 246 | H>R | No | EVA | |
| rs3388838495 | 254 | Q>H | No | EVA | |
| rs3388842685 | 261 | P>Q | No | EVA | |
| rs3388827397 | 309 | Q>H | No | EVA | |
| rs212291301 | 316 | Y>D | No | EVA | |
| rs264450491 | 320 | N>H | No | EVA | |
| rs3388841565 | 321 | L>P | No | EVA |
No associated diseases with Q6NXK5
4 regional properties for Q6NXK5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dual specificity phosphatase, catalytic domain | 81 - 199 | IPR000340 |
| domain | Tyrosine-specific protein phosphatases domain | 127 - 196 | IPR000387 |
| active_site | Protein-tyrosine phosphatase, active site | 149 - 159 | IPR016130 |
| domain | Dual specificity protein phosphatase domain | 60 - 207 | IPR020422 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| intercellular bridge | A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
| polynucleotide 5'-phosphatase activity | Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. |
| protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| protein tyrosine/serine/threonine phosphatase activity | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| polynucleotide 5' dephosphorylation | The process of removing one or more phosphate groups from the 5' end of a polynucleotide. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| RNA metabolic process | The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNQHYGRHGR | GRGRDFAACA | PPKKKGRNHI | PERWKDYLPV | GQRMPGTRFI | AFKVPLQKKF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EAKLMPEECF | SPLDLFNKIQ | EQNEELGLII | DLTYTQRYYK | VEDLPETISY | IKIFTVGHQI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PDNDTIFQFK | CAVKEFLKKN | KNNDKLIGVH | CTHGLNRTGY | LICRYLIDVE | GMRPDDAIEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FNSCRGHCIE | RQNYIENLQK | RHVRKNRNVS | APRTDGLEDS | ADPTEQVYTN | NKPVKKKPRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NRRGGHLAPS | QHFQHQTQSS | PYSLRKWSQN | QSVYQRGLVP | PPGPAGEDYS | QRRFFWSARP |
| 310 | 320 | ||||
| NKWTAESYQR | PFYPYYWEWN | L |