O75319
Gene name |
DUSP11 (PIR1) |
Protein name |
RNA/RNP complex-1-interacting phosphatase |
Names |
Dual specificity protein phosphatase 11, Phosphatase that interacts with RNA/RNP complex 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:8446 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for O75319
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4JMJ | X-ray | 238 A | A | 28-208 | PDB |
| 4MBB | X-ray | 185 A | A | 29-207 | PDB |
| 4NYH | X-ray | 120 A | A/B/C | 29-205 | PDB |
| AF-O75319-F1 | Predicted | AlphaFoldDB |
No variants for O75319
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O75319 | |||||
No associated diseases with O75319
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| intercellular bridge | A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
| polynucleotide 5'-phosphatase activity | Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. |
| protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| protein tyrosine/serine/threonine phosphatase activity | Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRNSETLERG | VGGCRVFSCL | GSYPGIEGAG | LALLADLALG | GRLLGTHMSQ | WHHPRSGWGR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRDFSGRSSA | KKKGGNHIPE | RWKDYLPVGQ | RMPGTRFIAF | KVPLQKSFEK | KLAPEECFSP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDLFNKIREQ | NEELGLIIDL | TYTQRYYKPE | DLPETVPYLK | IFTVGHQVPD | DETIFKFKHA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VNGFLKENKD | NDKLIGVHCT | HGLNRTGYLI | CRYLIDVEGV | RPDDAIELFN | RCRGHCLERQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NYIEDLQNGP | IRKNWNSSVP | RSSDFEDSAH | LMQPVHNKPV | KQGPRYNLHQ | IQGHSAPRHF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HTQTQSLQQS | VRKFSENPHV | YQRHHLPPPG | PPGEDYSHRR | YSWNVKPNAS | RAAQDRRRWY |
| 370 | |||||
| PYNYSRLSYP | ACWEWTQ |