Q4A1L3

PR
Gene name
becn1
Protein name
Beclin-1
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:619357
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-134 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4A1L3

Entry ID Method Resolution Chain Position Source
AF-Q4A1L3-F1 Predicted AlphaFoldDB

No variants for Q4A1L3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4A1L3

No associated diseases with Q4A1L3

17 regional properties for Q4A1L3

Type Name Position InterPro Accession
domain Immunoglobulin subtype 2 43 - 108 IPR003598-1
domain Immunoglobulin subtype 2 136 - 202 IPR003598-2
domain Immunoglobulin subtype 2 238 - 301 IPR003598-3
domain Immunoglobulin subtype 2 330 - 393 IPR003598-4
domain Immunoglobulin subtype 37 - 120 IPR003599-1
domain Immunoglobulin subtype 130 - 217 IPR003599-2
domain Immunoglobulin subtype 232 - 315 IPR003599-3
domain Immunoglobulin subtype 323 - 404 IPR003599-4
domain Fibronectin type III 467 - 566 IPR003961-1
domain Fibronectin type III 601 - 698 IPR003961-2
domain Fibronectin type III 707 - 807 IPR003961-3
domain Immunoglobulin-like domain 31 - 118 IPR007110-1
domain Immunoglobulin-like domain 134 - 208 IPR007110-2
domain Immunoglobulin-like domain 229 - 299 IPR007110-3
domain Immunoglobulin-like domain 318 - 402 IPR007110-4
domain Immunoglobulin I-set 318 - 401 IPR013098
domain Immunoglobulin 132 - 203 IPR013151

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein
  • Endosome membrane ; Peripheral membrane protein
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Mitochondrion membrane ; Peripheral membrane protein
  • Cytoplasmic vesicle, autophagosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endosome membrane The lipid bilayer surrounding an endosome.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
phagophore assembly site Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
phosphatidylinositol 3-kinase complex, class III, type I A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.
phosphatidylinositol 3-kinase complex, class III, type II A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

12 GO annotations of biological process

Name Definition
autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cellular response to nitrogen starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
early endosome to late endosome transport The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
late endosome to vacuole transport The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.
positive regulation of autophagy Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q4A1L4 BECN1 Beclin-1 Bos taurus (Bovine) PR
Q5ZKS6 BECN1 Beclin-1 Gallus gallus (Chicken) PR
Q14457 BECN1 Beclin-1 Homo sapiens (Human) PR
A8MW95 BECN2 Beclin-2 Homo sapiens (Human) PR
O88597 Becn1 Beclin-1 Mus musculus (Mouse) PR
Q4A1L5 BECN1 Beclin-1 Sus scrofa (Pig) PR
Q91XJ1 Becn1 Beclin-1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
METSKSSTMQ VSFVCQRCSQ PLKLDTSFKI LDKVTMQELT APLVTTAAVK PGDIQEVDSN
70 80 90 100 110 120
IEETFAENRT DGVSRRLIPP ARMMSTESAT SFTLIGEASD GGTMENLSRR LKVTGDLFDI
130 140 150 160 170 180
MSGQTDVDHP LCEECTDTLL DQLDTQLNIT ENECQNYKRC LEILERMNED DKEKLEAKLK
190 200 210 220 230 240
ELAEDEDRLI QELEEVERNR ELVAKDIEKV REEAERLEQE EARYQKEYSE FKRQQLELDD
250 260 270 280 290 300
DLKSVENQMR YAQIQLDKLK KTNVFNATFH IWHSGQFGTI NNFRLGRLPS VPVEWNEINA
310 320 330 340 350 360
AWGQTVLLLH ALANKMGLQF QRYRLMPFGN HSYLESLTDK SKELPLYCSG GLRFFWDNKF
370 380 390 400 410 420
DHAMVAFLDC VQQFKEEVEK GDTGFCLPYR MDVEKGKIED TGGSGGSYSI KTQFNSEEQW
430 440
TKALKFMLTN LKWGLAWVSS QFYNK