AiPD: Autoinhibited Protein Database

A8MW95

Gene name	BECN2
Protein name	Beclin-2
Names	Beclin-1 autophagy-related pseudogene 1, Beclin-1-like protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:441925
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-97 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

2-97 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for A8MW95

Entry ID	Method	Resolution	Chain	Position	Source
5K7B	X-ray	230 A	A/B/C/D	158-250	PDB
5K9L	X-ray	252 A	A/B/C/D	158-250	PDB
8GT9	X-ray	200 A	A/B/C/D	157-248	PDB
8GU7	X-ray	260 A	C/D	157-248	PDB
AF-A8MW95-F1	Predicted				AlphaFoldDB

234 variants for A8MW95

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA40419282 rs1022965619	5	R>H		No	ClinGen TOPMed gnomAD
rs1409415141 CA424081228	8	C>Y		No	ClinGen TOPMed
rs774258195 CA40419287	10	R>H		No	ClinGen TOPMed gnomAD
CA424081253 rs1574223126	11	C>G		No	ClinGen Ensembl
CA40419291 rs537874120	12	H>Y		No	ClinGen 1000Genomes
rs969447773 CA40419294	13	Q>K		No	ClinGen TOPMed gnomAD
CA40419297 rs981186254	16	K>R		No	ClinGen TOPMed gnomAD
CA424081318 rs927944662	18	S>R		No	ClinGen TOPMed
rs879497481 CA40419306	22	E>*		No	ClinGen Ensembl
rs1180472108 CA424081355	23	S>P		No	ClinGen TOPMed
rs990320598 CA40419319	24	R>G		No	ClinGen TOPMed
CA40419323 rs960794859	24	R>S		No	ClinGen TOPMed
rs914210228 CA40419328	26	L>P		No	ClinGen TOPMed
rs1322601298 CA424081410	29	A>V		No	ClinGen TOPMed
CA40419334 rs554618230	32	P>L		No	ClinGen 1000Genomes
CA424081449 rs1220693675	34	S>T		No	ClinGen TOPMed
CA40419335 rs568331052	37	A>P		No	ClinGen 1000Genomes TOPMed gnomAD
rs568331052 CA40419336	37	A>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs568331052 CA424081476	37	A>T		No	ClinGen 1000Genomes TOPMed gnomAD
CA424081487 rs1333660347	38	E>K		No	ClinGen TOPMed
rs941196619 CA40419338	51	E>Q		No	ClinGen TOPMed
CA424081626 rs1574223159	53	T>P		No	ClinGen Ensembl
CA40419344 rs1038285969	55	A>T		No	ClinGen TOPMed
rs1416453161 CA424081647	55	A>V		No	ClinGen TOPMed
rs921189105 CA40419346	56	E>D		No	ClinGen gnomAD
CA424081659 rs1406440533	57	E>K		No	ClinGen TOPMed
rs1439845836 CA424081686	59	Q>H		No	ClinGen TOPMed
CA424081694 rs932547309	60	D>E		No	ClinGen TOPMed
CA424081700 rs1181424118	61	G>D		No	ClinGen TOPMed
rs1237624309 CA424081716	63	S>P		No	ClinGen TOPMed
CA424081730 rs1212009890	64	S>R		No	ClinGen TOPMed
CA424081735 rs1348641388	65	R>G		No	ClinGen gnomAD
CA40419362 rs890768184	66	S>Y		No	ClinGen Ensembl
CA40419371 rs527609990	71	G>D		No	ClinGen TOPMed
CA40419374 rs527609990	71	G>V		No	ClinGen TOPMed
CA40419377 rs998633463	74	S>F		No	ClinGen TOPMed gnomAD
rs533846102 CA40419386	77	H>R		No	ClinGen 1000Genomes
CA424081874 rs1243787267	78	A>D		No	ClinGen TOPMed
CA40419390 rs892676956	80	I>F		No	ClinGen Ensembl
rs1574223197 CA424081911	82	T>P		No	ClinGen Ensembl
CA424081938 rs1450694074	85	G>R		No	ClinGen TOPMed
rs1420825125 CA424081954	86	E>G		No	ClinGen TOPMed
rs1318322477 CA424081949	86	E>K		No	ClinGen TOPMed
CA424081972 rs1452086620	88	G>D		No	ClinGen gnomAD
rs553890054 CA40419403	89	A>T		No	ClinGen 1000Genomes
CA424082008 rs1212883935	92	M>V		No	ClinGen gnomAD
CA424082017 rs1161134572	93	L>F		No	ClinGen TOPMed
rs1443434758 CA424082026	94	S>G		No	ClinGen TOPMed
CA424082079 rs1574223214	99	A>E		No	ClinGen Ensembl
CA10862536 RCV000948243 rs61736147	103	I>M		No	ClinGen ClinVar 1000Genomes TOPMed dbSNP gnomAD
CA40419424 rs970044937	103	I>V		No	ClinGen TOPMed
rs762002404 CA40419438	106	I>L		No	ClinGen TOPMed
CA40419439 rs762002404	106	I>V		No	ClinGen TOPMed
rs1220380780 CA424082168	108	S>F		No	ClinGen TOPMed
rs971332450 CA40419441	110	Q>R		No	ClinGen TOPMed
CA40419444 rs960679517	113	V>A		No	ClinGen TOPMed
rs1031478610 CA424082218	114	D>A		No	ClinGen TOPMed
CA40419448 rs1031478610	114	D>G		No	ClinGen TOPMed
rs1269991851 CA424082225	115	H>Y		No	ClinGen TOPMed
CA40419461 rs865802770	116	P>S		No	ClinGen TOPMed
CA40419464 rs956075680	118	C>*		No	ClinGen TOPMed
CA40419472 rs914346484	118	C>G		No	ClinGen TOPMed
CA424082262 rs1423502615	119	E>D		No	ClinGen TOPMed
CA40419474 rs908626800	121	C>*		No	ClinGen TOPMed gnomAD
rs750583860 CA40419473	121	C>R		No	ClinGen Ensembl
CA424082284 rs1166549817	122	T>N		No	ClinGen TOPMed
CA40419475 rs546258943	123	D>N		No	ClinGen 1000Genomes TOPMed
CA424082327 rs1194158069	127	E>A		No	ClinGen TOPMed
rs565246581 CA40419476	127	E>Q		No	ClinGen TOPMed gnomAD
CA40419477 rs556275285	130	D>G		No	ClinGen 1000Genomes TOPMed gnomAD
CA424082360 rs1461348356	131	I>V		No	ClinGen gnomAD
CA40419480 rs187014284	134	A>T		No	ClinGen 1000Genomes TOPMed gnomAD
rs541793731 CA40419485	137	E>D		No	ClinGen 1000Genomes TOPMed
rs974317270 CA40419488	139	D>N		No	ClinGen TOPMed gnomAD
rs1308111029 CA424082440	140	S>N		No	ClinGen Ensembl
rs1305987120 CA424082468	143	Y>C		No	ClinGen TOPMed
rs561751223 CA40419489	144	Q>E		No	ClinGen 1000Genomes TOPMed gnomAD
CA424082484 rs1219653554	145	R>H		No	ClinGen TOPMed
rs1219653554 CA424082485	145	R>P		No	ClinGen TOPMed
rs929465977 CA40419493	148	E>Q		No	ClinGen TOPMed
CA40419512 rs527947465 CA40419498	150	G>R		No	ClinGen 1000Genomes TOPMed gnomAD
CA424082549 rs1574223272	153	A>T		No	ClinGen Ensembl
rs1051007902 CA40419521	155	S>R		No	ClinGen TOPMed
CA10795172 rs56335758 RCV000946579	158	E>K		No	ClinGen ClinVar 1000Genomes TOPMed dbSNP gnomAD
CA424082636 rs1193021327	163	R>G		No	ClinGen TOPMed
CA40419550 rs564698221	166	L>P		No	ClinGen 1000Genomes
CA40419571 rs755412110	167	R>P		No	ClinGen TOPMed gnomAD
rs755412110 CA424082671	167	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs955896440 CA40419568	167	R>W		No	ClinGen TOPMed gnomAD
CA424082700 rs1261680746	170	E>D		No	ClinGen TOPMed
rs1558168688 CA424082720	173	E>K		No	ClinGen Ensembl
CA424082745 rs1303992291	175	R>S		No	ClinGen TOPMed
rs1313331678 CA424082741	175	R>T		No	ClinGen TOPMed
rs1574223305 CA424082761	177	V>G		No	ClinGen Ensembl
CA40419575 rs953822151	184	D>N		No	ClinGen TOPMed
rs781674335 CA40419579	184	D>V		No	ClinGen TOPMed
rs752155053 CA40419586	185	R>S		No	ClinGen TOPMed gnomAD
CA424082847 rs1466323620	187	N>K		No	ClinGen TOPMed
rs1156808629 CA424082850	188	A>T		No	ClinGen TOPMed
rs755547837 CA40419597	191	A>E		No	ClinGen TOPMed gnomAD
rs755547837 CA424082881	191	A>V		No	ClinGen TOPMed gnomAD
CA424082884 rs1574223317	192	A>T		No	ClinGen Ensembl
rs1002895011 CA40419625	193	D>G		No	ClinGen TOPMed
rs1241489801 CA424082901	194	L>I		No	ClinGen TOPMed
rs929480534 CA40419638	194	L>P		No	ClinGen TOPMed
rs1483771809 CA424082913	195	Q>R		No	ClinGen TOPMed
rs377410460 CA40419645	197	A>S		No	ClinGen 1000Genomes TOPMed gnomAD
CA40419641 rs377410460	197	A>T		No	ClinGen 1000Genomes TOPMed gnomAD
CA424082974 rs1163412511	202	A>E		No	ClinGen gnomAD
rs1004179305 CA40419662	207	Q>*		No	ClinGen Ensembl
CA40419663 rs568935999	209	R>G		No	ClinGen 1000Genomes TOPMed gnomAD
rs1466525994 CA424083040	210	Q>K		No	ClinGen gnomAD
rs113658106 CA40419664	212	Y>C		No	ClinGen 1000Genomes TOPMed gnomAD
CA424083114 rs1574223335	215	Y>*		No	ClinGen Ensembl
rs907164740 CA40419665	216	S>N		No	ClinGen TOPMed
rs962788051 CA40419669	223	L>R		No	ClinGen TOPMed
CA40419673 rs1053034798	228	Q>H		No	ClinGen TOPMed gnomAD
rs1574223346 CA424083352	231	N>D		No	ClinGen Ensembl
CA424083371 rs1361019965	232	V>A		No	ClinGen TOPMed
CA40419679 rs777391854	232	V>L		No	ClinGen TOPMed gnomAD
rs777391854 CA40419677	232	V>M		No	ClinGen TOPMed gnomAD
rs1574223349 CA424083411	235	Q>K		No	ClinGen Ensembl
CA424083453 rs1159362722	238	Y>H		No	ClinGen TOPMed
CA40419691 rs548160937	240	R>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs891736875 CA40419704	241	V>G		No	ClinGen TOPMed gnomAD
CA424083517 rs1187070741	242	Q>H		No	ClinGen TOPMed
RCV000946580 rs3851304 CA10795173	243	R>M		No	ClinGen ClinVar 1000Genomes TOPMed dbSNP gnomAD
CA424083541 rs1258688528	244	D>E		No	ClinGen TOPMed
rs1488252820 CA424083592	248	E>G		No	ClinGen TOPMed
rs1574223362 CA424083652	253	T>P		No	ClinGen Ensembl
rs1356611528 CA424083681	255	T>K		No	ClinGen TOPMed
CA40419735 rs934529027	259	W>G		No	ClinGen Ensembl
CA40419739 rs988477241	260	V>A		No	ClinGen TOPMed gnomAD
CA40419737 rs374742846	260	V>M		No	ClinGen TOPMed gnomAD
rs1342098716 CA424083762	261	E>K		No	ClinGen TOPMed
CA424083800 rs1293186067	263	P>H		No	ClinGen TOPMed
rs914214553 CA40419744	264	L>W		No	ClinGen TOPMed
CA40419760 rs947135683	265	G>D		No	ClinGen Ensembl
rs905401257 CA40419766	266	V>A		No	ClinGen Ensembl
rs1421641008 CA424083857	267	I>S		No	ClinGen TOPMed
rs1421641008 CA424083855	267	I>T		No	ClinGen TOPMed
CA40419788 rs938187093	268	N>S		No	ClinGen TOPMed gnomAD
CA40419795 CA40419794 rs896745939	272	L>F		No	ClinGen TOPMed gnomAD
CA424083972 rs1477670855	274	R>H		No	ClinGen TOPMed
CA424083973 rs1477670855	274	R>L		No	ClinGen TOPMed
CA40419796 rs1004398758	275	L>P		No	ClinGen TOPMed
rs1478417702 CA424084002	276	P>A		No	ClinGen TOPMed gnomAD
rs61466879 CA40419797	279	R>H		No	ClinGen 1000Genomes TOPMed gnomAD
rs61466879 CA40419798	279	R>P		No	ClinGen 1000Genomes TOPMed gnomAD
CA424084055 rs1288506299	279	R>S		No	ClinGen TOPMed
rs898489671 CA40419799	283	N>K		No	ClinGen TOPMed
rs1318300260 CA424084190	287	T>S		No	ClinGen TOPMed
CA424084208 rs1467847860	288	A>D		No	ClinGen TOPMed gnomAD
CA424084210 rs1467847860	288	A>V		No	ClinGen TOPMed gnomAD
rs1403013513 CA424084237	290	G>R		No	ClinGen TOPMed
rs1322978892 CA424084282	292	A>E		No	ClinGen TOPMed
CA424084288 rs1387384924	293	A>S		No	ClinGen TOPMed
CA424084338 rs1574223419	298	T>P		No	ClinGen Ensembl
rs202157536 CA40419801	303	I>T		No	ClinGen 1000Genomes TOPMed gnomAD
CA424084446 rs1424777933	304	G>E		No	ClinGen TOPMed
CA424084465 rs938683709	305	L>P		No	ClinGen TOPMed gnomAD
rs938683709 CA40419815	305	L>Q		No	ClinGen TOPMed gnomAD
rs1053554354 CA40419819	306	Q>H		No	ClinGen TOPMed
CA40419822 rs891815891	308	Q>*		No	ClinGen TOPMed
rs1011880482 CA40419823	308	Q>R		No	ClinGen TOPMed gnomAD
rs986659220 CA40419825	311	R>G		No	ClinGen TOPMed gnomAD
CA424084561 rs1019417395	311	R>L		No	ClinGen TOPMed
CA40419826 rs1019417395	311	R>P		No	ClinGen TOPMed
rs1324475508 CA424084608	314	P>L		No	ClinGen gnomAD
CA424084631 rs1235139504	316	G>R		No	ClinGen gnomAD
TCGA novel	319	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs955956500 CA40419827	319	S>W		No	ClinGen TOPMed gnomAD
rs1287582168 CA424084766	325	T>A		No	ClinGen gnomAD
CA424084788 rs1221391563	326	D>G		No	ClinGen TOPMed
CA40419834 rs914268240	327	D>E		No	ClinGen gnomAD
rs1205076848 CA424084812	328	R>C		No	ClinGen gnomAD
CA40419837 rs947072880	328	R>H		No	ClinGen Ensembl
CA40419841 rs980294827	329	T>A		No	ClinGen TOPMed gnomAD
CA40419845 rs768827827	329	T>N		No	ClinGen Ensembl
CA424084822 rs980294827	329	T>P		No	ClinGen TOPMed gnomAD
CA40419855 rs149609148	332	P>L		No	ClinGen 1000Genomes TOPMed gnomAD
CA40419868 rs530221257	335	C>F		No	ClinGen Ensembl
CA424084939 rs572397311	337	G>R		No	ClinGen 1000Genomes TOPMed
rs572397311 CA40419873	337	G>W		No	ClinGen 1000Genomes TOPMed
rs775595863 CA40419874	338	G>R		No	ClinGen TOPMed
CA424085031 rs1160636987	343	L>I		No	ClinGen gnomAD
CA40419876 rs1056577028	344	N>S		No	ClinGen TOPMed gnomAD
CA40419879 rs1056577028	344	N>T		No	ClinGen TOPMed gnomAD
rs746987951 CA40419881	345	N>S		No	ClinGen TOPMed
CA40419899 rs541687956	350	A>G		No	ClinGen 1000Genomes
rs1453066810 CA424085137	350	A>P		No	ClinGen TOPMed gnomAD
rs1558168817 CA424085170	352	V>A		No	ClinGen Ensembl
CA424085184 rs1574223486	353	A>G		No	ClinGen Ensembl
CA424085213 rs1288288876	355	L>P		No	ClinGen gnomAD
rs1382682141 CA424085227	356	D>G		No	ClinGen TOPMed gnomAD
CA424085263 rs1441607013	358	M>I		No	ClinGen TOPMed
rs940307724 CA40419907	368	G>A		No	ClinGen TOPMed
rs1388354696 CA424085485	371	G>A		No	ClinGen gnomAD
CA40419910 rs970207686	373	S>C		No	ClinGen TOPMed
rs1574223505 CA424085535	374	L>Q		No	ClinGen Ensembl
CA424085532 rs1574223502	374	L>V		No	ClinGen Ensembl
rs1307190381 CA424085554	375	P>R		No	ClinGen TOPMed
rs1574223509 CA424085552	375	P>S		No	ClinGen Ensembl
CA40419920 rs769743968	376	Y>C		No	ClinGen TOPMed gnomAD
CA40419915 rs564659386	376	Y>N		No	ClinGen 1000Genomes TOPMed
rs1231654376 CA424085585	377	G>R		No	ClinGen gnomAD
CA40419926 rs938744096	381	E>V		No	ClinGen TOPMed
CA424312752 rs1416669684	383	G>C		No	ClinGen TOPMed
rs1237694153 CA424312781	386	E>G		No	ClinGen gnomAD
CA40896347 rs995512157	388	V>A		No	ClinGen Ensembl
CA424312813 rs1259542436	390	G>C		No	ClinGen TOPMed gnomAD
CA424312812 rs1259542436	390	G>S		No	ClinGen TOPMed gnomAD
rs988926924 CA40896348	391	R>*		No	ClinGen TOPMed
rs913191826 CA40896349	394	C>R		No	ClinGen TOPMed
CA424312856 rs1472382034	395	Y>H		No	ClinGen TOPMed
rs1050156390 CA40896350	399	T>I		No	ClinGen TOPMed
CA424312899 rs1489741077	400	H>D		No	ClinGen TOPMed gnomAD
CA424312931 rs1285167488	403	T>M		No	ClinGen TOPMed
rs1286697739 CA424312937	404	Q>*		No	ClinGen TOPMed
CA40896352 rs889878148	407	W>*		No	ClinGen TOPMed
CA40896351 rs889878148	407	W>C		No	ClinGen TOPMed
CA424312972 rs1378643680	408	T>K		No	ClinGen TOPMed
CA424312983 rs1558168855	409	K>R		No	ClinGen Ensembl
CA424312993 rs1214746889	410	A>V		No	ClinGen gnomAD
CA424313025 rs1206051703	414	M>V		No	ClinGen Ensembl
CA424313044 rs1285164000	416	I>V		No	ClinGen TOPMed
rs1450587327 CA424313070	419	K>Q		No	ClinGen TOPMed
rs184515322 CA40896353	420	W>*		No	ClinGen 1000Genomes TOPMed gnomAD
CA424313086 rs184515322	420	W>C		No	ClinGen 1000Genomes TOPMed gnomAD
rs1019469915 CA40896354	421	S>N		No	ClinGen TOPMed gnomAD
rs563874391 CA40896356	423	I>M		No	ClinGen 1000Genomes TOPMed
CA424313148 rs1381150442	428	R>G		No	ClinGen gnomAD
rs1418641796 CA424313153	428	R>S		No	ClinGen gnomAD
rs1010198913 CA40896357	429	Y>H		No	ClinGen TOPMed gnomAD

No associated diseases with A8MW95

2 regional properties for A8MW95

Type	Name	Position	InterPro Accession
domain	Atg6, BARA domain	246 - 426	IPR040455
domain	Atg6/beclin, coiled-coil domain	116 - 242	IPR041691

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
phagophore assembly site	Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
phosphatidylinositol 3-kinase complex, class III, type I	A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.
phosphatidylinositol 3-kinase complex, class III, type II	A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.

1 GO annotations of molecular function

Name	Definition
protein-containing complex binding	Binding to a macromolecular complex.

7 GO annotations of biological process

Name	Definition
autophagosome assembly	The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
cellular response to nitrogen starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.
endosome to lysosome transport	The directed movement of substances from endosomes to lysosomes.
G protein-coupled receptor catabolic process	The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor.
glucose homeostasis	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
late endosome to vacuole transport	The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZKS6	BECN1	Beclin-1	Gallus gallus (Chicken)	PR
Q14457	BECN1	Beclin-1	Homo sapiens (Human)	PR
Q4A1L3	becn1	Beclin-1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MSSIRFLCQR	CHQALKLSGS	SESRSLPAAP	APTSGQAEPG	DTREPGVTTR	EVTDAEEQQD
70	80	90	100	110	120
GASSRSPPGD	GSVSKGHANI	FTLLGELGAM	HMLSSIQKAA	GDIFDIVSGQ	AVVDHPLCEE
130	140	150	160	170	180
CTDSLLEQLD	IQLALTEADS	QNYQRCLETG	ELATSEDEAA	ALRAELRDLE	LEEARLVQEL
190	200	210	220	230	240
EDVDRNNARA	AADLQAAQAE	AAELDQQERQ	HYRDYSALKR	QQLELLDQLG	NVENQLQYAR
250	260	270	280	290	300
VQRDRLKEIN	CFTATFEIWV	EGPLGVINNF	RLGRLPTVRV	GWNEINTAWG	QAALLLLTLA
310	320	330	340	350	360
NTIGLQFQRY	RLIPCGNHSY	LKSLTDDRTE	LPLFCYGGQD	VFLNNKYDRA	MVAFLDCMQQ
370	380	390	400	410	420
FKEEAEKGEL	GLSLPYGIQV	ETGLMEDVGG	RGECYSIRTH	LNTQELWTKA	LKFMLINFKW
430
SLIWVASRYQ	K