AiPD: Autoinhibited Protein Database

Q14457

Gene name	BECN1 (GT197)
Protein name	Beclin-1
Names	Coiled-coil myosin-like BCL2-interacting protein, Protein GT197
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8678
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-140 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

15-140 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

19 structures for Q14457

Entry ID	Method	Resolution	Chain	Position	Source
2P1L	X-ray	250 A	B/D/F/H	107-135	PDB
2PON	NMR	-	A	106-128	PDB
3DVU	X-ray	250 A	C/D	105-130	PDB
4DDP	X-ray	155 A	A	241-450	PDB
4MI8	X-ray	210 A	C/D	107-130	PDB
5EFM	X-ray	195 A	A	141-171	PDB
5HHE	X-ray	146 A	A/D	175-265	PDB
5VAU	X-ray	175 A	E/F/G/H	105-130	PDB
5VAX	X-ray	200 A	E/F/G/H	105-130	PDB
5VAY	X-ray	180 A	E/F/G/H	105-130	PDB
6DCN	X-ray	244 A	C/D	105-130	PDB
6DCO	X-ray	220 A	C/D	105-130	PDB
6HOI	X-ray	114 A	F/G	93-102	PDB
6HOJ	X-ray	151 A	A/B/C	93-105	PDB
6HOK	X-ray	161 A	A	93-105	PDB
7BL1	EM	980 A	EEE	1-450	PDB
8SOR	EM	396 A	D	1-450	PDB
8SRQ	EM	620 A	Z	149-449	PDB
AF-Q14457-F1	Predicted				AlphaFoldDB

289 variants for Q14457

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs917605786 CA290803668	3	G>R		No	ClinGen Ensembl
CA8585504 rs768116884	6	T>K		No	ClinGen ExAC TOPMed gnomAD
CA399687788 rs1329783476	8	N>D		No	ClinGen TOPMed
rs774450039 CA8585502	9	N>S		No	ClinGen ExAC gnomAD
CA290803661 rs992453187	10	S>N		No	ClinGen Ensembl
rs1445837343 CA399687757	12	M>T		No	ClinGen TOPMed
rs1326640431 CA399687751	13	Q>E		No	ClinGen gnomAD
rs1326640431 CA399687752	13	Q>K		No	ClinGen gnomAD
CA8585501 rs768622632	14	V>E		No	ClinGen ExAC gnomAD
CA8585500 rs369307603	15	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA290803654 rs1025554370	17	V>M		No	ClinGen Ensembl
rs931035758 CA290803648	21	C>Y		No	ClinGen TOPMed
CA8585498 rs144217377	23	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399687651 rs1251878508	28	D>N		No	ClinGen gnomAD
rs777590770 CA8585496	29	T>R		No	ClinGen ExAC TOPMed gnomAD
CA290803637 rs975479453	30	S>N		No	ClinGen TOPMed
TCGA novel	32	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	34	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758279127 CA8585495	34	L>V		No	ClinGen ExAC gnomAD
rs748062728 CA8585494	36	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1215526319 CA399687591	37	V>I		No	ClinGen gnomAD
CA399687550 rs1288814183	43	T>P		No	ClinGen gnomAD
rs754436466 CA8585492	44	A>P		No	ClinGen ExAC gnomAD
rs768681704 CA8585475 COSM1750058	45	P>A	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs924343187 CA290802207	48	T>I		No	ClinGen gnomAD
rs1375392201 CA399687509	48	T>P		No	ClinGen TOPMed
CA399687483 rs1202752581	52	A>T		No	ClinGen TOPMed gnomAD
CA8585474 rs748726984	52	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8585468 rs562188841	59	E>D		No	ClinGen 1000Genomes
CA8585470 rs781641199	59	E>K		No	ClinGen ExAC gnomAD
CA8585467 rs757548540	60	E>K		No	ClinGen ExAC gnomAD
CA399687420 rs1321784340	61	E>G		No	ClinGen TOPMed
rs947007000 CA290802169	62	T>I		No	ClinGen TOPMed gnomAD
rs947007000 CA399687412	62	T>N		No	ClinGen TOPMed gnomAD
rs113316728 CA290802167	65	G>*		No	ClinGen gnomAD
CA8585465 rs764475983	65	G>E		No	ClinGen ExAC gnomAD
rs113316728 CA399687396	65	G>R		No	ClinGen gnomAD
CA399687393 rs1459005470	66	E>K		No	ClinGen TOPMed
rs374912252 CA8585452	68	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA290801759 rs199562786	69	F>L		No	ClinGen Ensembl
CA8585451 rs780986555	70	I>T		No	ClinGen ExAC TOPMed gnomAD
CA399687347 rs1259902790	71	E>K		No	ClinGen gnomAD
rs201863805 CA8585450	74	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8585449 rs200813134	74	R>H		No	ClinGen ExAC TOPMed gnomAD
rs199603878 CA8585448	75	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1300700992 CA399687319	75	Q>R		No	ClinGen gnomAD
CA399687302 rs1331331519	78	V>I		No	ClinGen gnomAD
rs753203583 CA8585446	79	S>F		No	ClinGen ExAC gnomAD
rs765239824 CA8585445 COSM1302861	80	R>C	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs759611322 CA8585444	80	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs759611322 CA399687288	80	R>L		No	ClinGen ExAC TOPMed gnomAD
CA290801740 rs768750881	81	R>K		No	ClinGen Ensembl
rs1276194878 CA399687255	85	P>L		No	ClinGen TOPMed
TCGA novel	85	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1276194878 CA399687256	85	P>R		No	ClinGen TOPMed
TCGA novel	86	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8585426 rs755530032	87	R>S		No	ClinGen ExAC gnomAD
rs1209397352 CA399687222	88	M>I		No	ClinGen gnomAD
CA290801525 rs930522329	89	M>V		No	ClinGen TOPMed
rs1442902913 CA399687202	91	T>I		No	ClinGen gnomAD
rs766512460 CA8585424	92	E>G		No	ClinGen ExAC
rs756226768 CA8585423	93	S>G		No	ClinGen ExAC gnomAD
CA290801519 rs974545042	94	A>T		No	ClinGen TOPMed
rs1278364162 CA399687185	94	A>V		No	ClinGen gnomAD
rs1278672887 CA399687164	97	F>V		No	ClinGen TOPMed
rs1293027246 CA399687154	98	T>I		No	ClinGen gnomAD
rs375740758 CA290801515	100	I>T		No	ClinGen ESP gnomAD
CA290801512 rs750853517	101	G>R		No	ClinGen Ensembl
TCGA novel	102	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_010384	103	A>V		No	UniProt
rs762836696 CA8585419	107	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1172310777 CA399687096	108	T>A		No	ClinGen gnomAD
TCGA novel	111	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1567672371 CA399687065	112	L>I		No	ClinGen Ensembl
rs765243264 CA8585417	112	L>R		No	ClinGen ExAC TOPMed gnomAD
rs80236238 CA290801508	113	S>R		No	ClinGen Ensembl
rs1474337210 CA399687053	114	R>*		No	ClinGen gnomAD
rs759566966 CA8585416	114	R>Q	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA290801506 rs912635174	115	R>K		No	ClinGen Ensembl
rs757512791 CA8585385	118	V>I		No	ClinGen ExAC gnomAD
CA399687006 rs1457782185	120	G>E		No	ClinGen TOPMed
CA399686970 rs1324544345	125	I>T		No	ClinGen TOPMed
rs778788915 CA8585382	125	I>V		No	ClinGen ExAC gnomAD
CA8585381 rs754804701	127	S>L		No	ClinGen ExAC TOPMed gnomAD
rs753640543 CA8585380	128	G>D		No	ClinGen ExAC TOPMed gnomAD
rs753640543 CA290801442	128	G>V		No	ClinGen ExAC TOPMed gnomAD
CA290801436 rs900405651	130	T>P		No	ClinGen Ensembl
CA8585379 rs766320356	131	D>N		No	ClinGen ExAC gnomAD
rs575137307 CA8585378	131	D>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1216331213 CA399686918	133	D>E		No	ClinGen gnomAD
CA8585377 rs749913352	136	L>F		No	ClinGen ExAC TOPMed gnomAD
CA399686901 rs749913352	136	L>V		No	ClinGen ExAC TOPMed gnomAD
CA399686862 rs1288698458	141	T>R		No	ClinGen gnomAD
CA290801432 rs371577008	144	L>F		No	ClinGen ExAC gnomAD
rs371577008 CA8585376	144	L>V		No	ClinGen ExAC gnomAD
CA8585375 rs377301305	148	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1302049991 CA399686805	150	T>A		No	ClinGen gnomAD
rs773982021 CA8585374	150	T>I		No	ClinGen ExAC gnomAD
CA8585373 rs768365766	152	L>V		No	ClinGen ExAC gnomAD
CA399686784 rs1597936497	153	N>S		No	ClinGen Ensembl
CA8585371 rs775765007	154	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1361123931 CA399686771	155	T>S		No	ClinGen TOPMed gnomAD
rs770286959 CA8585370	156	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1567672063 CA399686760	157	N>D		No	ClinGen Ensembl
CA290801412 rs1038870989	157	N>T		No	ClinGen TOPMed gnomAD
rs746392687 CA399686746	159	C>G		No	ClinGen ExAC TOPMed gnomAD
rs746392687 CA8585369	159	C>R		No	ClinGen ExAC TOPMed gnomAD
CA399686740 rs1376614831	160	Q>*		No	ClinGen gnomAD
rs781350341 CA8585368	163	K>T		No	ClinGen ExAC gnomAD
rs147205679 CA8585351	164	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8585350 rs367567072	164	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1135937 rs1423754164 CA399686688	165	C>F	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs143622099 CA8585349	166	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs760026747 CA8585348	168	I>L		No	ClinGen ExAC gnomAD
CA399686658 rs777260991	170	E>*		No	ClinGen ExAC TOPMed gnomAD
rs777260991 CA8585347	170	E>K		No	ClinGen ExAC TOPMed gnomAD
CA399686654 rs1170668763	170	E>V		No	ClinGen TOPMed
rs747051390 CA8585345 CA399686636	172	M>I		No	ClinGen ExAC TOPMed gnomAD
CA399686640 rs1199550012	172	M>T		No	ClinGen gnomAD
rs1242264281 CA399686632	173	N>S		No	ClinGen gnomAD
rs773451114 CA8585344	173	N>Y		No	ClinGen ExAC gnomAD
CA8585342 rs748326580	174	E>D		No	ClinGen ExAC gnomAD
CA399686593 rs1432436860	178	E>G		No	ClinGen gnomAD
CA8585341 rs779843943	182	M>I		No	ClinGen ExAC gnomAD
rs1465865643 CA399686547	184	L>P		No	ClinGen TOPMed gnomAD
rs1465865643 CA399686548	184	L>Q		No	ClinGen TOPMed gnomAD
rs1362892613 CA399686537	186	E>K		No	ClinGen gnomAD
CA290801335 rs913633076	191	E>D		No	ClinGen Ensembl
CA399686494 rs1369571411	192	E>G		No	ClinGen gnomAD
CA8585339 rs745730336	194	L>P		No	ClinGen ExAC gnomAD
CA8585338 rs781077880	197	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8585337 rs757232707	198	L>P		No	ClinGen ExAC gnomAD
TCGA novel	199	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8585335 rs780754769	201	V>M		No	ClinGen ExAC TOPMed gnomAD
CA399686430 rs1363794106	202	E>K		No	ClinGen TOPMed
rs758000771 CA8585334	205	R>C		No	ClinGen ExAC TOPMed gnomAD
rs141389235 CA8585332	205	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8585333 rs141389235	205	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8585331 rs759812640	207	I>T		No	ClinGen ExAC TOPMed gnomAD
CA399686391 rs1351420082	208	V>M		No	ClinGen TOPMed gnomAD
CA8585330 rs777173146	211	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1446788579 CA399686362	212	L>F		No	ClinGen TOPMed gnomAD
rs1446788579 CA399686363	212	L>V		No	ClinGen TOPMed gnomAD
rs201722661 CA8585328	213	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201722661 CA8585327	213	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1385853764 CA399686342	215	V>F		No	ClinGen gnomAD
rs1597935859 CA399686339	215	V>G		No	ClinGen Ensembl
TCGA novel	218	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772060984 CA8585326	219	A>T		No	ClinGen ExAC gnomAD
rs138937709 CA8585325	220	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399686311 rs138937709	220	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA290801277 rs376420962	223	D>G		No	ClinGen ESP gnomAD
rs1380163595 CA399686284	224	Q>E		No	ClinGen gnomAD
rs878915430 CA290801274	225	E>K		No	ClinGen Ensembl
rs1260797047 CA399686260	227	A>S		No	ClinGen gnomAD
CA399686257 rs1175194304	227	A>V		No	ClinGen TOPMed
CA399686255 rs1490494506	228	Q>*		No	ClinGen gnomAD
rs1399660521 CA399686252	228	Q>R		No	ClinGen TOPMed
CA8585300 rs770725412	230	Q>R		No	ClinGen ExAC gnomAD
rs972136460 CA290800680	231	R>K		No	ClinGen TOPMed gnomAD
TCGA novel	232	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399685637 rs1284762791	232	E>K		No	ClinGen gnomAD
CA399685620 rs1340354386	233	Y>N		No	ClinGen gnomAD
CA8585299 rs746860359	234	S>G		No	ClinGen ExAC gnomAD
rs879030764 CA290800676	235	E>D		No	ClinGen Ensembl
TCGA novel	238	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs995636976 CA290800673	238	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA8585298 rs777562790	239	Q>P		No	ClinGen ExAC gnomAD
rs1333592968 CA399685493	240	Q>H		No	ClinGen gnomAD
rs942107521 CA290800669	243	L>P		No	ClinGen Ensembl
rs772083921 CA8585297	244	D>N		No	ClinGen ExAC gnomAD
CA399685409 rs1225679982	245	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA8585296 rs148197780	248	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA399685353 rs1567670433	249	S>I		No	ClinGen Ensembl
CA399685348 rs1168859530	249	S>R		No	ClinGen gnomAD
rs909330651 CA290800663	254	M>T		No	ClinGen Ensembl
CA8585294 rs143018406	255	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8585295 rs143018406	255	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs371551932 CA8585293	255	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA399685264 rs143018406	255	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1007136248 CA290800654	256	Y>H		No	ClinGen TOPMed gnomAD
CA290800649 rs34128114	258	Q>H		No	ClinGen TOPMed
CA399685245 rs1344038417	258	Q>P		No	ClinGen Ensembl
rs1030558715 CA290800646	259	T>M		No	ClinGen TOPMed gnomAD
CA399685218 rs1192460073	262	D>E		No	ClinGen TOPMed
rs1051729710 CA290800641	262	D>H		No	ClinGen TOPMed gnomAD
CA8585290 rs750841748	268	N>S		No	ClinGen ExAC TOPMed gnomAD
rs370523548 CA290800636	273	T>A		No	ClinGen Ensembl
CA399685074 rs1367447764	281	Q>E		No	ClinGen gnomAD
TCGA novel	283	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768754246 CA399685052	284	T>A		No	ClinGen ExAC gnomAD
rs768754246 CA8585256	284	T>S		No	ClinGen ExAC gnomAD
CA8585255 rs748786575	285	I>V		No	ClinGen ExAC TOPMed gnomAD
CA399685039 rs1431101616	286	N>S		No	ClinGen gnomAD
rs1423960488 CA399685001	291	G>V		No	ClinGen gnomAD
rs775164058 CA8585254	292	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769533035 CA8585253	292	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745537306 CA8585251	295	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1262634394 CA399684967	297	P>L		No	ClinGen gnomAD
CA8585248 rs747398485	298	V>A		No	ClinGen ExAC
CA8585249 rs757626703	298	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1347225375 CA399684947	300	W>C		No	ClinGen gnomAD
rs1225553357 CA399684954	300	W>R		No	ClinGen gnomAD
CA8585247 rs778217364	302	E>K		No	ClinGen ExAC gnomAD
rs200971735 CA290800285	306	A>S		No	ClinGen Ensembl
CA399684888 rs1379188272	309	Q>E		No	ClinGen TOPMed gnomAD
CA290800283 rs765850038	310	T>A		No	ClinGen ExAC TOPMed gnomAD
rs765850038 CA8585244	310	T>S		No	ClinGen ExAC TOPMed gnomAD
rs755099766 CA8585243	314	L>H		No	ClinGen ExAC gnomAD
rs754080310 CA8585242	315	H>Y		No	ClinGen ExAC gnomAD
rs761641647 CA8585240	319	N>S		No	ClinGen ExAC gnomAD
rs979013935 CA290800278	322	G>C		No	ClinGen TOPMed
rs979013935 CA399684806	322	G>S		No	ClinGen TOPMed
CA8585239 rs774338036	323	L>P		No	ClinGen ExAC gnomAD
CA8585237 rs149225760	326	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs775076091 CA8585236	327	R>G		No	ClinGen ExAC gnomAD
rs1386124887 CA399684747	329	R>*		No	ClinGen TOPMed
rs368727081 CA399684744	329	R>L		No	ClinGen ESP TOPMed gnomAD
rs368727081 CA290800142	329	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs765154431 CA8585218	331	V>I		No	ClinGen ExAC gnomAD
CA399684706 rs1203948279	333	Y>H		No	ClinGen TOPMed gnomAD
rs1292147005 CA399684694 COSM187171	334	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs776049315 CA8585216	336	H>Y		No	ClinGen ExAC gnomAD
CA399684647 rs1386343478	337	S>*		No	ClinGen gnomAD
rs370094164 CA290800122	338	Y>C		No	ClinGen ESP TOPMed gnomAD
CA399684639 rs1165575809	338	Y>H		No	ClinGen gnomAD
CA399684574 rs1182860725	342	L>R		No	ClinGen gnomAD
rs770565020 CA8585214	343	T>S		No	ClinGen ExAC gnomAD
rs760348987 CA8585213	346	S>Y		No	ClinGen ExAC gnomAD
rs773495871 CA8585212	347	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1260814314 CA399683754 CA399683756	348	E>D		No	ClinGen TOPMed
TCGA novel	348	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767198200 CA8585189	350	P>L		No	ClinGen ExAC TOPMed gnomAD
rs767198200 CA399683734	350	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA290799662 rs895117982	351	L>F		No	ClinGen TOPMed
rs774605520 CA8585187	352	Y>H		No	ClinGen ExAC gnomAD
rs1448269249 CA399683694	353	C>G		No	ClinGen gnomAD
CA399683690 rs1448269249	353	C>S		No	ClinGen gnomAD
rs769170083 CA8585186	353	C>Y		No	ClinGen ExAC gnomAD
CA399683663 rs1323799718	355	G>R		No	ClinGen gnomAD
rs1265390509 CA399683646	356	G>V		No	ClinGen gnomAD
rs1395644174	357	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775584638 CA8585185	357	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1567667349 CA399683604	359	F>I		No	ClinGen Ensembl
rs746008150 CA8585182	361	W>R		No	ClinGen ExAC gnomAD
CA399683532 rs1467039052	362	D>G		No	ClinGen TOPMed
CA8585181 rs781530087	363	N>S		No	ClinGen ExAC gnomAD
CA399683471 rs1360973249	366	D>N		No	ClinGen gnomAD
CA290799659 rs928458876	367	H>R		No	ClinGen Ensembl
rs747903095 CA8585179	367	H>Y		No	ClinGen ExAC gnomAD
rs1463833173 CA399683415	369	M>V		No	ClinGen TOPMed gnomAD
rs753731447 CA8585176	375	C>R		No	ClinGen ExAC gnomAD
CA399683291 rs1182368769	382	E>G		No	ClinGen gnomAD
COSM979665 rs1302854122 CA399683258	387	E>K	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA399683242 rs1312667287	389	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8585173 rs749985548	389	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	394	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399683171 rs1291645410	397	D>G		No	ClinGen gnomAD
CA399683161 rs1223843231	398	V>G		No	ClinGen gnomAD
CA399683166 rs1353698657	398	V>M		No	ClinGen TOPMed
rs749899706 CA8585155	400	K>R		No	ClinGen ExAC gnomAD
rs767022425 CA8585154	403	I>S		No	ClinGen ExAC gnomAD
VAR_005236	403	I>T		No	UniProt
TCGA novel	405	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1343597390 CA399683095	406	T>I		No	ClinGen gnomAD
rs756848360 CA8585153	408	G>R		No	ClinGen ExAC gnomAD
CA8585152 rs751161673	409	S>R		No	ClinGen ExAC TOPMed gnomAD
CA399683068 rs1399770118	411	G>D		No	ClinGen gnomAD
rs763193803 CA8585150	411	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA290799501 rs1033966096	413	Y>C		No	ClinGen Ensembl
rs375451969 CA8585149	415	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1200853286 CA399683023	418	Q>P		No	ClinGen gnomAD
rs765786652 CA8585147	425	W>C		No	ClinGen ExAC gnomAD
CA399682969 rs1452768169	425	W>S		No	ClinGen TOPMed
CA399682950 rs1215084407	428	A>T		No	ClinGen gnomAD
CA8585145 rs776784418	431	F>V		No	ClinGen ExAC gnomAD
CA399682880 rs1193725459	432	M>I		No	ClinGen TOPMed
TCGA novel	433	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399682834 rs1437821982	435	N>K		No	ClinGen TOPMed
rs1405551165 CA399682842	435	N>T		No	ClinGen gnomAD
rs557426928 CA8585142	436	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA399682738 rs1429368570	441	A>G		No	ClinGen gnomAD
rs1364111667 CA399682729	442	W>*		No	ClinGen TOPMed
TCGA novel	446	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8585140 rs748988593	446	Q>K		No	ClinGen ExAC gnomAD
TCGA novel	447	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779856839 CA8585139	449	N>S		No	ClinGen ExAC gnomAD
CA8585138 rs769656999	450	K>T		No	ClinGen ExAC TOPMed gnomAD
CA399682590 rs1429110551	451	K>L		No	ClinGen gnomAD

No associated diseases with Q14457

3 regional properties for Q14457

Type	Name	Position	InterPro Accession
domain	Beclin-1, BH3 domain	105 - 129	IPR029318
domain	Atg6, BARA domain	264 - 445	IPR040455
domain	Atg6/beclin, coiled-coil domain	135 - 261	IPR041691

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein Endosome membrane ; Peripheral membrane protein Endoplasmic reticulum membrane ; Peripheral membrane protein Mitochondrion membrane ; Peripheral membrane protein Endosome Cytoplasmic vesicle, autophagosome	Interaction with ATG14 promotes translocation to autophagosomes Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

17 GO annotations of cellular component

Name	Definition
autophagosome	A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
endosome membrane	The lipid bilayer surrounding an endosome.
extrinsic component of membrane	The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
mitochondrial membrane	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
phagocytic vesicle	A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
phagophore assembly site	Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
phosphatidylinositol 3-kinase complex, class III	A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI).
phosphatidylinositol 3-kinase complex, class III, type I	A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p.
phosphatidylinositol 3-kinase complex, class III, type II	A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

5 GO annotations of molecular function

Name	Definition
GTPase binding	Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
identical protein binding	Binding to an identical protein or proteins.
phosphatidylinositol 3-kinase binding	Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

51 GO annotations of biological process

Name	Definition
aging	A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
amyloid-beta metabolic process	The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
autophagosome assembly	The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
autophagosome maturation	Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
autophagy of mitochondrion	The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cellular defense response	A defense response that is mediated by cells.
cellular response to aluminum ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.
cellular response to amino acid starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
cellular response to copper ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
cellular response to epidermal growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
cellular response to glucose starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
cellular response to hydrogen peroxide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
cellular response to nitrogen starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen.
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
early endosome to late endosome transport	The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
engulfment of apoptotic cell	The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
late endosome to vacuole transport	The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.
lysosome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
macroautophagy	The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
mitophagy	The selective autophagy process in which a mitochondrion is degraded by macroautophagy.
mitotic metaphase plate congression	The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of autophagosome assembly	Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.
negative regulation of cell death	Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of lysosome organization	Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization.
negative regulation of reactive oxygen species metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
neuron development	The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
phosphatidylinositol-3-phosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.
positive regulation of attachment of mitotic spindle microtubules to kinetochore	Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation.
positive regulation of autophagosome assembly	Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.
positive regulation of autophagy	Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of cardiac muscle hypertrophy	Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
positive regulation of intrinsic apoptotic signaling pathway	Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
positive regulation of phosphatidylinositol 3-kinase signaling	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
protein targeting to lysosome	The process of directing proteins towards the lysosome using signals contained within the protein.
receptor catabolic process	The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
regulation of autophagy	Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
regulation of catalytic activity	Any process that modulates the activity of an enzyme.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of macroautophagy	Any process that modulates the frequency, rate or extent of macroautophagy.
response to hypoxia	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to iron(II) ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus.
response to lead ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
response to mitochondrial depolarisation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria.
response to vitamin E	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4A1L4	BECN1	Beclin-1	Bos taurus (Bovine)	PR
Q5ZKS6	BECN1	Beclin-1	Gallus gallus (Chicken)	PR
A8MW95	BECN2	Beclin-2	Homo sapiens (Human)	PR
O88597	Becn1	Beclin-1	Mus musculus (Mouse)	PR
Q4A1L5	BECN1	Beclin-1	Sus scrofa (Pig)	PR
Q91XJ1	Becn1	Beclin-1	Rattus norvegicus (Rat)	PR
Q4A1L3	becn1	Beclin-1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MEGSKTSNNS	TMQVSFVCQR	CSQPLKLDTS	FKILDRVTIQ	ELTAPLLTTA	QAKPGETQEE
70	80	90	100	110	120
ETNSGEEPFI	ETPRQDGVSR	RFIPPARMMS	TESANSFTLI	GEASDGGTME	NLSRRLKVTG
130	140	150	160	170	180
DLFDIMSGQT	DVDHPLCEEC	TDTLLDQLDT	QLNVTENECQ	NYKRCLEILE	QMNEDDSEQL
190	200	210	220	230	240
QMELKELALE	EERLIQELED	VEKNRKIVAE	NLEKVQAEAE	RLDQEEAQYQ	REYSEFKRQQ
250	260	270	280	290	300
LELDDELKSV	ENQMRYAQTQ	LDKLKKTNVF	NATFHIWHSG	QFGTINNFRL	GRLPSVPVEW
310	320	330	340	350	360
NEINAAWGQT	VLLLHALANK	MGLKFQRYRL	VPYGNHSYLE	SLTDKSKELP	LYCSGGLRFF
370	380	390	400	410	420
WDNKFDHAMV	AFLDCVQQFK	EEVEKGETRF	CLPYRMDVEK	GKIEDTGGSG	GSYSIKTQFN
430	440
SEEQWTKALK	FMLTNLKWGL	AWVSSQFYNK