Q3ZBK2

PR
Gene name
PRXL2A (FAM213A, PAMM)
Protein name
Peroxiredoxin-like 2A
Names
Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes, Protein PAMM, Redox-regulatory protein FAM213A
Species
Bos taurus (Bovine)
KEGG Pathway
bta:534049
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

167-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3ZBK2

Entry ID Method Resolution Chain Position Source
AF-Q3ZBK2-F1 Predicted AlphaFoldDB

23 variants for Q3ZBK2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs209608567 11 I>V No EVA
rs454699827 36 E>G No EVA
rs440233884 41 I>T No EVA
rs458689835 44 K>T No EVA
rs470367159 45 T>I No EVA
rs110300397 57 A>V No EVA
rs455797103 61 K>R No EVA
rs134830652 79 E>G No EVA
rs438651588 95 G>S No EVA
rs799285801 96 V>A No EVA
rs136591424 96 V>I No EVA
rs481827374 100 A>S No EVA
rs448859182 115 P>L No EVA
rs467237162 117 F>L No EVA
rs479291938 123 L>V No EVA
rs456159870 160 S>C No EVA
rs443994566 160 S>T No EVA
rs441768647 170 L>R No EVA
rs460710365 173 V>A No EVA
rs722921155 174 F>L No EVA
rs479223729 175 V>M No EVA
rs479355427 184 L>R No EVA
rs447026167 187 H>D No EVA

No associated diseases with Q3ZBK2

No regional properties for Q3ZBK2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3ZBK2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Secreted
  • Secreted from mature adipocytes but not from preadipocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.

1 GO annotations of biological process

Name Definition
regulation of osteoclast differentiation Any process that modulates the frequency, rate or extent of osteoclast differentiation.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q58CY6 PRXL2B Prostamide/prostaglandin F synthase Bos taurus (Bovine) PR
Q9CYH2 Prxl2a Peroxiredoxin-like 2A Mus musculus (Mouse) PR
Q6AXX6 Prxl2a Peroxiredoxin-like 2A Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGMWSIGAGA IGVAALALLL ANTDMFLAKP EKAALEYLED IDLKTLEKDA VTFKAKALWE
70 80 90 100 110 120
KNGAVIMAVR RPGCFLCREE ATDLSSLKPK LDELGVPLYA VVKEHIKNEV KDFQPYFKGE
130 140 150 160 170 180
IFLDENKKFY GPQRRKMMFM GFVRLGVWQN FFRAWNGGFS GNLDGEGFIL GGVFVMGPGK
190 200 210
QGILLEHREK EFGDKVNLTS VLEAARKIRP QTSASEKQ