Q9CYH2

PR
Gene name
Prxl2a
Protein name
Peroxiredoxin-like 2A
Names
Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes, Protein PAMM, Redox-regulatory protein FAM213A
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:70564
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CYH2

Entry ID Method Resolution Chain Position Source
AF-Q9CYH2-F1 Predicted AlphaFoldDB

13 variants for Q9CYH2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs45761022 31 R>G No EVA
rs3389311882 45 T>I No EVA
rs3389332344 69 V>L No EVA
rs3404998968 117 F>* No EVA
rs3389335933 117 F>L No EVA
rs3404768350 123 L>Q No EVA
rs3389302762 149 Y>* No EVA
rs3389316453 152 F>I No EVA
rs3389335926 167 G>C No EVA
rs3403547790 204 A>S No EVA
rs51392512 210 L>P No EVA
rs3404998989 212 T>P No EVA
rs264822225 214 A>S No EVA

No associated diseases with Q9CYH2

No regional properties for Q9CYH2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9CYH2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Secreted
  • Secreted from mature adipocytes but not from preadipocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.

1 GO annotations of biological process

Name Definition
regulation of osteoclast differentiation Any process that modulates the frequency, rate or extent of osteoclast differentiation.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3ZBK2 PRXL2A Peroxiredoxin-like 2A Bos taurus (Bovine) PR
Q6AXX6 Prxl2a Peroxiredoxin-like 2A Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGMWSIGVGA VGAAAVALLL ANTDMFLSKP RKAALEYLED IDLKTLEKEP RTFKAKELWE
70 80 90 100 110 120
KNGAVIMAVR RPGCFLCRAE AADLMSLKPK LDELGVPLYA VVKEQVKREV EDFQPYFKGE
130 140 150 160 170 180
IFLDEKKKFY GPERRKMMFM GLIRLGVWYN SFRAWNGGFS GNLEGEGFIL GGVFVIGSGK
190 200 210
QGILLEHREK EFGDRVNPLS VLEAVKKIKL QTPASGRS