Q6AXX6

PR
Gene name
Prxl2a
Protein name
Peroxiredoxin-like 2A
Names
Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes, Protein PAMM, Redox-regulatory protein FAM213A, Sperm head protein 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:361118
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

176-229 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AXX6

Entry ID Method Resolution Chain Position Source
AF-Q6AXX6-F1 Predicted AlphaFoldDB

No variants for Q6AXX6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6AXX6

No associated diseases with Q6AXX6

No regional properties for Q6AXX6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6AXX6

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Secreted
  • Secreted from mature adipocytes but not from preadipocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.

1 GO annotations of biological process

Name Definition
regulation of osteoclast differentiation Any process that modulates the frequency, rate or extent of osteoclast differentiation.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3ZBK2 PRXL2A Peroxiredoxin-like 2A Bos taurus (Bovine) PR
Q9CYH2 Prxl2a Peroxiredoxin-like 2A Mus musculus (Mouse) PR
10 20 30 40 50 60
MSFLQDSSFF SMGMWSIGVG AFGAAALALL LANTDMFLSK PQKAALEYLE DIDLKTLEKE
70 80 90 100 110 120
PRTFKAKELW EKNGAVIMAV RRPGCFLCRA EAADLMSLKP KLDELGVPLY AVVKEKVKRE
130 140 150 160 170 180
VEDFQPYFKG EIFLDEKKKF YGPERRKMML MGLVRLGVWY NSFRAWKGGF SGNFEGEGFI
190 200 210 220
LGGVFVIGSG KQGVLLEHRE KEFGDRVNLL SVLEAVKKIK PQTPASRQS