AiPD: Autoinhibited Protein Database

Gene name	Aifm3 (Aifl)
Protein name	Apoptosis-inducing factor 3
Names	Apoptosis-inducing factor-like protein
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:72168
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-95 (Predicted disordered autoinhibitory region) PR

1-95 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3TY86-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389418737	9	K>N	No	EVA
rs3389365289	46	A>S	No	EVA
rs3389401178	108	K>E	No	EVA
rs3389396310	118	K>*	No	EVA
rs3389413267	119	G>C	No	EVA
rs3389404494	203	G>D	No	EVA
rs3389404561	243	D>E	No	EVA
rs3389407298	253	P>L	No	EVA
rs3389400790	300	S>T	No	EVA
rs3389398547	324	N>D	No	EVA
rs3389395035	337	V>I	No	EVA
rs3389396328	342	F>Y	No	EVA
rs3389404558	375	R>C	No	EVA
rs3389384410	392	Y>N	No	EVA
rs3406552316	407	L>P	No	EVA
rs3406381964	409	E>D	No	EVA
rs3406131409	411	V>G	No	EVA
rs3389398514	415	S>N	No	EVA
rs3389407330	434	G>S	No	EVA
rs3389396311	454	M>I	No	EVA
rs32326670	480	K>R	No	EVA
rs3389400838	527	Y>F	No	EVA
rs3389413236	552	S>C	No	EVA
rs3389384406	557	A>V	No	EVA
rs3389420729	565	P>H	No	EVA
rs3389365224	570	V>L	No	EVA
rs3389409569	579	A>D	No	EVA

Type	Name	Position	InterPro Accession
domain	Rieske [2Fe-2S] iron-sulphur domain	70 - 165	IPR017941
domain	FAD/NAD(P)-binding domain	196 - 493	IPR023753
domain	Reductase, C-terminal	512 - 583	IPR028202

		Description
EC Number
Subcellular Localization	Mitochondrion	Does not translocate to the nucleus upon induction of apoptosis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
2 iron, 2 sulfur cluster binding	Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
metal ion binding	Binding to a metal ion.
oxidoreductase activity, acting on NAD(P)H	Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

Name	Definition
execution phase of apoptosis	A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O95831	AIFM1	Apoptosis-inducing factor 1, mitochondrial	Homo sapiens (Human)	PR
Q96NN9	AIFM3	Apoptosis-inducing factor 3	Homo sapiens (Human)	PR
Q9Z0X1	Aifm1	Apoptosis-inducing factor 1, mitochondrial	Mus musculus (Mouse)	PR
Q9JM53	Aifm1	Apoptosis-inducing factor 1, mitochondrial	Rattus norvegicus (Rat)	PR
Q93WJ8	MDAR2	Monodehydroascorbate reductase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SR59	MDAR3	Monodehydroascorbate reductase 3	Arabidopsis thaliana (Mouse-ear cress)	PR