Q3T0J3

PR
Gene name
MRPL16
Protein name
39S ribosomal protein L16, mitochondrial
Names
L16mt, MRP-L16
Species
Bos taurus (Bovine)
KEGG Pathway
bta:538054
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q3T0J3

Entry ID Method Resolution Chain Position Source
2FTC EM - I 71-188 PDB
AF-Q3T0J3-F1 Predicted AlphaFoldDB

23 variants for Q3T0J3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs449810399 19 D>V No EVA
rs477753049 20 S>P No EVA
rs457756617 21 W>L No EVA
rs445528445 22 A>P No EVA
rs480158086 22 A>V No EVA
rs460081329 23 A>S No EVA
rs443714363 28 A>S No EVA
rs471573175 30 L>M No EVA
rs451579678 32 T>P No EVA
rs441194504 34 L>H No EVA
rs455659043 36 V>G No EVA
rs470003988 39 F>L No EVA
rs207623720 86 N>S No EVA
rs446888162 104 M>K No EVA
rs479761790 136 M>I No EVA
rs477276657 137 G>R No EVA
rs449276675 192 R>H No EVA
rs523472172 198 I>M No EVA
rs481282414 233 Y>* No EVA
rs464084100 233 Y>D No EVA
rs444117788 235 L>R No EVA
rs475169784 236 T>N No EVA
rs1117588090 250 R>H No EVA

No associated diseases with Q3T0J3

1 regional properties for Q3T0J3

Type Name Position InterPro Accession
domain Ribosomal protein L10e/L16 61 - 190 IPR016180

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).

2 GO annotations of molecular function

Name Definition
rRNA binding Binding to a ribosomal RNA.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38064 MRPL16 54S ribosomal protein L16, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A7MB75 TMEM231 Transmembrane protein 231 Bos taurus (Bovine) PR
Q9H6L2 TMEM231 Transmembrane protein 231 Homo sapiens (Human) PR
Q5M818 Mrpl16 39S ribosomal protein L16, mitochondrial Rattus norvegicus (Rat) PR
Q95747 RPL16 60S ribosomal protein L16, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRLLSGARA PVLRATLSDS WAAPPARAGL KTLLPVPTFE DVSIPEKPKL RFVERAPLVP
70 80 90 100 110 120
KVRREPKNLR DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG HFEMMRLTIN RFMDPKNMFA
130 140 150 160 170 180
LWRVPAPFKA ITRKGMGQRM GGGKGAIDHY VTPVKAGRLI VEVGGRCEFQ EVQGILNQVA
190 200 210 220 230 240
HKLPFPAKAV SRETLEKIQK DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHRGR
250
YWGKFYMPER V