P38064

PR
Gene name
MRPL16 (RML16, YBL038W, YBL0411)
Protein name
54S ribosomal protein L16, mitochondrial
Names
Mitochondrial large ribosomal subunit protein uL16m, YmL47
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBL038W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P38064

Entry ID Method Resolution Chain Position Source
3J6B EM 320 A K 1-232 PDB
5MRC EM 325 A K 38-232 PDB
5MRE EM 375 A K 38-232 PDB
5MRF EM 497 A K 38-232 PDB
AF-P38064-F1 Predicted AlphaFoldDB

3 variants for P38064

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-146220 11 S>A No SGRP
s02-146251 21 E>G No SGRP
s02-146841 218 I>F No SGRP

No associated diseases with P38064

2 regional properties for P38064

Type Name Position InterPro Accession
domain Ribosomal protein L10e/L16 48 - 179 IPR016180
conserved_site Ribosomal protein L16, conserved site 127 - 138 IPR020798

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
rRNA binding Binding to a ribosomal RNA.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T0J3 MRPL16 39S ribosomal protein L16, mitochondrial Bos taurus (Bovine) PR
Q5M818 Mrpl16 39S ribosomal protein L16, mitochondrial Rattus norvegicus (Rat) PR
Q95747 RPL16 60S ribosomal protein L16, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MFPYLTRMNL SIKMGGLTLK ESSPNAFLNN TTIARRFKHE YAPRFKIVQK KQKGRVPVRT
70 80 90 100 110 120
GGSIKGSTLQ FGKYGLRLKS EGIRISAQQL KEADNAIMRY VRPLNNGHLW RRLCTNVAVC
130 140 150 160 170 180
IKGNETRMGK GKGGFDHWMV RVPTGKILFE INGDDLHEKV AREAFRKAGT KLPGVYEFVS
190 200 210 220 230
LDSLVRVGLH SFKNPKDDPV KNFYDENAKK PSKKYLNILK SQEPQYKLFR GR