Q3SZI0
Gene name |
MPI |
Protein name |
Mannose-6-phosphate isomerase |
Names |
Phosphohexomutase, Phosphomannose isomerase, PMI |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:513586 |
EC number |
5.3.1.8: Interconverting aldoses and ketoses |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SZI0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SZI0-F1 | Predicted | AlphaFoldDB |
71 variants for Q3SZI0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs458120928 | 4 | Q>H | No | EVA | |
| rs470175402 | 6 | V>A | No | EVA | |
| rs470175402 | 6 | V>G | No | EVA | |
| rs450465142 | 7 | F>L | No | EVA | |
| rs447889171 | 18 | W>L | No | EVA | |
| rs479227044 | 21 | M>R | No | EVA | |
| rs458615756 | 23 | S>A | No | EVA | |
| rs444908712 | 33 | S>R | No | EVA | |
| rs482736100 | 34 | S>R | No | EVA | |
| rs462376993 | 34 | S>R | No | EVA | |
| rs442338110 | 35 | D>N | No | EVA | |
| rs473907505 | 35 | D>V | No | EVA | |
| rs440179014 | 41 | S>P | No | EVA | |
| rs471590172 | 43 | D>G | No | EVA | |
| rs452547328 | 46 | Y>N | No | EVA | |
| rs209212129 | 144 | P>A | No | EVA | |
| rs442159158 | 164 | V>G | No | EVA | |
| rs473100151 | 166 | E>A | No | EVA | |
| rs470579387 | 167 | F>L | No | EVA | |
| rs439259587 | 167 | F>V | No | EVA | |
| rs457270138 | 168 | Q>E | No | EVA | |
| rs437104281 | 171 | I>V | No | EVA | |
| rs474879904 | 174 | N>T | No | EVA | |
| rs454668652 | 186 | D>G | No | EVA | |
| rs446875799 | 198 | F>C | No | EVA | |
| rs433192398 | 208 | V>G | No | EVA | |
| rs464379554 | 209 | V>G | No | EVA | |
| rs450756495 | 217 | V>L | No | EVA | |
| rs462420836 | 220 | I>L | No | EVA | |
| rs207611942 | 221 | S>L | No | EVA | |
| rs448598941 | 221 | S>P | No | EVA | |
| rs440634641 | 224 | V>L | No | EVA | |
| rs211344964 | 267 | A>V | No | EVA | |
| rs472643256 | 286 | C>G | No | EVA | |
| rs444790464 | 299 | T>K | No | EVA | |
| rs458931748 | 315 | T>P | No | EVA | |
| rs438793352 | 317 | S>R | No | EVA | |
| rs476912218 | 319 | S>N | No | EVA | |
| rs456760050 | 322 | R>G | No | EVA | |
| rs436616868 | 323 | L>P | No | EVA | |
| rs518936371 | 328 | R>Q | No | EVA | |
| rs474405449 | 329 | S>G | No | EVA | |
| rs453832419 | 329 | S>R | No | EVA | |
| rs433655180 | 330 | P>S | No | EVA | |
| rs432721801 | 332 | D>A | No | EVA | |
| rs444816641 | 335 | L>R | No | EVA | |
| rs437541827 | 337 | I>M | No | EVA | |
| rs469333120 | 339 | D>H | No | EVA | |
| rs480492646 | 344 | D>G | No | EVA | |
| rs460315212 | 345 | F>V | No | EVA | |
| rs475520269 | 352 | V>I | No | EVA | |
| rs461839507 | 353 | P>H | No | EVA | |
| rs441618350 | 354 | G>A | No | EVA | |
| rs472987104 | 356 | V>G | No | EVA | |
| rs453266476 | 357 | T>S | No | EVA | |
| rs470836598 | 359 | Y>F | No | EVA | |
| rs436974408 | 360 | K>Q | No | EVA | |
| rs469487199 | 361 | V>F | No | EVA | |
| rs449366456 | 365 | D>A | No | EVA | |
| rs435624011 | 368 | S>I | No | EVA | |
| rs466815624 | 373 | V>E | No | EVA | |
| rs446755417 | 374 | Q>R | No | EVA | |
| rs478335430 | 376 | T>K | No | EVA | |
| rs458240556 | 377 | V>G | No | EVA | |
| rs451025948 | 378 | T>P | No | EVA | |
| rs482448538 | 384 | A>P | No | EVA | |
| rs461864958 | 403 | S>R | No | EVA | |
| rs473050455 | 413 | D>A | No | EVA | |
| rs41980321 | 413 | D>N | No | EVA | |
| rs459343450 | 420 | C>S | No | EVA | |
| rs482328400 | 421 | C>Y | No | EVA |
No associated diseases with Q3SZI0
Functions
| Description | ||
|---|---|---|
| EC Number | 5.3.1.8 | Interconverting aldoses and ketoses |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mannose-6-phosphate isomerase activity | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| GDP-mannose biosynthetic process | The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. |
| mannose to fructose-6-phosphate metabolic process | The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P29952 | PMI40 | Mannose-6-phosphate isomerase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A5A6K3 | MPI | Mannose-6-phosphate isomerase | Pan troglodytes (Chimpanzee) | PR |
| P34949 | MPI | Mannose-6-phosphate isomerase | Homo sapiens (Human) | PR |
| Q9M884 | PMI1 | Mannose-6-phosphate isomerase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAQRVFPLS | CVVQQYAWGK | MGSNSEVARL | LASSDPLAQI | SEDRPYAELW | MGTHPRGDAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILDNRISQKT | LGQWIADNQD | SLGSKVKDTF | NGKLPFLFKV | LSVETALSIQ | AHPNKELAEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHLQAPQHYP | DANHKPEMAI | ALTPFQGLCG | FRPVEEIVTF | LTKVPEFQFL | IGDNAAAQLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSLSQDSEAV | TSALRSCFSH | LMKSEKKVVV | EQLNLLVKRI | SQQVAAGNNM | EDICGELLLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LHQQYPGDIG | CFAIYFLNLL | TLKPGEAMFL | EANVPHAYLK | GDCVECMACS | DNTVRAGLTP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KFIDVPTLCE | MLSYTPSPSQ | DRLFPPARSP | EDPYLSIYDP | PVPDFTVMKV | EVPGSVTEYK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VLALDSASIL | LVVQGTVTAS | SPTAQAAIPL | KRGGVLFIGA | NESVSLKLTV | PKDLLMFRAC |
| CLL |