P29952
Gene name |
PMI40 (YER003C) |
Protein name |
Mannose-6-phosphate isomerase |
Names |
Phosphohexomutase, Phosphomannose isomerase, PMI |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YER003C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P29952
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P29952-F1 | Predicted | AlphaFoldDB |
3 variants for P29952
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s05-158930 | 32 | H>L | No | SGRP | |
| s05-158385 | 214 | K>E | No | SGRP | |
| s05-157998 | 343 | S>A | No | SGRP |
No associated diseases with P29952
5 regional properties for P29952
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Phosphomannose isomerase, type I, conserved site | 128 - 136 | IPR018050-1 |
| conserved_site | Phosphomannose isomerase, type I, conserved site | 281 - 306 | IPR018050-2 |
| domain | Phosphomannose isomerase type I, C-terminal domain | 343 - 392 | IPR046456 |
| domain | Phosphomannose isomerase type I, catalytic domain | 5 - 153 | IPR046457 |
| domain | Phosphomannose isomerase type I, helical insertion domain | 169 - 262 | IPR046458 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mannose-6-phosphate isomerase activity | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| cell wall mannoprotein biosynthetic process | The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. |
| GDP-mannose biosynthetic process | The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZI0 | MPI | Mannose-6-phosphate isomerase | Bos taurus (Bovine) | PR |
| A5A6K3 | MPI | Mannose-6-phosphate isomerase | Pan troglodytes (Chimpanzee) | PR |
| P34949 | MPI | Mannose-6-phosphate isomerase | Homo sapiens (Human) | PR |
| Q9M884 | PMI1 | Mannose-6-phosphate isomerase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNKLFRLDA | GYQQYDWGKI | GSSSAVAQFA | AHSDPSVQIE | QDKPYAELWM | GTHSKMPSYN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HESKESLRDI | ISKNPSAMLG | KDIIDKFHAT | NELPFLFKVL | SIEKVLSIQA | HPDKALGKIL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HAQDPKNYPD | DNHKPEMAIA | VTDFEGFCGF | KPLQEIADEL | KRIPELRNIV | GEETSRNFIE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NIQPSAQKGS | PEDEQNKKLL | QAVFSRVMNA | SDDKIKIQAR | SLVERSKNSP | SDFNKPDLPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LIQRLNKQFP | DDVGLFCGCL | LLNHCRLNAG | EAIFLRAKDP | HAYISGDIME | CMAASDNVVR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AGFTPKFKDV | KNLVSMLTYT | YDPVEKQKMQ | PLKFDRSSGN | GKSVLYNPPI | EEFAVLETTF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DEKLGQRHFE | GVDGPSILIT | TKGNGYIKAD | GQKLKAEPGF | VFFIAPHLPV | DLEAEDEAFT |
| TYRAFVEPN |