A5A6K3
Gene name |
MPI |
Protein name |
Mannose-6-phosphate isomerase |
Names |
Phosphohexomutase, Phosphomannose isomerase, PMI |
Species |
Pan troglodytes (Chimpanzee) |
KEGG Pathway |
ptr:453748 |
EC number |
5.3.1.8: Interconverting aldoses and ketoses |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5A6K3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5A6K3-F1 | Predicted | AlphaFoldDB |
No variants for A5A6K3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A5A6K3 | |||||
No associated diseases with A5A6K3
5 regional properties for A5A6K3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Phosphomannose isomerase, type I, conserved site | 129 - 137 | IPR018050-1 |
| conserved_site | Phosphomannose isomerase, type I, conserved site | 276 - 301 | IPR018050-2 |
| domain | Phosphomannose isomerase type I, C-terminal domain | 337 - 381 | IPR046456 |
| domain | Phosphomannose isomerase type I, catalytic domain | 6 - 154 | IPR046457 |
| domain | Phosphomannose isomerase type I, helical insertion domain | 170 - 257 | IPR046458 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.3.1.8 | Interconverting aldoses and ketoses |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mannose-6-phosphate isomerase activity | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| GDP-mannose biosynthetic process | The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P29952 | PMI40 | Mannose-6-phosphate isomerase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SZI0 | MPI | Mannose-6-phosphate isomerase | Bos taurus (Bovine) | PR |
| P34949 | MPI | Mannose-6-phosphate isomerase | Homo sapiens (Human) | PR |
| Q9M884 | PMI1 | Mannose-6-phosphate isomerase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPRVFPLS | CAVQQYAWGK | MGSNSEVARL | LASSDPLAQI | AEDKPYAELW | MGTHPRGDAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILDNRISQKT | LSQWIAENQD | SLGSKVKDTF | NGNLPFLFKV | LSVETPLSIQ | AHPNKELAEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LHLQAPQHYP | DANHKPEMAI | ALTPFQGLCG | FRPVEEIVTF | LKKVPEFQFL | IGDEAATHLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QTMSHDSQAV | ASSLQSCFSH | LMKSEKKVVV | EQLNLLVKRI | SQQAAAGNNM | EDIFGELLLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LHQQYPGDIG | CFAIYFLNLL | TLKPGEAMFL | EANVPHAYLK | GDCVECMACS | DNTVRAGLTP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KFIDVPTLCE | MLSYTPSSSK | DRLFLPTRSR | EDPYLSIYDP | PVPDFTIMKT | EVPGSVTGYK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VLALDSASIL | LMVQGTVIAS | TPTTQTPIPL | QRGGVLFIGA | NESVSLKLTE | PKDLLIFRAC |
| CLL |